朱伟明 - 中国海洋大学

个人简介

教育背景： 1981.09 - 1985.07，武汉大学化学系（现化学与分子科学学院），金属有机化学，学士 1985.09 - 1988.07，武汉大学化学系（现化学与分子科学学院），金属有机化学，硕士 1997.03 - 2001.11，中国科学院研究生院（昆明植物研究所），天然产物化学，博士工作经历： 1988.07 - 2003.11，云南师范大学化学系（现化学化工学院），有机化学，助教、教师、副教授、教授 2001.11 - 2003.11，中国科学院上海有机化学研究所，有机合成化学，博士后 2003.12 - 至今，中国海洋大学医药学院，微生物药物化学，教授获奖荣誉： 1989 年云南省省级国家机关 “先进讲师团成员” 1993 年云南省首届高校青年教师课堂教学比赛省级一等奖 2006 年第九届中国药学会施维雅青年药物化学奖 2007 年中国海洋大学第九届 “天泰优秀人才奖” 一等奖 2010 年中国海洋大学第十二届 “天泰优秀人才奖” 一等奖 2014 年山东省优秀博士论文指导奖 2015 年 Marine Drugs Best Paper Award

研究领域

特境微生物来源的含氮与卤代化合物的发现与优化微生物来源药物先导物的成药性研究海洋微生物的化学共生关系研究

近期论文

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1. Jingjing Shen, Yaqin Fan, Guoliang Zhu, Hao Chen, Weiming Zhu,* Peng Fu.* Polycyclic macrolactams generated via intramolecular Diels–Alder reactions from an antarctic Streptomyces species. Org. Lett. 2019, online. doi.org/10.1021/acs.orglett.9b01710. 2. Yaqin Fan, Yi Wang, Peng Fu*, ArthitChairoungdua, PawineePiyachaturawat, Weiming Zhu*. Secopaxilline A, an indole-diterpenoid derivative from an aciduric Penicillium fungus, its identification and semisynthesis.Org. Chem. Front. 2018, 5(19): 2835–2839. 3. Yuqi Du, Jian Sun, Qianhong Gong, Yi Wang, Peng Fu,*Weiming Zhu*.New α‑pyridones with quorum-sensing inhibitory activity from diversity-enhanced extracts of a Streptomyces sp. derived from marine algae.J Agric Food Chem 2018, 66(8): 1807–1812. 4. Xia Li, Hongguang Ma, Lin Li, Yifan Chen, Xiao Sun, Zizheng Dong, Jing-Yuan Liu, WeimingZhu,* Jian-Ting Zhang.* Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth. Oncogene 2018, 37(18): 2469–2480. 5. Tonghan Zhu, Zhenyu Lu, Jie Fan, Liping Wang, Guoliang Zhu, Yi Wang, Xia Li, Kui Hong, PawineePiyachaturawat, ArthitChairoungdua, WeimingZhu.*Ophiobolins from the mangrove fungus Aspergillus ustus.J Nat Prod 2018, 81(1): 2–9. 6. Miaomiao Wang, Shuyao Wang, Wei Wang*, Yi Wang, Hui Wang, Weiming Zhu*. Inhibition effects of novel polyketide compound PPQ-B against influenza A virus replication by interfering with the cellular EGFR pathway. Antiviral Research2017, 143: 74–84. 7. Cong Wang, Lei Guo, Jiejie Hao, Liping Wang, Weiming Zhu*. α-Glucosidase inhibitors from the marine-derived fungus Aspergillus flavipes HN4-13.J Nat Prod2016, 79(11):2977-2981. 8. Zhengbo Chen, Jiejie Hao, Liping Wang, Yi Wang*, Fandong Kong, Weiming Zhu*. New α-glucosidase inhibitors from marine algae-derived Streptomycessp. OUCMDZ-3434.Sci Rep 2016, 6: 20004. 9. Liping Wang, Xiangui Mei, Cong Wang, Weiming Zhu*. Biomimetic semi-synthesis of fradcarbazole A and its analogues. Tetrahedron2015, 71(42): 7990–7997. 10. Peng Fu, Yiguang Zhu, Xiangui Mei, Yi Wang, Haijian Jia, Changsheng Zhang*, Weiming Zhu*. Acyclic congeners from Actinoalloteichuscyanogriseus provide insights into cyclic bipyridine glycoside formation. Org Lett 2014, 16(16): 4264–4267. 11. Peng Fu,Fandong Kong,Xia Li, Yi Wang,and Weiming Zhu*. Cyanogramide with a new spiro[indolinone-pyrroloimidazole] skeleton from Actinoalloteichuscyanogriseus. Org Lett2014, 16(14): 3708–3711. 12. Fandong Kong, Yi Wang, Peipei Liu, Tianhan Dong, and Weiming Zhu*, Thiodiketopiperazines from the marine-derived fungus Phoma sp. OUCMDZ-1847. J NatProd2014, 77 (1): 132–137. 