个人简介
教育背景:
1993.09 - 1997.07,河北大学,微生物学,学士
1997.09 - 2000.07,四川大学,微生物遗传学,硕士
2000.09 - 2003.10,中国科学院微生物研究所,微生物遗传学,博士
工作经历:
2004.02 - 2008.02,美国威斯康辛大学麦迪逊分校药学院,博士后
2008.03 - 2009.08,美国 PPD 生物制药公司,研究员
2009.09 - 至今,中国海洋大学医药学院,教授
获奖荣誉:
2010 年,教育部新世纪优秀人才
2015 年,山东省研究生优秀科技创新成果省部二等奖(指导硕士研究生张永贺)
2016 年,山东省研究生优秀科技创新成果省部二等奖(指导博士研究生刘扬)
2017 年,第十七届优秀博士学位论文指导奖(中国海洋大学)
2018 年,第二十届 “天泰优秀人才奖” 一等奖(中国海洋大学)
研究领域
海洋药源分子生物合成机制及新颖酶催化机制研究
海洋药源分子的合成生物学研究
基于基因组挖掘的海洋微生物药源分子的定向发现
近期论文
查看导师新发文章
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1. Zhang Y.; Huang H.; Xu S.; Wang B.; Ju J.; Tan H.; Li W.* .
Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology.
Microb Cell Fact. 2015, DOI: 10.1186/s12934-015-0244-2.
2. Che Q.#; Li T.#; Liu X.; Yao T.; Li J.; Gu Q.; Li D.*, Li W.*; Zhu T*.
Genome scanning inspired isolation of reedsmycins A-F, polyene-polyol macrolides from Streptomyces sp. CHQ-64.
RSC Adv. 2015, 5, 22777-22782.
3. Ding X.; Chen C.; Cui Q.; Li W.*; Feng Y.
Resonance assignments of the periplasmic domain of a cellulose-sensing trans-membrane anti-sigma factor from Clostridium thermocellum.
Bimol NMR Assign. 2015, DOI: 10.1007/s12104-015-9601-7.
4. Song X.; Wang X.; Tan Y.; Feng Y.; Li W.; Cui Q.
High production of squalene using a newly isolated yeast-like strain Pseudozymasp. SD301.
J. Agric. Food Chem.2015,DOI: 10.1021/acs.jafc.5b03539.
5. Qin W.; Liu Y.; Ren P.; Zhang J.; Li H.; Tian L.;Li W*.
Uncovering a glycosyltransferase provides insights into the glycosylation step during macrolactins and bacillaenes biosynthesis.
ChemBioChem, 2014, 15(18), 2747-2753.
6. Liu Y.; Zheng H.; Qin W.; Zhan G.; Tian L; Li W*.
Establishment of an efficient transformation protocol and its application in marine-derived Bacillus strain.
Sci. China Life Sci. 2014, 57, 627-635.
7. Li T.; Du Y.; Cui Q.; Zhang J.; Zhu W.; Hong K.*; Li W*.
Cloning, characterization and heterologous expression of the indolocarbazole biosynthetic gene cluster from marine-derived Streptomyces sanyensisFMA.
Mar. Drugs 2013, 11, 466-488.
8. Gao M.; Song X.; Feng Y.; Li W.; Cui Q.
Isolation and characterization of Aurantiochytrium species: high docosahexaenoic acid (DHA) production by the newly isolated microalga,Aurantiochytriumsp. SD116.
J Oleo Sci. 2013, 62(3), 143-151.
9. Cui G.; Hong W.; Zhang J.; Li W.; Feng Y.; Liu C.; Cui Q.
Targeted gene engineering in Clostridium cellulolyticum H10 without methylation.
J. Microbiol. Methods. 2012, 89, 201-208.
10. Yang D.; Li W.; Huang S.; Shen B.
Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes.
Org. Lett. 2012, 14(5), 1302-1305.
11. Luo Y.; Li W.; Ju J.; Yuan Q.; Peter N.R.; Hoffmann F.M.; Huang S.; Bugni T.S.; Rajski S.; Osada H.; Shen B.
Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.
J. Am. Chem. Soc. 2010, 132, 6663-6671.