Zhou, Ruhong - IBM Thomas J. Watson Research Center -

个人简介

Dr. Zhou is currently a Distinguished Research Staff Scientist (DRSM) and Head of Soft Matter Science Dept, at IBM Research, as well as an Adjunct Professor at Department of Chemistry, Columbia University. He received his Ph.D. in Chemistry from Columbia University (with Prof. Bruce Berne) in 1997. His current research interests include development of novel algorithms for computational biology and bioinformatics, protein folding dynamics, protein-protein interaction, ligand-receptor binding, as well as protein-nanoparticle interactions (nanotoxicity/nanomedicine). He has published 220+ peer-reviewed papers and 26 patents, and delivered 150+ invited talks worldwide. He was part of the core IBM Blue Gene team which won the 2009 National Medal on Technology (issued by President Obama). He also won the IBM Outstanding Technical Achievement Award (OTAA), the highest IBM technical award, in 2005, 2008, 2014 and 2016, and IBM Outstanding Innovation Award (OIA) in 2012, 2017 and the DEC Award from American Chemical Society (ACS). He serves as Editor-in-Chief of Current Physical Chemistry, Editor of (Nature) Scientific Reports, Guest Editor for Nanoscale (2011), and Editorial Board Member of 5 other international journals. He sits on the Board of Directors of Telluride Science and Research Center (TSRC), and the Scientific Advisory Board of Center for Multiscale Theory and Simulation, University of Chicago. He was elected to AAAS Fellow and APS Fellow in 2011, and IBM Distinguished RSM in 2014.

研究领域

The main research theme of my group is to understand the relationship between protein sequence, structure, and function, which is of fundamental importance in life science and the health care industry. We address important questions and problems in biophysics, structural biology, and biomolecular dynamics, using computational biology and bioinformatics approaches. In particular, we develop methodologies and techniques for molecular dynamics simulations with massively parallel supercomputers such as the IBM Blue Gene, and other high performance computing (HPC) platforms such as Cognitive Computing Cluster (CCC). The group pursues a broad but well grounded approach to leverage and expand upon our existing techniques for scientific and technological advancement. The current research projects in my group include: (1). Development of novel methods for molecular dynamics and multi-scale modeling of complex biological systems. (2). Free energy perturbation (FEP) methods for large scale protein-protein, protein-ligand binding affinity predictions. (3) Infectious disease modeling with both statistical models and physics-based models. (4) Molecular mechanisms of protein (mis)folding, aggregation, and associated diseases such as Alzheimer's Disease (AD) and Huntington's Disease (HD). (5) Interactions of nanoparticles with macrobiomolecules such as proteins, DNA/RNAs, and membranes (nanotoxicity and nanomedicine modeling).

