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个人简介

张金凤,中共党员,湖南湘潭人,博士,北京理工大学生命学院副教授/特别研究员,博士生导师。研究领域为高效低毒全活性纳米药物的制备及其生物医学应用研究。在ACS Nano, Nano Lett., Adv. Funct. Mater., Angew. Chem. Int. Ed., Biomaterials, Small, Theranostics, ACS Appl. Mater. Interfaces等国际著名学术期刊上发表SCI论文50余篇,总引用1800余次(H index = 25);其中以通讯或第一作者发表论文28篇(单篇平均IF>9),其中5篇为编辑推荐封面文章,影响因子>10的论文11篇,入选Wiley期刊 TOP Downloaded Paper(2019)。目前申请/授权国家发明专利8项(已获转让2项)、授权美国发明专利1项,编写英文专著章节1部;主持国家自然科学基金、北京市自然科学基金等项目5项,入选北京市科协青年人才托举工程项目(2021);曾获香港城市大学最佳博士毕业论文奖、周亦卿研究生院奖、CityU卓越学术研究一等奖、杰出学术成就奖、北京市优秀毕业生等多个奖项。受邀担任国际期刊Frontiers in Chemistry、Journal of Nanoelectronics and Optoelectronics客座编辑;长期担任ACS Nano, Adv. Funct. Mater., Biomaterials, ACS Appl. Mater. Inter., Adv. Healthc. Mater., Theranostics, Mol. Pharm.及Wiley book等三十余个国际知名期刊审稿人。 教育经历 2014.07-2017.07 哲学博士,生物与化学系,香港城市大学, (导师:Prof. Chun-Sing LEE) 2010.09-2013.06 理学硕士(推荐免试),有机化学,中科院理化技术研究所(导师:张晓宏教授) 2006.09-2010.06 工学学士,化学工程与工艺,中国矿业大学 (北京) 工作经历 2018.09-至今 副教授/特别研究员,生命学院,北京理工大学 2017.08-2018.08 高级副研究员/博士后研究员,化学系,香港城市大学 2013.12-2014.06 研究助理,物理与材料科学系,香港城市大学 2013.07-2013.12 研究助理,中国科学院理化技术研究所 获奖及荣誉 2021年,北京理工大学第十五届我爱我师十大“我最喜爱老师”称号 2020年,北京理工大学求是书院“优秀学育导师组长”(即优秀班主任) 2017年,香港城市大学优秀毕业论文奖(全系唯一) 2017年,第七届ChinaNANO国际会议最佳墙报奖 2016 & 2015年,香港城市大学杰出学术成就奖 2015年,香港城市大学周亦卿研究生院奖(全系唯一) 2015年,第一届ICOBAN纳米材料生物医学应用国际会议最佳墙报奖 2015年,香港城市大学学术研究卓越一等奖(全系唯一) 2011年,中国科学院研究生院三好学生 2010年,北京市优秀毕业生

研究领域

(1)基于超分子自组装的全活性纳米药物及纳米诊疗剂的制备及其结构、性能调控 (2)基于生物光子学的纳米诊疗剂的设计及其生物医学应用,涉及近红外/双光子成像、荧光寿命成像、光声成像及光动力、光热治疗等多种方式,实现对重大疾病的精准诊疗 (3)基于联合治疗模式(包括化疗、光疗、铁死亡、基因治疗、免疫治疗或联合治疗等)的纳米药物递送系统的设计及其用于不同疾病的诊疗研究,涉及癌症、动脉粥样硬化、神经退行性疾病、炎症性肠病、急性肝衰竭(肝再生)等疾病,进一步推动高效低毒的纳米药物递送系统的临床转化

近期论文

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Xiao Cui#, Guihong Lu#, Fang Fang, Yuan Xiong, Shuang Tian, Yingpeng Wan, Yafang Xiao, Dong Shen, Hui Wang, Jinfeng Zhang*, Chun-Sing Lee*, Iron Self-Boosting Polymer Nanoenzyme for Low-Temperature Photothermal-Enhanced Ferrotherapy. ACS Appl. Mater. Interfaces 2021, 13, just accepted. (IF: 8.758, 一区TOP) Yinfeng Zhang#, Fang Fang#, Yongjie Chen#, Min Li, Li Li, Wenyue Li*, Jinfeng Zhang*, Hollow Mesoporous Polyaniline Nanoparticles with High Drug Payload and Robust Photothermal Capability for Cancer Combination Therapy. Chin. J. Chem. Eng. 2021, 29, just accepted. (IF: 2.627, 二区) Xiaozhen Li#, Fang Fang#, Bo Sun, Chao Yin, Jihua Tan, Yingpeng Wan, Jinfeng Zhang*, Pengfei Sun, Quli Fan, Pengfei Wang, Shengliang Li*, Chun-Sing Lee*, Near-Infrared Small Molecule Coupled With Rigidness and Flexibility For High-Performance Multimodal Imaging-Guided Photodynamic and Photothermal Synergistic Therapy. Nanoscale Horiz. 