黄胜友 - 华中科技大学

个人简介

黄胜友，教授， 1998年获武汉大学物理学学士学位，2003年获武汉大学理学博士学位，博士毕业后于2003至2008年在美国密苏里大学道尔顿心血管研究中心从事生物分子的计算机建模、生物信息学与计算机药物设计的博士后研究，2008年提升为副研究员，2011年受聘为密苏里-哥伦比亚大学生物信息/超算中心和计算机科学系研究助理教授，2015年加入华中科技大学物理学院，聘为教授。长期从事计算生物物理和生物信息学方面的研究，在Nature Protocols, Proceedings of the National Academy of Sciences，Nucleic Acids Research， Bioinformatics，Drug Discovery Today，Physical Review Letters等国际一流期刊上发表SCI论文80余篇，其中第一和通讯作者50余篇，文章累计他引2000余次。所提出的集合分子对接算法和迭代打分函数模型被国际同行广泛采用，发展的蛋白质分子对接算法和打分函数模型在称为国际蛋白质相互作用预测的“奥林匹克竞赛”CAPRI评估中多次排名第一。入选国家海外高层次人才引进计划，获全国百篇优秀博士论文、中国大学生“五四”奖、湖北省自然科学一等奖、湖北省优秀博士论文、中国科学院奖学金、“宝钢”奖学金等多项奖励或荣誉。

研究领域

Our research interests are computational biophysics/biology/biochemistry, molecular modeling, and bioinformatics for complex interactions in biological systems for drug design and discovery. The primary research goals are to develop accurate scoring functions and efficient molecular docking algorithms for biomolecular interactions by combining physics- and bioinformatics-based methods.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Lei E,# Tao H,# Jiao S,# Yang A, Zhou Y, Wang M, Wen K, Wang Y, Chen Z, Chen X, Song J, Zhou C, Huang W, Xu L, Guan D, Tan C, Liu H, Cai Q, Zhou K, Modica J, Huang S-Y,* Huang W,* Feng X.* Potentiation of Vancomycin: Creating Cooperative Membrane Lysis through a "Derivatization-for-Sensitization" Approach. Journal of the American Chemical Society, 2022, doi: 10.1021/jacs.2c03784. Tao H, Wu Q, Zhao X, Lin P, Huang S-Y.* Efficient 3D conformer generation of cyclic peptides formed by a disulfide bond. Journal of Cheminformatics, 2022;14(1):26. Guo L,# He J,# Lin P, Huang S-Y,* Wang J.* TRScore: a three-dimensional RepVGG-based scoring method for ranking protein docking models. Bioinformatics, 2022: btac120. Yang A, Tao H, Szymczak LC, Lin L, Song J, Wang Y, Bai S, Modica J, Huang S-Y,* Mrksich M,* Feng X.* Efficient Enzymatic Incorporation of Dehydroalanine Based on SAMDI-Assisted Identification of Optimized Tags for OspF/SpvC. ACS Chemical Biology, 2022; 17(2):414-425. Li H, Yan Y, Zhao X, Huang S-Y.* Inclusion of Desolvation Energy into Protein-Protein Docking through Atomic Contact Potentials. Journal of Chemical Information and Modeling, 2022; 62(3):740-750.link Feng Y, Yan Y, He J, Tao H, Wu Q, Huang S-Y.* Docking and scoring for nucleic acid-ligand interactions: Principles and current status. Drug Discovery Today, 2022; 27(3):838-847. Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, Cheng Y, Liu A, Wu Q, Sun L, Xu F, Hu F, Chen L, Luo X, Feng Y, Huang S-Y, Hu J,* Wang G.* IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. Nature Communications, 12(1):3651, 2021. He J, Huang S-Y.,* Full-length de novo protein structure determination from cryo-EM maps using deep learning. Bioinformatics, doi: 10.1093/bioinformatics/btab357, 2021. Feng Y, Zhang K, Wu Q, Huang S-Y.* NLDock: a Fast Nucleic Acid-Ligand Docking Algorithm for Modeling RNA/DNA-Ligand Complexes. Journal of Chemical Information and Modeling, doi: 10.1021/acs.jcim.1c00341, 2021.link He J, Huang S-Y.* EMNUSS: a deep learning framework for secondary structure annotation in cryo-EM maps. Briefings in Bioinformatics, doi: 10.1093/bib/bbab156, 2021. Lensink MF, ..., Yan Y, Li H, Lin P, Huang S-Y, ..., Wodak SJ. Prediction of protein assemblies, the next frontier: The CASP14-CAPRI experiment. Proteins, 2021. doi: 10.1002/prot.26222. Yan Y, Huang S-Y.* Accurate prediction of inter-protein residue–residue contacts for homo-oligomeric protein complexes. Briefings in Bioinformatics, doi: 10.1093/bib/bbab038, 2021. Ma Z, Huang S-Y, Cheng F, Zou X.* Identification of Inhibitors and Prediction of Ligand Selectivity for Multiple Proteins: Application to Protein Kinases. The Journal of Physical Chemistry B, 125: 2288-2298, 2021. Li H, Huang S-Y.* Protein-protein docking with interface residue restraints. Chinese Physics B, 30: 018703, 2021. Yan Y,# Tao H,# He J, Huang S-Y.* The HDOCK server for integrated protein-protein docking. Nature Protocols, 15: 1829-1852, 2020. Wen Z, He J, Huang S-Y.* Topology-independent and global protein structure alignment through an FFT-based algorithm. Bioinformatics, 36: 478-486, 2020. He J, Tao H, Yan Y, Huang S-Y.*, Xiao Y.* Molecular Mechanism of Evolution and Human Infection with SARS-CoV-2. Viruses, 12: 428, 2020 Feng Y, Huang S-Y. ITScore-NL: An Iterative Knowledge-Based Scoring Function for Nucleic Acid-Ligand Interactions. Journal of Chemical Information and Modeling, 60(12):6698-6708, 2020. Tao H,# Zhang Y,# Huang S-Y.* Improving Protein-Peptide Docking Results via Pose Clustering and Rescoring with a Combined Knowledge-Based and MM-GBSA Scoring Function. Journal of Chemical Information and Modeling, 60: 2377-2387, 2020. Yan Y, He J, Feng Y, Lin P, Tao H, Huang S-Y.* Challenges and opportunities of automated protein-protein docking: HDOCK server vs human predictions in CAPRI Rounds 38-46. Proteins: Structure Function, and Bioinformatics, 88: 1055-1069, 2020.