个人简介
Weibo Cai received his BS degree from Nanjing University in 1995 and a PhD degree in Chemistry from the University of California at San Diego in 2004. After three years of post-doctoral training at the Molecular Imaging Program at Stanford University, he joined the University of Wisconsin - Madison as a Biomedical Engineering Cluster Hire in February 2008. Dr. Cai is currently a Vilas Distinguished Achievement Professor with joint appointment in the Departments of Radiology and Medical Physics, as well as affiliation with Biomedical Engineering, Materials Science & Engineering, and Pharmaceutical Sciences.
Prof. Cai is currently a member of the UW Carbone Cancer Center (UWCCC), UW Stem Cell & Regenerative Medicine Center (UW-SCRMC), UW Cardiovascular Research Center (UW-CVRC), and the UW Institute for Clinical and Translational Research (UW-ICTR). In addition, Professor Cai is a trainer of several training programs at UW including the Biotechnology Training Program, Materials Science Program, Radiological Sciences Training Program, Graduate Program in Cellular and Molecular Biology, and the Chemistry-Biology Interface Training Program.
Prof. Cai has authored > 270 peer-reviewed articles, > 20 book chapters, > 280 conference abstracts, edited 3 books, given > 240 talks,and guest-edited many special topic issues for various peer-reviewed journals. His work has been cited > 18,000 times (H-index: 70). Prof. Cai has served on the Editorial Board of > 20 scientific journals (e.g. Theranostics, Journal of Nuclear Medicine, European Journal of Nuclear Medicine and Molecular Imaging, Molecular Pharmaceutics, Scientific Reports, American Journal of Cancer Research, American Journal of Translational Research, etc.), performed peer-review for > 100 journals, participated in many grant review panels, chaired many sessions of international conferences, among others. He is teaching a 3-credit class entitled “Multimodality Molecular Imaging in Living Subjects” which is offered in the spring semester every other year. Prof. Cai is currently the Editor-in-Chief of the American Journal of Nuclear Medicine and Molecular Imaging (AJNMMI).
Honors and Awards
Inaugural Nano Research Young Innovators (NR45) in Nanobiotechnology (2018)
Fellow, American Institute for Medical and Biological Engineering (AIMBE) (2018)
Nano-Micro Letters (NML) Researcher Award (2018)
Vilas Distinguished Achievement Professorship Award, UW - Madison (2016-2021)
Plenary Lecturer, European Association of Nuclear Medicine (EANM) Annual Congress (2016)
Vilas Associate Award, UW - Madison Graduate School (2014-2016)
1st Annual Society of Nuclear Medicine and Molecular Imaging (SNMMI), Future Leaders Academy (2014)
Siemens Novel Application Image of the Year (2nd Place) (2013)
South Central Wisconsin Affiliate of Susan G. Komen SMART Komen Champions (2013)
EANM Springer Prize for Best Basic Science Paper (2013)
Department of Defense Prostate Cancer Research Highlights (2013)
American Cancer Society Research Scholar (2013-2017)
Berson-Yalow Award, Society of Nuclear Medicine (as Senior Author) (2012)
EANM Eckert & Ziegler Abstract Award (2012)
Rusch Poster Award for Best Basic Research, UWCCC Annual Research Retreat (2012)
EANM Springer Prize for Most Cited Paper (2011)
Press Release, Society of Nuclear Medicine Annual Meeting (2011)
Department of Defense Prostate Cancer Research Program IDEA Award (2011-2014)
Wisconsin Partnership Program MERC New Investigator Award (2009-2012)
Top 10 Molecular Imaging Research Papers from Journal of Nuclear Medicine (2007)
SNM Young Professionals Committee Best Basic Science Award (1st Place) (2007)
Society of Nuclear Medicine Benedict Cassen Post-Doctoral Fellowship (2006-2008)
Top 10 Most-Cited Articles in Nano Letters (2006)
Stanford University School of Medicine Dean’s Fellowship (2005-2006)
Model Teaching Assistant, Department of Chemistry & Biochemistry, UCSD (2003)
研究领域
The research projects in our laboratory are focused on molecular imaging, molecular therapy, and nanotechnology. Molecular medicine is the future of 21st century patient management. Molecular imaging, “the visualization, characterization and measurement of biological processes at the molecular and cellular levels in humans and other living systems”, can play pivotal roles in disease diagnosis, treatment efficacy assessment, drug discovery, and the understanding of fundamental biology. In addition, molecular imaging is also an extremely powerful tool in multiple disciplines of biomedical research (e.g. stem cell research, RNA interference, nanomedicine, gene/cancer therapy, etc.). The molecular imaging techniques routinely used in our research include positron emission tomography (PET), bioluminescence, fluorescence, magnetic resonance imaging (MRI), among others.
近期论文
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Ni D, Ehlerding EB, Cai W. Multimodality imaging agents with PET as a fundamental pillar. Angewandte Chemie International Edition, 2018, in press.
Wei W, Ehlerding EB, Lan X, Luo Q, Cai W. Molecular imaging probes for diabetes: State of the art. Advanced Drug Delivery Reviews, 2018, revision.