2021, 6, 177-185. (IF: 9.927, 一区TOP) Li Huang, Shaojing Zhao, Fang Fang, Ting Xu, Minhuan Lan*, Jinfeng Zhang*, Advances and Perspectives in Carrier-free Nanodrugs for Cancer Chemo-Monotherapy and Combination Therapy. Biomaterials 2021, 268, 120557. (IF: 10.273, 一区TOP) Xiao Cui#, Guihong Lu#, Shengzhi Dong, Shengliang Li*, Yafang Xiao, Jinfeng Zhang*, Yanhong Liu, Xiangmin Meng, Feng Li*, Chun-Sing Lee*, Stable π-Radical Nanoparticles as Versatile Photosensitizer for Effective Hypoxia-Overcoming Photodynamic Therapy. Mater. Horiz. 2021, 8, 571-576. (IF: 12.319, 一区TOP) Yinfeng Zhang, Fang Fang, Li Li, Jinfeng Zhang*, Self-Assembled Organic Nanomaterials for Drug Delivery, Bioimaging, and Cancer Therapy. ACS Biomater. Sci. Eng. 2020, 6, 4816?4833. (IF: 4.152, 二区) Fang Fang#, Dongxu Zhao#, Yinfeng Zhang, Min Li, Jun Ye*, Jinfeng Zhang*, Europium-Doped Nanoparticles for Cellular Luminescence Lifetime Imaging via Multiple Manipulations of Aggregation State. ACS Appl. Bio Mater. 2020, 3, 5103?5110. (Featured on the Front Cover page) Yingpeng Wan#, Guihong Lu#, Wei-Chih Wei#, Yi-Hsuan Huang, Shengliang Li*, Jia-Xiong Chen, Xiao Cui, Ya-Fang Xiao, Xiaozhen Li, Yanhong Liu, Xiang-Min Meng, Pengfei Wang, Hai-Yan Xie, Jinfeng Zhang*, Ken-Tsung Wong*, Chun-Sing Lee*. Stable Organic Photosensitizer Nanoparticles with Absorption Peak beyond 800 Nanometers and High Reactive Oxygen Species Yield for Multimodality Phototheranostics. ACS Nano 2020, 14, 9917-992. (IF: 14.588, 一区TOP) Yinfeng Zhang, Li Li, Jinfeng Zhang*, Curcumin in Antidepressant Treatments: An Overview of Potential Mechanisms, Pre-Clinical/Clinical Trials and Ongoing Challenges. Basic Clin. Pharmacol. Toxicol. 2020, 127, 243-253. (IF: 2.651, 三区) Fang Fang, Min Li, Jinfeng Zhang*, Chun-Sing Lee*, Different Strategies for Organic Nanoparticle Preparation in Biomedicine. ACS Materials Lett. 2020, 2, 531?549. (即时IF: 8.1081, 一区TOP) Jingyi Liu#, Chao Liu#, Jinfeng Zhang#, Yunming Zhang, Keyin Liu, Ju-Xian Song, Sravan Gopalkrishnashetty Sreenivasmurthy, Ziying wang, Yesi Shi, Chengchao Chu, Yang Zhang, Caisheng Wu, Xianhua Deng, Xingyang Liu, Jing Song, Rongqiang Zhuang, Shuqiong Huang, Pengfei Zhang, Min Li*, Lei Wen*, Yunwu Zhang, and Gang Liu*, A Self-Assembled α-Synuclein Nanoscavenger for Parkinson’s Disease. ACS Nano 2020, 14, 1533-1549. (IF: 14.588, 一区TOP) Xiao Cui, Jinfeng Zhang*, Yingpeng Wan, Fang Fang, Rui Chen, Dong Shen, Zhongming Huang, Shuang Tian, Yafang Xiao, Xiaozhen Li, Jipsa Chelora, Yanhong Liu, Wenjun Zhang*, Chun-Sing Lee*, Dual Fenton Catalytic Nanoreactor for Integrative Type?I and Type-II Photodynamic Therapy Against Hypoxic Cancer Cells. ACS Appl. Bio Mater. 