刘颖 - 华中科技大学 - 生命科学与技术学院

个人简介

教育经历 1994-1998年南开大学生命科学学院，学士学位 1998-2003年北京大学生命科学学院，博士学位工作经历 2004.1-2007.9 耶鲁大学医学院，博士后 2007.10-2008.9 凯斯西储大学医学院生理与生物物理学系，博士后 2008.12-至今华中科技大学生命科学与技术学院，副教授

研究领域

主要研究领域是跨膜蛋白的分子生理学，主要从事钠离子碳酸氢根共转运体NCBT（Na-coupled bicarbonate transporter）相关的研究。NCBT属于SLC4家族，是重要的pH调控蛋白，具有极为重要的生理及病理学作用。我的研究主要包括两个方面：（1）NCBT的蛋白相互作用及其在NCBT功能调控中的作用；（2）NCBT在各种上皮细胞中的生理学作用，比如在中枢系统脉络膜、肾脏、消化道、生殖道等器官与系统上皮细胞的HCO3–跨膜运输中的作用。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Liu Y, Qin X, Wang DK, Gill HS, Guo YM, Parker MD, Chen LM*, Boron WF. Effects of optional structural elements,including two alternative amino termini and a new splicing cassette IV, on the function of NBCn1 (SLC4A7). The Journal of Physiology-London. 2013, 591(Pt 20):4983-5004. 2. Liu Y, Wang DK, Jiang DZ, Qin X, Xie ZD, Wang QK, Liu M, Chen LM*. Cloning and functional characterization of novel variants and tissue-specific expression of alternative amino and carboxyl termini of products of Slc4a10. PLoS ONE 2013; 8(2):e55974. 3. Chen LM, Qin X, Moss FJ, Liu Y, Boron WF*. Effect of simultaneously replacing putative TM6 and TM12 of human NBCe1-A with those from NBCn1 on surface abundance in Xenopus oocytes. Journal of Membrane Biology. 2012, 245(3): 131-40. 4. Liu Y, Wang DK, Chen LM*. The physiology of bicarbonate transporters in mammalian reproduction. Biology of Reproduction. 2012, 86(4):99, 1-13. 5. Liu Y, Xu JY, Wang DK, Wang L, Chen LM*. Cloning and identification of two novel NBCe1 splice variants from mouse reproductive tract tissues: A comparative study of NCBT genes. Genomics. 2011, 98:112-119. 6. Liu Y, Xu JY, Wang DK, Boron WF, Chen LM*. Expression and distribution of NBCn2 (Slc4a10) splice variants in mouse brain: cloning of novel variant NBCn2-D. Brain Research, 2011, 1390:33-40. 7. Chen LM*, Liu Y, Boron WF*. Role of an extracellular loop in determining the stoichiometry of Na/HCO3 cotransporters. The Journal of Physiology-London, 2011, 589(4) 877-890. 8. Liu Y*, Xu K, Chen LM, Sun X, Parker MD, Kelly ML, LaManna JC, Boron WF*. Distribution of NBCn2 (SLC4A10) splice variants in mouse brain. Neuroscience, 2010, 169(3):951-964. 9. Liu Y, Sun S, Chakrabarty T, Manuelidis L*. A rapid accurate culture assay for infectivity in Transmissible Encephalopathies. J Neurovirol, 2008, 14:1-9. 10. Sun R, Liu Y, Zhang H, Manuelidis L*. Quantitative recovery of scrapie agent with minimal protein from highly infectious cultures. Viral Immunol, 2008, 21(3):293-302.