马聪 - 华中科技大学 - 生命科学与技术学院

个人简介

教育经历 1996-2000 中南民族大学化学系（本科） 2000-2003 华中科技大学环境科学与工程学院（硕士） 2004-2007华中科技大学生命科学与技术学院（博士）工作经历 2003-2004 德国慕尼黑大学访问学者 2007-2011美国德州大学西南医学中心博士后学术兼职中国生物物理学会 “膜与细胞生物物理分会”委员。

研究领域

大脑思考，学习和记忆的分子基础；突触形成和突触分泌的分子机制；神经系统重要膜蛋白的结构和功能；神经退行性疾病发病机理。

近期论文

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1. Li Y#, Wang S#, Li T, Zhu L, & Ma C*. Tomosyn guides SNARE complex formation in coordination with Munc18 and Munc13. FEBS Lett, doi:10.1002/1873-3468.13018 (2018). 2. Yao J#, Yang F#, Sun X, Wang S, Gan N, Liu Q, Liu D, Zhang X, Niu D, Wei Y, Ma C, Luo Z Q, Sun Q, Jia D*.Mechanism of inhibition of retromer transport by the bacterial effector RidL. Proc Natl Acad Sci U S A 115, E1446-E1454, doi:10.1073/pnas.1717383115 (2018). 3. Liu X#, Seven AB, Xu J, Esser V, Su L, Ma C, & Rizo J*.Simultaneous lipid and content mixing assays for in vitro reconstitution studies of synaptic vesicle fusion. Nat Protoc, 12(9), 2014-2028. doi:10.1038/nprot.2017.068(2017). 4. Li Y# ,Wang S#, Li T, Zhu L, Xu Y, Ma C*. A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13. Front Mol Neurosci. doi:10.3389/fnmol.2017.00256(2017). 5. Wang S#, Choi UB#, Gong J#, Yang X, Li Y, Wang AL, Yang X*, Brunger AT*, Ma C*. Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis.EMBO J 36, 816-829,doi: 10.15252/embj.201695775 (2017). 6. Liu X#, Seven AB#, Camacho M, Esser V, Xu J, Trimbuch T, Quade B, Su L, Ma C, Rosenmund C, Rizo J*. Functional synergy between the Munc13 C-terminal C1 and C2 domains. eLife, doi: 10.7554/eLife.13696(2016). 7. Wang S#, Y Li#, and Ma C*, Synaptotagmin-1 C2B domain interacts simultaneously with SNAREs and membranes to promote membrane fusion. Elife,doi: 10.7554/eLife.14211(2016). 8. Yang X#, Wang S#, Sheng Y#, Zhang M, Zou W, Wu L, Kang L, Rizo J, Zhang R, Xu T*,Ma C*. Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming. Nature structural & molecular biology 22, 547-554, doi:10.1038/nsmb.3038 (2015). 9. Ma C#*, Su L#, Seven AB, Xu Y ,Rizo J*. Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release. Science 339, 421-425, doi:10.1126/science.1230473 (2013，该论文入选2014年度“中国百篇最具国际影响学术论文”). 10. Ma C#, Li W#, Xu Y, Rizo J*. Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex. Nature structural & molecular biology 18, 542-549, doi:10.1038/nsmb.2047 (2011). 11. Li W#,Ma C#, Guan R, Xu Y, Tomchick DR*, Rizo J*.The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors. Structure 19, 1443-1455, doi:10.1016/j.str.2011.07.012 (2011). 12. Citri A#, Bhattacharyya S#,Ma C, Morishita W, Fang S, Rizo J, Malenka RC*. Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression. Journal of Neuroscience, 16437-16452, doi:10.1523/JNEUROSCI.4478-10.2010 (2010). 13. Pei J#, Ma C, Rizo J, Grishin NV. Remote homology between Munc13 MUN domain and vesicle tethering complexes. Journal of molecular biology 391, 509-517, doi:10.1016/j.jmb.2009.06.054 (2009). 14. Xue M#, Ma C#, Craig TK, Rosenmund C*, Rizo J*. The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function. Nature structural & molecular biology 15, 1160-1168, doi:10.1038/nsmb.1508 (2008).