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Diego Chowell, Luc GT Morris, Claud M Grigg, Jeffrey K Weber, Robert M Samstein, Vladimir Makarov, Fengshen Kuo, Sviatoslav M Kendall, David Requena, Nadeem Riaz, Benjamin Greenbaum, James Carroll, Edward Garon, David M Hyman, Ahmet Zehir, David Solit, Michael Berger, R. H. Zhou, Naiyer A Rizvi, Timothy A Chan, Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy, Science, 359, 582-587, 2018 Ge Fang, Weifeng Li, Xiaomei Shen, Jose Manuel Perez-Aguilar, Yu Chong, Xingfa Gao, Zhifang Chai, Chunying Chen, Cuicui Ge, and R. H. Zhou, Differential Pd-Nanocrystal Facets Demonstrate Distinct Antibacterial Activity against Gram-positive and Gram-negative Bacteria, Nature Communications, 9, 129, 2018 Alok V. Joglekar, Zhe Liu, Jeffrey K. Weber, Yong Ouyang, John D. Jeppson, Won Jun Noh, Pedro A. Lamothe-Molina, Huabiao Chen, Seung-gu Kang, Michael T. Bethune, R. H. Zhou, Bruce D. Walker, David Baltimore, HIV-specific T cell receptors from patients with differential immunologic control are functionally indistinguishable, Proc. Natl. Acad. Sci., 115, 1877-1882, 2018 Hongsuk Kang, Zaixing Yang, and R. H. Zhou, Lanosterol Disrupts Aggregation of Human γD-Crystallin by Binding to the Hydrophobic Dimerization Interface, J. Am. Chem. Soc. 140, in press, 10.1021/jacs.8b03065, 2018 Daxiang Gui, Xing Dai, Zetian Tao, Tao Zheng, Xiangxiang Wang, Mark A Silver, Jie Shu, Lanhua Chen, Yanlong Wang, Tiantian Zhang, Jian Xie, Lin Zou, Yuanhua Xia, Jujia Zhang, Jin Zhang, Ling Zhao, Juan Diwu, R. H. Zhou, Zhifang Chai, Shuao Wang, Unique Proton Transportation Pathway in a Robust Inorganic Coordination Polymer Leading to Intrinsically High and Sustainable Anhydrous Proton Conductivity, J. Am. Chem. Soc. 140, 6146-6155, 2018 Zonglin Gu, Leigh D. Plant, Xuan-Yu Meng, Jose Manuel Perez-Aguilar, Zegao Wang, Mingdong Dong, Diomedes E. Logothetis, and R. H. Zhou, Exploring the Nanotoxicology of MoS2: A Study on the Interaction of MoS2 Nanoflake and K+ Channels, ACS Nano, 12, 705-717, 2018 Binquan Luan and R. H. Zhou, Spontaneous Transport of Single-Stranded DNA through Graphene–MoS2 Heterostructure Nanopores, ACS Nano, 12, 3886-3891, 2018 Binquan Luan and R. H. Zhou, Single-File Protein Translocations through Graphene–MoS2 Heterostructure Nanopores, J. Phys. Chem. Lett. 9, 3409–3415, 2018 Yunjie Zhou, Yue Sun, Cheng Zhu, Yang Liu, Xing Dai, Jun Zhong, Qiongyang Chen, He Tian, R. H. Zhou, Zhenhui Kang, C–O−–K+(Na+) groups in non-doped carbon as active sites for the oxygen reduction reaction, J. Mater. Chem. A 6, 8955-8961, 2018 Xia Wang, Yanlong Wang, Xing Dai, Mark A Silver, Wei Liu, Yuxiang Li, Zhuanling Bai, Daxiang Gui, Lanhua Chen, Juan Diwu, R. H. Zhou, Zhifang Chai, Shuao Wang, Phase transition triggered aggregation-induced emission in a photoluminescent uranyl–organic framework, Chem. Comm. 54, 627-630, 2018 Xiaochuan Ma, Sangyun Lee, Xingshu Fei, Ge Fang, Tien Huynh, Yu Chong, Zhifang Chai, Cuicui Ge, R. H. Zhou, Inhibition of the proteasome activity by graphene oxide contributes to its cytotoxicity, Nanotoxicology, 12, 185-200, 2018 Jing Liu, Seung-gu Kang, Peng Wang, Yue Wang, Xiaonan Lv, Ying Liu, Fei Wang, Zonglin Gu, Zaixing Yang, Jeffrey K Weber, Ning Tao, Zhihai Qin, Qing Miao, Chunying Chen, R. H. Zhou, Yuliang Zhao, Molecular mechanism of Gd@C82(OH)22 increasing collagen expression: Implication for encaging tumor, Biomaterials, 152, 24-36, 2018 David R. Bell, Seung-gu Kang, Tien Huynh, R. H. Zhou, Concentration-dependent binding of CdSe quantum dot on SH3 domain, Nanoscale, 10, 351-358, 2018 Serena H. Chen, Seung-gu Kang, Judong Luo, R. H. Zhou, Charging Nanoparticles: Increased Binding of Gd@ C82 (OH) 22 Derivatives to Human MMP-9, Nanoscale, 10, 5667-5677, 2018 Dongfang Ma, Xuan-Yu Meng, David R. Bell, Shengtang Liu, R. H. Zhou, Inhibition of CYP2C8 by metallofullerenol Gd@C82(OH)22 through blocking substrate channels and substrate recognition sites, Carbon 127, 667-675, 2018 Wei Liu, Xing Dai, Jian Xie, Mark Silver, Duo Zhang, Yanlong Wang, Yawen Cai, Juan Diwu, Jian Wang, R. H. Zhou, Zhifang Chai, Shuao Wang, Highly Sensitive Detecting of UV Radiation using a Uranium Coordination Polymer, ACS Appl. Mater. Interface, 10, 4844–4850, 2018 Daxiang Gui, Xing Dai, Tao Zheng, Xiangxiang Wang, Mark A Silver, Lanhua Chen, Chao Zhang, Juan Diwu, R. H. Zhou, Zhifang Chai, Shuao Wang, An Ultrastable Heterobimetallic Uranium(IV)/Vanadium(III) Solid Compound Protected by a Redox-Active Phosphite Ligand: Crystal Structure, Oxidative Dissolution, and First-Principles Simulation, Inorg. Chem. 57, 903-907, 2018 Yaxing Wang, Huangjie Lu, Xing Dai, Tao Duan, Xiaojing Bai, Yawen Cai, Xuemiao Yin, Lanhua Chen, Juan Diwu, Shiyu Du, R. H. Zhou, Zhifang Chai, Thomas E Albrecht-Schmitt, Ning Liu, Shuao Wang, Facile and Efficient Decontamination of Thorium from Rare Earths Based on Selective Selenite Crystallization, Inorg. Chem. 57, 1880, 2018 Shulin Zhuang, Leili Zhang, Tingjie Zhan, Liping Lu, Lu Zhao, Haifei Wang, Joseph A Morrone, Weiping Liu, R. H. Zhou, The Binding Specificity Determines the Cytochrome P450 3A4-Mediated Enantioselective Metabolism of Metconazole, J. Phys. Chem. B 122, 1176-1184, 2018 Jeffrey K Weber, Seung-gu Kang, R. H. Zhou, Rare Dissipative Transitions Punctuate the Initiation of Chemical Denaturation in Proteins, Biophys. J. 114, 812-821, 2018