余昊 - 华中科技大学

个人简介

余昊，2007年于中国科学技术大学获得物理学学士学位，2013年于加拿大University of Alberta获得物理学博士学位，主要研究方向为蛋白质折叠的单分子实验研究。2014至2017年在美国University of Colorado Boulder分校JILA研究所从事膜蛋白高分辨力谱相关方面的博士后研究。2017年加入华中科技大学物理学院任教授。长期从事生物物理实验研究，成果发表于Science，Proceedings of the National Academy of Sciences，Nucleic Acids Research，Nature Physics，Physical Review Letters等国际一流期刊。

研究领域

主要研究领域为单分子生物物理，致力于发展先进的力谱手段进行生物大分子动力学的实验研究。通过对单个生物分子、蛋白酶、分子伴侣、以及各类分子机器的操控与测量，我们揭示传统系综实验中无法观测的现象原理。我们研究力在生物分子结构转变过程中的作用，以期理解分子折叠与功能的关系、膜蛋白插入与折叠过程、分子错误折叠对疾病的影响、分子机器工作原理等问题。

近期论文

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H Yu, MGW Siewny, DT Edwards, AW Sanders, and TT Perkins, Hidden dynamics in the unfolding of individual membrane proteins. Science, 355, 945-950 (2017). K Neupane, DAN Foster, D Dee, H Yu, F Wang, MT Woodside, Direct observation of transition paths during the folding of proteins and nucleic acids. Science 532, 239-242 (2016). H Yu, D Dee, X Liu, AM Brigley, I Sosova, MT Woodside, Protein misfolding occurs by slow diffusion across multiple barriers in a rough energy landscape. Proc. Natl. Acad. Sci. USA 112, 8308-8313 (2015). H Yu, D Dee, MT Woodside, Single-molecule approaches to prion protein misfolding. Prion 7, 140-146 (2013). H Yu, AN Gupta, X Liu, K Neupane, AM Brigley, I Sosova, MT Woodside, Energy landscape analysis of native folding of the prion protein yields the diffusion constant, transition path time, and rates. Proc. Natl. Acad. Sci. USA 109, 14452-14457 (2012). K Neupane, DR Ritchie, H Yu, DAN Foster, F Wang, MT Woodside, Transition path times for nucleic acid folding determined from energy-landscape analysis of single-molecule trajectories. Phys. Rev. Lett. 109, 068102 (2012). H Yu, X Liu, K Neupane, AN Gupta, AM Brigley, A Solanki, I Sosova, MT Woodside, Direct observation of multiple misfolding pathways in a single prion protein molecule. Proc. Natl. Acad. Sci. USA 109, 5283-5288 (2012). AN Gupta, A Vincent, K Neupane, H Yu, F Wang, MT Woodside, Experimental validation of free-energy-landscape reconstruction from non-equilibrium single-molecule force spectroscopy measurements. Nature Physics 7, 631-634 (2011). K Neupane, H Yu, DAN Foster, F Wang, MT Woodside, Single-molecule force spectroscopy of the add adenine riboswitch relates folding to regulatory mechanism. Nucleic Acids Research 39, 7677-7687 (2011).