个人简介
教育经历 1980.09 - 1984.07 华中师范大学 学士 1984.08 - 1987.08 湖南大学邵阳分校 助教 1987.09 - 1990.07 四川大学大学 硕士 1990.08 - 1999.08 华中师范大学 讲师 1999.09 - 2005.06 华中科技大学 博士 工作经历 2002.12 - 2004.12 德国萨尔大学 访问研究 2005.06 - 2005.11 华中科技大学 讲师 2005.11 - 2008.11 华中科技大学 副教授 2008.11 - 迄今 华中科技大学 教授
研究领域
主要从事神经生物物理、分子生物物理和细胞生物物理领域的研究。以模式生物线虫(C. elegans)为模型,研究动物感觉、行为、行为决策和脂肪代谢等的分子机制与调控,解析动物行为与决策的神经回路。
近期论文
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1. Meng LF, Chen L, Li ZY, Wu ZX*, Shan G*. Roles of MicroRNAs in the Caenorhabditis elegans Nervous System. J. Genet. Genomics, 2013, 40(9): 445-452. 2. Li ZY, Li YD, Yi YL, Huang WM, Yang S, Niu WP, Zhang L, Xu ZJ, Qu AL, Wu ZX*, Xu T*. Dissecting a central flip-flop circuit that integrates contradictory sensory cues in C. elegans feeding regulation. Nat. Commun., 3: 776, 2012(*,通讯作者) 3. Liu H, Wang X, Wang HD, Wu J, Ren J, Meng L, Wu Q, Dong H, Kao TY, Ge Q, Wu ZX, Yuh CH, Shan G*. Escherichia coli noncoding RNAs can affect gene expression and physiology of Caenorhabditis elegans. Nat. Commun., 3: 1073, 2012. 4. Jiu, YM, Yue Y, Yang S, Liu, L., Yu JW, Wu ZX*, and Xu T*. Insulin-like signaling pathway functions in integrative response to an olfactory and a gustatory stimuli in Caenorhabditis elegans. Protein Cell, 2010, 1(1): 75-81. 5. Li ZY, Zhou W, Wu ZX*, Zhang RY*, Xu T, Fabrication of size-controllable ultrasmall-disk electrode: Monitoring single vesicle release kinetics at tiny structures with high spatio-temporal resolution. Biosens. Bioelectron., 2009, 24(5): 1358-1364. 6. Hu ZT, Chen MR, Ping Z, Dong YM, Zhang RY, Xu T*, Wu ZX*. Synaptotagmin IV regulates dense core vesicle (DCV) release in LβT2 cells. Biochem. Biophys. Res. Commun., 2008, 371(4): 781-786. 7. Zhou KM, Dong YM, Ge Q, Zhu D, Zhou W, Lin XG, Liang T, Wu Z.X*, Xu T*. PKA activation bypasses the requirement for UNC-31 in the docking of dense core vesicles from C. elegans neurons. Neuron, 2007, 56(4): 657–669. 8. Stevens DR※, Wu ZX※, Matti U, Junge HJ, Schirra C, Becherer U, Wojcik SM, Brose N, Rettig J. Identification of the minimal protein domain required for priming activity of Munc13-1. Curr. Biol., 2005, 15(24): 2243-2248.(※,共同贡献作者) 9. Tian JH※, Wu ZX※, Unzicker M, Lu L, Cai Q, Li C, Schirra C, Matti U, Stevens D, Deng C, Rettig J, Sheng ZH. The role of Snapin in neurosecretion: snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells. J. Neurosci., 2005, 25(45): 10546-10555.