2019, 2, 3854-3860. Yingpeng Wan#, Guihong Lu#, Jinfeng Zhang*, Ziying Wang, Xiaozhen Li, Rui Chen, Xiao Cui, Zhongming Huang, Yafang Xiao, Jipsa Chelora, Wenjun Zhang, Yanhong Liu, Min Li, Hai-Yan Xie, Chun-Sing Lee*, A Biocompatible Free Radical Nanogenerator with Real-Time Monitoring Capability for High Performance Sequential Hypoxic Tumor Therapy. Adv. Funct. Mater. 2019, 29, 1903436. (Featured on the Front Cover page, IF: 16.836, 一区TOP) Jipsa Chelora, Jinfeng Zhang*, Yingpeng Wan, Xiao Cui, Junfang Zhao, Xiang-Min Meng, Pengfei Wang, Chun-Sing Lee*. Plant Derived Single-Molecule based Nanotheranostic for Photo-Enhanced Chemotherapy and Ferroptotic-Like Cancer Cell Death. ACS Appl. Bio Mater. 2019, 2, 2643-2649. Jinfeng Zhang, Fang Fang, Bin Liu, Ji-Hua Tan, Wen-Cheng Chen, Zelin Zhu, Yi Yuan, Yingpeng Wan, Xiao Cui, Shengliang Li*, Qing-Xiao Tong, Junfang Zhao, Xiang-Min Meng, and Chun-Sing Lee*. Intrinsically Cancer-Mitochondria-Targeted Thermally Activated Delayed Fluorescence Nanoparticles for Two-Photon-Activated Fluorescence Imaging and Photodynamic Therapy. ACS Appl. Mater. Interfaces 2019, 11, 41051-41061. (Featured on the Front Cover page, IF: 8.758, 一区TOP) Jinfeng Zhang, Weidong Nie, Rui Chen, Jipsa Chelora, Yingpeng Wan, Xiao Cui, Xiaohong Zhang*, Wenjun Zhang, Xianfeng Chen, Hai-Yan Xie, and Chun-Sing Lee*. Green Mass Production of Pure Nanodrugs via an Ice-Template-Assisted Strategy. Nano Lett. 2019, 19, 2, 658-665. (Featured on the Front Cover page, IF: 11.238, 一区TOP) Jinfeng Zhang, Jing Chen, Jingkun Ren, Weisheng Guo, Xianlei Li, Rui Chen, Jipsa Chelora, Xiao Cui, Yingpeng Wan, Xing-Jie Liang*, Yuying Hao*, Chun-Sing Lee*. Biocompatible Semiconducting Polymer Nanoparticles as Robust Photoacoustic and Photothermal Agents Revealing the Effects of Chemical Structure on High Photothermal Conversion Efficiency. Biomaterials 2018, 181, 92-102. (IF: 10.273, 一区TOP) Jinfeng Zhang, Jun Zhang, Wenyue Li, Rui Chen, Zhenyu Zhang, Wenjun Zhang, Yongbing Tang, Xiaoyuan Chen, Gang Liu*, Chun-Sing Lee*. Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy in Vitro and in Vivo. Theranostics 2017, 7, 3007-3020. (IF: 8.579, 一区TOP) Jinfeng Zhang, Caixia Yang, Rui Zhang, Rui Chen, Zhenyu Zhang, Wenjun Zhang, Shih-Hao Peng, Xiaoyuan Chen, Gang Liu*, Chain-Shu Hsu,* Chun-Sing Lee*. Biocompatible D-A Semiconducting Polymer Nanoparticle with Light-Harvesting Unit for Highly Effective Photoacoustic Imaging Guided Photothermal Therapy. Adv. Funct. Mater. 