Wei W, Ni D, Ehlerding EB, Luo Q, Cai W. PET imaging of receptor tyrosine kinases in cancer. Molecular Cancer Therapeutics, 2018, ePub.
Ferreira CA, Ni D, Rosenkrans ZT, Cai W. Scavenging of reactive oxygen and nitrogen species with nanomaterials. Nano Research, 2018, ePub. (NIHMSID 973775)
Wei W, Jiang D, Ehlerding EB, Luo Q, Cai W. Noninvasive PET imaging of T cells. Trends in Cancer, 2018, 4, 359-373. (NIHMSID 963358)
Chakravarty R, Siamof CM, Dash A, Cai W. Targeted α-therapy of prostate cancer using radiolabeled PSMA inhibitors: A game changer in nuclear medicine. American Journal of Nuclear Medicine and Molecular Imaging, 2018, in press.
Shi S, Chen F, Goel S, Graves SA, Luo H, Theuer CP, Engle JW, Cai W. In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell Structured Silica Nanosystem.Nano-Micro Letters, 2018, in press.
Ferreira CA, Hernandez R, Yang Y, Valdovinos HF, Engle JW, Cai W. ImmunoPET of CD146 in a Murine Hindlimb Ischemia Model. Molecular Pharmaceutics, 2018, ePub. (NIHMSID 974747)
Aluicio-Sarduy E, Ellison PA, Barnhart TE, Cai W, Nickles RJ, Engle JW. PET radiometals for antibody labeling. Journal of Labelled Compounds and Radiopharmaceuticals, 2018, ePub. (NIHMSID 973763)
Chen F, Goel S, Shi S, Barnhart TE, Lan X, Cai W. General Synthesis of Silica-based Yolk/shell Hybrid Nanomaterials and In Vivo Tumor Vasculature Targeting. Nano Research, 2018, ePub. (NIHMSID 964872)
Ehlerding EB, Ferreira CA, Aluicio-Sarduy E, Jiang D, Lee HJ, Theuer CP, Engle JW, Cai W. 86/90Y-based theranostics targeting angiogenesis in a murine breast cancer model. Molecular Pharmaceutics, 2018, 2018, ePub. (NIHMSID 973769)
Zhan Y, Ehlerding EB, Shi S, Graves SA, Goel S, Engle JW, Liang J, Cai W. Intrinsically Zirconium-89-Labeled Manganese Oxide Nanoparticles for In Vivo Dual-Modality Positron Emission Tomography and Magnetic Resonance Imaging. Journal of Biomedical Nanotechnology, 2018, 14, 900-909.(PMCID: PMC6007016)
Kang L, Jiang D, England CG, Barnhart TE, Yu B, Rosenkrans ZT, Wang R, Engle JW, Xu X, Huang P, Cai W. ImmunoPET imaging of CD38 in murine lymphoma models using 89Zr-labeled daratumumab. European Journal of Nuclear Medicine and Molecular Imaging, 2018, 45, 1372-1381.(PMCID: PMC5994170)
Ni D, Jiang D, Ehlerding EB, Huang P, Cai W. Radiolabeling silica-based nanoparticles via coordination chemistry: basic principles, strategies, and applications. Accounts of Chemical Research, 2018, 51, 778-788.(PMCID: PMC5878690)
Lyu Z, Kang L, Buuh ZY, Jiang D, McGuth JC, Du J, Wissler HL, Cai W, Wang RE. A switchable site-specific antibody conjugate. ACS Chemical Biology, 2018, 15, 13, 958-964.(PMCID: PMC5910183)
Ehlerding EB, Cai W, Grodzinski P, Liu C. Big potential from small agents: nanoparticles for imaging-based companion diagnostics. ACS Nano, 2018, 12, 2106-2121.(PMCID: PMC5878691)
Xu C, Chen F, Valdovinos HF, Jiang D, Goel S, Yu B, Sun H, Barnhart TE, Moon JJ, Cai W. Bacteria-like mesoporous silica-coated gold nanorods for positron emission tomography and photoacoustic imaging-guided chemo-photothermal combined therapy. Biomaterials, 2018, 165, 56-65.(PMCID: PMC5880312)
Liu B, Jones M, Kong L, Noel T, Jeng EK, Shi S, England CG, Alter S, Miller JS, Cai W, Rhode PR, Wong HC. Evaluation of the biological activities of the IL-15 superagonist complex, ALT-803, following intravenous versus subcutaneous administration in murine models. Cytokine, 2018, 107, 105-112.(PMCID: PMC5916319)
Kang L, Jiang D, Ehlerding EB, Barnhart TE, Ni D, Engle JW, Wang R, Huang P, Xu X, Cai W. Noninvasive trafficking of brentuximab vedotin and PET imaging of CD30 in lung cancer murine models. Molecular Pharmaceutics, 2018, 15, 1627-1634.(PMCID: PMC5920523)
Yu B, Goel S, Ni D, Ellison PA, Jiang D, Kang L, Cheng L, Liu Z, Yu F, Barnhart TE, Huang P, He Q, Cai W. Positron Emission Tomography Imaging of Cell Membranes Cross-Linked Nano Micelles Excreted via a Hepatobiliary Route. Advanced Materials, 2018, 30, 1704934.(PMCID: PMC5878718)
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