Fang, Chong - Oregon State University - Department of Chemistry

个人简介

Education:Chong Fang Post Doctoral Fellow, Department of Chemistry, University of California, Berkeley 2007-2010 Ph.D., Physical Chemistry and Biophysics, University of Pennsylvania 2006 BS, Chemistry and Computer Application, University of Science and Technology of China (USTC) 2001 Dr. Chong Fang grew up in Wuxi (a scenic town near Taihu Lake and Shanghai), China and received his B.S. in Chemistry and Computer Application (dual degree) from the University of Science and Technology of China (USTC) in 2001. He was awarded the Guo Moruo Scholarship, the highest undergraduate honor. He came across the Pacific and North American Continent to settle in Philadelphia, completed his graduate studies in the Department of Chemistry at University of Pennsylvania (Penn) and received his Ph.D. in 2006 under the advisorship of Prof. Robin M. Hochstrasser, Donner Professor of Physical Sciences and Member of the National Academy of Sciences. His graduate work focused on the structure and dynamics of helices in both water and membrane environments using the Two-Dimensional Infra-Red spectroscopy (2D IR). He was awarded the Dean’s Scholarship in 2005 from the School of Arts and Sciences at Penn. He stayed at Penn for a few months after graduation to complete an important project concerning the ultrafast relaxation dynamics of a drug molecule in complex with its enzyme target, the HIV-1 reverse transcriptase (HIV-1 RT). He then moved across the US to the west coast in 2007, and did his postdoctoral research at the Department of Chemistry in UC Berkeley with Prof. Richard A. Mathies, G. N. Lewis Professor of Chemistry and Dean of the College of Chemistry at Cal. His work on the fluorescence mechanism of GFP especially in the ultrafast time regime showcased the resolving power of the newly developed Femtosecond Stimulated Raman Spectroscopy (FSRS) targeting photosensitive biomolecules, and was featured on the Nature Cover in 2009. In summer 2010, Chong found his new home in Corvallis, Oregon and started his independent career as Assistant Professor of Chemistry at Oregon State University. His affiliation with ONAMI will strengthen collaborations on novel bio/nano-projects. He has a growing interest in tackling modern biophysical and biochemical problems using state-of-the-art vibrational spectroscopies in the femtosecond to picosecond domain, resolving their intrinsic motions that are functional, and facilitating future bioengineering and biomedical advances. In his mind, life is fulfilling while research is opportunistic and enjoyable with a vibrant group of young talents in this exciting field where chemistry, physics, optics meet biology. In September 2016, Dr. Fang was promoted to Associate Professor with Indefinite Tenure.

研究领域

The ultrafast spectroscopic techniques that I will develop and apply to a variety of important, clinically-relevant biological systems afford a prerogative opportunity to quantitatively explore the intricate and fundamental connection between structural dynamics and biological function at the molecular level, with great application potentials for the fields transcending chemistry, physics, biology, nanomaterial, bioengineering, and medicinal research. I’ll tackle the subtle yet significant issue of bridging the transition from ultrafast conformational fluctuations to structural intermediates that impact or further guide the system evolution, eventually leading to fascinating macroscopic functions. In other words, only the visualization and a deep understanding of the complex biomolecular systems in action can ensure a successful establishment of connections between the fundamental molecular mechanism and biological functions in cells and organisms.