2017, 27, 1605094. (IF: 16.836, 一区TOP) Jinfeng Zhang#, Wencheng Chen#, Rui Chen, Xiao-Ke Liu, Yuan Xiong, Stephen V. Kershaw, Andrey L. Rogach, Chihaya Adachi*, Xiaohong Zhang, Chun-Sing Lee*. Organic Nanostructures of Thermally Activated Delayed Fluorescent Emitters with Enhanced Intersystem Crossing as Novel Metal-Free Photosensitizers. Chem. Commun. 2016, 52, 11744-11747. (Featured on the Front Cover page, IF: 5.996, 二区TOP) Jinfeng Zhang, Wencheng Chen, Sergii Kalytchuk, King Fai Li, Rui Chen, Chihaya Adachi*, Zhan Chen, Andrey L. Rogach, Guangyu Zhu, Peter K. N. Yu, Wenjun Zhang, Kok Wai Cheah, Xiaohong Zhang*, Chun-Sing Lee*. Self-Assembly of Electron Donor-Acceptor Based Carbazole Derivatives: Novel Fluorescent Organic Nanoprobes for Both One-Photon and Two-Photon Cellular Imaging. ACS Appl. Mater. Interfaces 2016, 8, 11355-11365. (IF: 8.758, 一区TOP) Jinfeng Zhang, Rui Chen, Zelin Zhu, Chihaya Adachi*, Xiaohong Zhang, Chun-Sing Lee*. Highly Stable Near-Infrared Fluorescent Organic Nanoparticles with A Large Stokes Shift for Noninvasive Long-Term Cellular Imaging. ACS Appl. Mater. Interfaces 2015, 7, 26266-26274. (IF: 8.758, 一区TOP) Jinfeng Zhang#, Yu-Chuan Liang#, Xudong Lin, Xiaoyue Zhu, Li Yan, Shengliang Li, Xia Yang, Guangyu Zhu, Andrey L. Rogach, Peter K. N. Yu, Peng Shi, Lung-Chen Tu, Chia-Ching Chang*, Xiaohong Zhang*, Xianfeng Chen, Wenjun Zhang, Chun-Sing Lee*. Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo. ACS Nano 2015, 9, 9741-9756. (IF: 14.588, 一区TOP) Jinfeng Zhang#, Shengliang Li#, Fei-Fei An, Juan Liu, Shubin Jin, Jin-Chao Zhang, Paul C. Wang, Xiaohong Zhang*, Chun-Sing Lee*, Xing-Jie Liang*. Self-Carried Curcumin Nanoparticles for in Vitro and in Vivo Cancer Therapy with Real-Time Monitoring of Drug Release. Nanoscale 2015, 7, 13503-13510. (IF: 6.895, 一区TOP) Minhuan Lan#, Jinfeng Zhang#, Xiaoyue Zhu, Pengfei Wang*, Xianfeng Chen*, Chun-Sing Lee, Wenjun Zhang*. Highly Stable Organic Fluorescent Nanorods for Living Cell Imaging. Nano Res. 2015, 8, 2380-2389. (IF: 8.183, 一区TOP) Jinfeng Zhang, Yanan Li, Fei-Fei An, Xiaohong Zhang*, Xianfeng Chen, Chun-Sing Lee*. Preparation and Size Control of Sub-100 nm Pure Nanodrugs. Nano Lett. 2015, 15, 313-318. (IF: 11.238, 一区TOP) Li Yan#, Jinfeng Zhang#, Chun-Sing Lee, Xianfeng Chen*. Micro- and Nanotechnologies for Intracellular Delivery. Small 2014, 10, 4487-4504. (IF: 11.459, 一区TOP) Jinfeng Zhang, Feifei An, Yanan Li, Caijun Zheng, Yinlong Yang, Xiujuan Zhang*, Xiaohong Zhang*. Simultaneous Enhanced Diagnosis and Photodynamic Therapy of Photosensitizer-Doped Perylene Nanoparticles via Doping, Fluorescence Resonance Energy Transfer, and Antenna Effect. Chem. Commun. 2013, 49, 8072-8074. (IF: 5.996, 二区TOP)

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