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个人简介

教育背景: 1993.09 - 1997.07,河北大学,微生物学,学士 1997.09 - 2000.07,四川大学,微生物遗传学,硕士 2000.09 - 2003.10,中国科学院微生物研究所,微生物遗传学,博士 工作经历: 2004.02 - 2008.02,美国威斯康辛大学麦迪逊分校药学院,博士后 2008.03 - 2009.08,美国 PPD 生物制药公司,研究员 2009.09 - 至今,中国海洋大学医药学院,教授 获奖荣誉: 2010 年,教育部新世纪优秀人才 2015 年,山东省研究生优秀科技创新成果省部二等奖(指导硕士研究生张永贺) 2016 年,山东省研究生优秀科技创新成果省部二等奖(指导博士研究生刘扬) 2017 年,第十七届优秀博士学位论文指导奖(中国海洋大学) 2018 年,第二十届 “天泰优秀人才奖” 一等奖(中国海洋大学)

研究领域

海洋药源分子生物合成机制及新颖酶催化机制研究 海洋药源分子的合成生物学研究 基于基因组挖掘的海洋微生物药源分子的定向发现

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Zhang Y.; Huang H.; Xu S.; Wang B.; Ju J.; Tan H.; Li W.* . Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology. Microb Cell Fact. 2015, DOI: 10.1186/s12934-015-0244-2. 2. Che Q.#; Li T.#; Liu X.; Yao T.; Li J.; Gu Q.; Li D.*, Li W.*; Zhu T*. Genome scanning inspired isolation of reedsmycins A-F, polyene-polyol macrolides from Streptomyces sp. CHQ-64. RSC Adv. 2015, 5, 22777-22782. 3. Ding X.; Chen C.; Cui Q.; Li W.*; Feng Y. Resonance assignments of the periplasmic domain of a cellulose-sensing trans-membrane anti-sigma factor from Clostridium thermocellum. Bimol NMR Assign. 2015, DOI: 10.1007/s12104-015-9601-7. 4. Song X.; Wang X.; Tan Y.; Feng Y.; Li W.; Cui Q. High production of squalene using a newly isolated yeast-like strain Pseudozymasp. SD301. J. Agric. Food Chem.2015,DOI: 10.1021/acs.jafc.5b03539. 5. Qin W.; Liu Y.; Ren P.; Zhang J.; Li H.; Tian L.;Li W*. Uncovering a glycosyltransferase provides insights into the glycosylation step during macrolactins and bacillaenes biosynthesis. ChemBioChem, 2014, 15(18), 2747-2753. 6. Liu Y.; Zheng H.; Qin W.; Zhan G.; Tian L; Li W*. Establishment of an efficient transformation protocol and its application in marine-derived Bacillus strain. Sci. China Life Sci. 2014, 57, 627-635. 7. Li T.; Du Y.; Cui Q.; Zhang J.; Zhu W.; Hong K.*; Li W*. Cloning, characterization and heterologous expression of the indolocarbazole biosynthetic gene cluster from marine-derived Streptomyces sanyensisFMA. Mar. Drugs 2013, 11, 466-488. 8. Gao M.; Song X.; Feng Y.; Li W.; Cui Q. Isolation and characterization of Aurantiochytrium species: high docosahexaenoic acid (DHA) production by the newly isolated microalga,Aurantiochytriumsp. SD116. J Oleo Sci. 2013, 62(3), 143-151. 9. Cui G.; Hong W.; Zhang J.; Li W.; Feng Y.; Liu C.; Cui Q. Targeted gene engineering in Clostridium cellulolyticum H10 without methylation. J. Microbiol. Methods. 2012, 89, 201-208. 10. Yang D.; Li W.; Huang S.; Shen B. Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes. Org. Lett. 2012, 14(5), 1302-1305. 11. Luo Y.; Li W.; Ju J.; Yuan Q.; Peter N.R.; Hoffmann F.M.; Huang S.; Bugni T.S.; Rajski S.; Osada H.; Shen B. Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. J. Am. Chem. Soc. 2010, 132, 6663-6671.

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