13. Yiguang Zhu Qingbo Zhang, Sumei Li, Qinheng Lin, Peng Fu, Guangtao Zhang, Haibo Zhang, Rong Shi, Weiming Zhu*, and Changsheng Zhang*, Insights into caerulomycin a biosynthesis: a two-component monooxygenase Crmh-catalyzed oxime formation. J Am Chem Soc2013, 135(50), 18750–18753. 14. Liping Wang, Weiming Zhu*, Versicolactones A and B: total synthesis and structure revision. TetrahedronLett2013, 54(49), 6729–6731. 15. Yaqin Fan, Yi Wang, Peipei Liu, Peng Fu, Tonghan Zhu, Wei Wang, and Weiming Zhu*, Indole-diterpenoids with anti-H1N1 activity from the aciduric fungus Penicillium camembertiOUCMDZ-1492. J Nat Prod 2013, 76(7): 1328–1336. 16. Peng Fu, Yibin Zhuang, Yi Wang, Peipei Liu, Xin Qi, Kangbo Gu, Daojing Zhang,Weiming Zhu*, New indolocarbazoles from a mutant strain of the marine-derived actinomycete Streptomycesfradiae 007M135. Org Lett 2012, 14(24): 6194–6197. 17. Peng Fu, Chunli Yang, Yi Wang, Peipei Liu, Yiming Ma, Lei Xu, MingboSu, Kui Hong*, Weiming Zhu*, Streptocarbazoles A and B, two novel indolocarbazoles from the marine-derived actinomycete strain Streptomyces sp. FMA.Org Lett2012, 14(9): 2422–2425. 18. Peng Fu,Peipei Liu,Xia Li,Yi Wang,Shuxia Wang,Kui Hong,Weiming Zhu*, Cyclic bipyridine glycosides from the marine-derived actinomyceteActinoalloteichuscyanogriseus WH1-2216-6, Org Lett 2011, 13(22): 5948–5951. 19. Hui Wang,Yi Wang,Wei Wang, Peng Fu,Peipei Liu,Weiming Zhu*, Anti-influenza virus polyketides from the acid-tolerant fungus Penicillium purpurogenum JS03-21, J Nat Prod 2011, 74(9): 2014–2018. 21. Yibin Zhuang, Xiancun Teng, Yi Wang, Peipei Liu, Guoqiang Li, and Weiming Zhu*. New quinazolinone alkaloids within rare amino acid residue from coral-associated fungus, Aspergillus versicolor LCJ-5-4, Org Lett2011, 13(5): 1130–1133. 22. Jinkai Zheng, Zhihong Xu, Yi Wang, Kui Hong, Peipei Liu, and Weiming Zhu*, Cyclic tripeptides from the halotolerant fungus Aspergillus sclerotiorumPT06-1, J Nat Prod 2010, 73(6): 1133–1137. 23. Jinkai Zheng, Huajie Zhu,Kui Hong,Yi Wang,Peipei Liu,Xin Wang,Xiaoping Peng,Weiming Zhu*, Novel cyclic hexapeptides from marine-derived fungus, Aspergillus sclerotiorum PT06-1, Org Lett 2009, 11 (22): 5262–5265. 24. Hongwen Tao, Xiaojiang Hao, Jinggen Liu, Jian Ding, Yuchun Fang, Qianqun Gu and Weiming Zhu*, Resin glycoside constituents of Ipomoea pes-caprae (Beach Morning Glory), J Nat Prod 2008, 71 (12): 1998– 2003. 25. Lin Du, Tianjiao Zhu, Yuchun Fang, Qianqun Gu*, andWeiming Zhu*, Unusual C25 steroid isomers with bicyclo[4.4.1]A/B rings from a volcano ash-derived fungus Penicillium citrinum, J Nat Prod 2008, 71 (8): 1343–1351. 26. Zhi Hong Xin, Yuchun Fang, Lin Du, Tianjiao Zhu, Lin Duan, Juan Chen, Qian-QunGu,* and Wei-Ming Zhu*, Aurantiomides A-C, quinazoline alkaloids from the sponge-derived fungus Penicillium aurantiogriseumSP0-19, J Nat Prod 2007, 70 (5): 853–855. 27. Li Chen, Yuchun Fang,Xiaodong Luo,Hongping He,Tianjiao Zhu, Hongbing Liu, QianqunGu,*Weiming Zhu,*Sulfated alkenes from the echinus Temnopleurushardwickii,J Nat Prod 2006, 69 (12): 1787–1789. 28. Weizhong Liu, Qianqun Gu*, Weiming Zhu*, Chengbin Cui, Guotao Fan, Tianjiao Zhu, Hongbing Liu, Yuchun Fang, Penicillones A and B, two novel polyketides with tricyclo [5.3.1.03,8] undecane skeleton, from a marine-derived fungus Penicilliumterrestre. Tetrahedron Lett2005, 46 (30): 4993–4996.