近期论文

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Jessica J. Hong†, Liangdong Zhu†, Cheng Chen, Longteng Tang, Heng Jiang, Bei Jin, Trenton Gallagher, Qiubo Guo, Chong Fang*, and Xiulei Ji* (2019) "Dual Plating Battery via the Iodine/[ZnIx(OH2)4-x]2-x Cathode", Angew. Chem. Int. Ed., 58, Early View article (Sep. 20). DOI:10.1002/anie.201909324 and 10.1002/ange.201909324. (†Equal contribution.) Gregory Giesbers, Taylor Krueger, Jonathan Van Schenck, Ray Van Court, Jeffrey Morré, Chong Fang, Seri Robinson, and Oksana Ostroverkhova* (2019) "Fungi-derived xylindein: effect of purity on optical and electronic properties", MRS Adv., 4 (31-32), 1769-1777. DOI: 10.1557/adv.2019.269. Published online: 13 June 2019. Longteng Tang and Chong Fang* (2019) "Nitration of Tyrosine Channels Photoenergy Through A Conical Intersection in Water", J. Phys. Chem. B, 123 (23), 4915-4928. DOI: 10.1021/acs.jpcb.9b03464. Publication Date (Web): May 16, 2019. Published as part of The Journal of Physical Chemistry virtual special issue “Hai-Lung Dai Festschrift”. Miles A. Taylor, Liangdong Zhu, Nikita D. Rozanov, Kenneth T. Stout, Cheng Chen, and Chong Fang* (2019) "Delayed vibrational modulation of the solvated GFP chromophore into a conical intersection", Phys. Chem. Chem. Phys., 21 (19), 9728-9739. DOI: 10.1039/C9CP01077G. First published (Web) on 22 Apr 2019. This article is part of the themed collection: 2019 PCCP HOT Articles. Cheng Chen, Liangdong Zhu, Mikhail S. Baranov, Longteng Tang, Nadezhda S. Baleeva, Alexander Yu. Smirnov, Ilia V. Yampolsky, Kyril M. Solntsev, and Chong Fang* (2019) "Photoinduced Proton Transfer of GFP-Inspired Fluorescent Superphotoacids: Principles and Design", J. Phys. Chem. B, 123 (17), 3804-3821. DOI: 10.1021/acs.jpcb.9b03201. Publication Date (Web): April 9, 2019. Part of the "Young Scientists" virtual special issue (VSI) at the JPC journals. The introductory editorial of this VSI has been published in JPCA (August 29, 2019) with a Journal Cover [Volume 123, Number 34] featuring a collage of author pictures for the "Young Scientists in Physical Chemistry and Related Fields from around the World". Cheng Chen, Mikhail S. Baranov, Liangdong Zhu, Nadezhda S. Baleeva, Alexander Yu. Smirnov, Snizhana O. Zaitseva, Ilia V. Yampolsky, Kyril M. Solntsev, and Chong Fang* (2019) "Designing redder and brighter fluorophores by synergistic tuning of ground and excited states", Chem. Commun., 55 (17), 2537-2540. DOI: 10.1039/C8CC10007A. Publication Date (Web): February 5, 2019. Chong Zhang, John Holoubek, Xianyong Wu, Aigerim Daniyar, Liangdong Zhu, Cheng Chen, Daniel Leonard, Ismael Rodríguez-Pérez, Jia-Xing Jiang*, Chong Fang*, and Xiulei Ji* (2018) "A ZnCl2 Water-in-Salt Electrolyte for A Reversible Zn Metal Anode", Chem. Commun., 54 (100), 14097–14099. DOI: 10.1039/C8CC07730D. Publication Date (Web): November 21, 2018. Sean T. Tachibana, Longteng Tang, Liangdong Zhu, Weimin Liu, Yanli Wang, and Chong Fang (2018) "Watching an Engineered Calcium Biosensor Glow: Altered Reaction Pathways before Emission", J. Phys. Chem. B, 122 (50), 11986–11995. DOI: 10.1021/acs.jpcb.8b10587. Publication Date (Web): November 19, 2018. Longteng Tang, Liangdong Zhu, Miles A. Taylor, Yanli Wang, S. James Remington, and Chong Fang (2018) "Excited State Structural Evolution of a GFP Single-Site Mutant Tracked by Tunable Femtosecond Stimulated Raman Spectroscopy", Molecules, 23 (9), 2226. DOI: 10.3390/molecules23092226. Part of the Special Issue "Vibrational Probes of Biomolecular Structure and Dynamics". Longteng Tang, Liangdong Zhu, Yanli Wang, and Chong Fang (2018) "Uncovering the Hidden Excited State toward Fluorescence of an Intracellular pH Indicator", J. Phys. Chem. Lett., 9 (17), 4969-4975. DOI: 10.1021/acs.jpclett.8b02281. First published online 15 August 2018. Published in Issue 17 on September 6, 2018. [See also ACS LiveSlides™ presentation for this work, narrated by Dr. Longteng Tang. Posted online 7 September 2018.] Cheng Chen, Liangdong Zhu, and Chong Fang (2018) "Femtosecond Stimulated Raman Line Shapes: Dependence on Resonance Conditions of Pump and Probe Pulses", Chin. J. Chem. Phys., 31 (4), 492-502. DOI: 