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Minhao Huang,# Yongjun Huang,# Jing Guo,# Lei Yu, Yu Chang, Xiaolu Wang, Jinfeng Luo, Yanhui Huang, Zhengchao Tu, Xiaoyun Lu, Yong Xu, Zhimin Zhang,* Zhang Zhang,* Ke Ding,*Pyrido[2, 3-d]pyrimidin-7(8H)-ones as New Selective Orally Bioavailable Threonine Tyrosine Kinase (TTK) Inhibitors , EUR J MED CHEM, https://doi.org/10.1016/j.ejmech.2020.113023 (IF=4.816)
Liang Jiang†, Yuting Wang†, Qian Li†, Zhengchao Tu, Sihua Zhu, Sanfang Tu*, Zhang Zhang*, Ke Ding*, Xiaoyun Lu*,Design, synthesis, and biological evaluation of Bcr-Abl PROTACs to overcome T315I mutation, Acta Pharmaceutica Sinica B, 2020,DOI: 10.1016/j.apsb.2020.11.009 (IF=7.01)
Yunxin Duan# , Jie Wang# , Sihua Zhu, Zheng-Chao Tu , Zhang Zhang*, Shingpan Chan*, Ke Ding*, Design, Synthesis, and Structure-Activity Relationships (SAR) of 3-Vinylindazole Derivatives as New Selective Tropomyosin Receptor Kinases (Trk) Inhibitors, EUR J MED CHEM, DOI: 10.1016/j.ejmech.2020.112552 (IF=4.816)
Shenyang Cui#, Yongjin Wang#, Yuting Wang#, Xia Tang, Jinfeng Luo, Xiaomei Ren, Lei Zhang, Zheng-Chao Tu, Yong Xu, Zhang Zhang*, Zhimin Zhang*, Xiaoyun Lu*, Ke Ding*, Design, Synthesis and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-2- methylbenzamides as New Tropomyosin receptor kinase (Trk) Inhibitors, EUR J MED CHEM, 2019, 179:470-482. (IF=4.816)
Li Tan#, Zhang Zhang#, Donglin Gao#, Shingpan Chan, Jinfeng Luo, Zheng-Chao Tu, Zhi-Min Zhang, Ke Ding, Xiaomei Ren*, Xiaoyun Lu*.Quinolone Antibiotic Derivatives as New Selective Axl Kinase Inhibitors. EUR J MED CHEM, 2019, 166:318-327. (IF=4.816)
Jian Zou#, Zhang Zhang#,*, Fang Xu#, Shengyang Cui, Chunli Qi, Jingfeng Luo, Zhen Wang, Xiaoyun Lu, Zhengchao Tu, Xiaomei Ren, Liyan Song*, Ke Ding*.GZD2202, a novel TrkB inhibitor, suppresses BDNF-mediated proliferation and metastasis in neuroblastoma models. J Drug Target., 2019, 27(4):442-450. (IF=3.408)
Qiuju Xun #, Zhang Zhang #, Jinfeng Luo, Linjiang Tong, Jian Zou, Yong Xu, Hua Xie, Xiaoyun Lu*, Ke Ding*. Structure-Based Design of 2-Oxo-3, 4-dihydropyrimido [4, 5-d] Pyrimidines as Novel Colony Stimulating Factor-1 Receptor (CSF1R) Kinase Inhibitors. Journal of Medicinal Chemistry. 2018, doi: 10.1021/acs.jmedchem.7b01612. (IF=6.259)
Zhang Zhang, Ren Xiaomei, Lu Xiaoyun, Wang Deping, Hu Xianjing, Zheng Yi, Song Liyan ,Pang Hongwen,Yu Rongmin*,Ding Ke*, GZD856, a novel potent PDGFRα/β inhibitor, suppresses the growth and migration of lung cancer cells in vitro and in vivo. Cancer letters, 2016, 375:172-178 (IF=6.375);
Li Tan#, Zhang Zhang#, Donglin Gao, Jinfeng Luo, Zhenchao Tu, Zhengqiu Li, Lijie Peng,Xiaomei Ren,*and Ke Ding*, 4-Oxo-1, 4-Dihydroquinoline-3-Carboxamide Derivatives as Selective Axl Kinase Inhibitors, Journal of Medicinal Chemistry.2016, 59(14):6807-25(IF=5.889);
Xiaomei Ren#, Xiaofen Pan#, Zhang Zhang#, Deping Wang, Xiaoyun Lu, Yang Bai, Donghai Wen, Huoyou Long, Jinfeng Luo, Yubing Feng, Xiaoxi Zhuang, Fengxiang Zhang, Jianqi Liu, Fang Leng, Xingfen Lang, Zhengchao Tu, Jinxuan Pan and Ke Ding*.Identification of GZD824 as an orally bioavailable Bcr-Abl inhibitor overcoming the clinically acquired gene mutation induced resistance against imatinib. Journal of Medicinal Chemistry. 2013, 56, 879-894(IF=5.889)。