10.1063/1674-0068/31/cjcp1805125. Part of the Special Issue to commemorate the “ 60th anniversary of USTC and 30th anniversary of CJCP ” in 2018. Article first published online 18 July 2018. Published in Issue 4 on 27 August 2018. Chong Fang, Longteng Tang, Breland G. Oscar, and Cheng Chen (2018) "Capturing Structural Snapshots During Photochemical Reactions with Ultrafast Raman Spectroscopy: From Materials Transformation to Biosensor Responses" (Invited Perspective), J. Phys. Chem. Lett., 9 (12), 3253–3263. DOI: 10.1021/acs.jpclett.8b00373. First published online 25 May 2018. The Cover (JPCL Vol. 9, Iss. 12) went live on June 21, 2018. [See also ACS LiveSlides™ presentation for this work, narrated by Cheng Chen. Posted online 22 June 2018.] Longteng Tang, Yanli Wang, Liangdong Zhu, Karen Kallio, S. James Remington, and Chong Fang (2018) "Photoinduced proton transfer inside an engineered green fluorescent protein: A stepwise-concerted-hybrid reaction", Phys. Chem. Chem. Phys., 20 (18), 12517–12526. DOI: 10.1039/C8CP01907J. Published on Web: 24 April 2018. Published in Issue 18 on May 14, 2018. This article is part of the themed collection: 2018 PCCP HOT Articles and has now been made free to access until the end of March 2019. Longteng Tang, Yanli Wang, Liangdong Zhu, Che Lee, and Chong Fang (2018) "Correlated Molecular Structural Motions for Photoprotection After Deep-UV Irradiation", J. Phys. Chem. Lett., 9 (9), 2311–2319. DOI: 10.1021/acs.jpclett.8b00999. First published online 19 April 2018. Published in Issue 9 on May 3, 2018. [See also ACS LiveSlides™ presentation for this work, narrated by Dr. Longteng Tang. Posted online 16 May 2018.] Cheng Chen, Weimin Liu, Mikhail S. Baranov, Nadezhda S. Baleeva, Ilia V. Yampolsky, Liangdong Zhu, Yanli Wang, Alexandra Shamir, Kyril M Solntsev, and Chong Fang (2017) "Unveiling Structural Motions of a Highly Fluorescent Superphotoacid by Locking and Fluorinating the GFP Chromophore in Solution", J. Phys. Chem. Lett., 8 (23), 5921–5928. DOI: 10.1021/acs.jpclett.7b02661. Published on Web: 17 November 2017. Immediate Open Access via ACS AuthorChoice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. [See also ACS LiveSlides™ presentation for this work, narrated by Cheng Chen. Posted online 14 December 2017.] Breland G. Oscar, Cheng Chen, Weimin Liu, Liangdong Zhu, and Chong Fang (2017) "Dynamic Raman Lineshapes on an Evolving Excited State Landscape: Insights from Tunable Femtosecond Stimulated Raman Spectroscopy", J. Phys. Chem. A, 121 (29), 5428–5441. DOI: 10.1021/acs.jpca.7b04404. First published online 5 July 2017. Note: Published as part of The Journal of Physical Chemistry virtual special issue “Time-Resolved Vibrational Spectroscopy”. Longteng Tang, Yanli Wang, Weimin Liu, Yongxin Zhao, Robert E. Campbell, and Chong Fang (2017) "Illuminating Photochemistry of an Excitation Ratiometric Fluorescent Protein Calcium Biosensor", J. Phys. Chem. B, 121 (14), 3016–3023. DOI: 10.1021/acs.jpcb.7b01269. Published on Web: 22 March 2017. Published in print: 13 April 2017. Weimin Liu, Longteng Tang, Breland G. Oscar, Yanli Wang, Cheng Chen, and Chong Fang (2017) "Tracking Ultrafast Vibrational Cooling During Excited State Proton Transfer Reaction with Anti-Stokes and Stokes Femtosecond Stimulated Raman Spectroscopy", J. Phys. Chem. Lett., 8 (5), 997-1003. DOI: 10.1021/acs.jpclett.7b00322. First published online 14 February 2017. [See also ACS LiveSlides™ presentation for this work, narrated by Longteng Tang. Posted online 8 March 2017.] Sean R. Tachibana, Longteng Tang, Yanli Wang, Liangdong Zhu, Weimin Liu, and Chong Fang (2017) "Tuning calcium biosensors with a single-site mutation: Structural dynamics insights from femtosecond Raman spectroscopy", Phys. Chem. Chem. Phys., 19 (10), 7138-7146. DOI: 10.1039/C6CP08821J. Published on Web: Feb. 13, 2017. Liangdong Zhu, Sumit Saha, Yanli Wang, Douglas A. Keszler, and Chong Fang (2016) "Monitoring Photochemical Reaction Pathways of Tungsten Hexacarbonyl in Solution from Femtoseconds to Minutes", J. Phys. Chem. B, 120 (51), 13161-13168. DOI: 10.1021/acs.jpcb.6b11773. Published on Web: November 30, 2016. Published in Print: December 29, 2016.