罗亮 - 华中科技大学 - 生命科学与技术学院

个人简介

1997-2004 南开大学化学学院学士、硕士学位 2004-2009 美国纽约州立大学石溪分校化学系博士学位 2009-2012 美国明尼苏达大学化工材料系博士后 2012-2015 美国百时美施贵宝制药公司研究员 2016-至今华中科技大学生命科学与技术学院教授/博导 2015-2016 美国康涅尼格州中美医药开发协会会长 2017 国际期刊Bioengineering 副主编 2018 中国抗癌协会纳米肿瘤专业青年委员会副主任委员

研究领域

共轭聚合物采用主-客体策略成功合成了水溶性PDA。所得聚合物的晶体结构证明了PDA材料的优良性能。这种材料在pH条件下具有显著的显色性。经FITC或TPE-CN修饰后，材料对不同pH刺激表现出不同的荧光响应。因此，我们开发了一种新型的刺激响应功能材料。 AIE光敏剂研究开发了一种在肿瘤治疗中具有良好PDT作用的新型AIE分子，在光照射下可在15秒内诱导细胞凋亡。同时，荧光信号读出量的增加可以快速地原位评价其治疗反应。这种单分子不仅可以有效地进行PDT治疗，而且可以实时反馈其疗效，对评估和指导治疗具有重要意义。药物传递系统药物缓释平台的特点。A):装载DOX的LLC凝胶的累计DOX释放;B、C为不同配比(B: SPC:GDO = 50:50;c: SPC:GDO = 70:30)。比例尺:100μm缓释平台特点。A):装载DOX的LLC凝胶的累计DOX释放;B、C为不同配比(B: SPC:GDO = 50:50;c: SPC:GDO = 70:30)。范围:100μm

近期论文

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Recent progress on nanoparticle-based drug delivery systems for cancer therapy.Cancer Biology & Medicine.2017, Efficient Radical-Enhanced Intersystem Crossing in an NDI-TEMPO Dyad: Photophysics, Electron Spin Polarization, and Application in Photodynamic Therapy.CHEMISTRY-A EUROPEAN JOURNAL. Conformation-Dependent Manipulation of Human Islet Amyloid Polypeptide Fibrillation by Shiitake-Derived Lentinan.ACS Applied Materials & Interfaces.2018, Ultraeffective Inhibition of Amyloid Fibril Assembly by Nanobody–Gold Nanoparticle Conjugates.BIOCONJUGATE CHEMISTRY.2019, Oligotyrosines Inhibit Amyloid Formation of Human Islet Amyloid Polypeptide in a Tyrosine-Number-Dependent Manner.ACS Biomaterials Science & Engineering.2019, AIE-based theranostic systems for detection and killing of pathogens.Theranostics.2019, A Dual‐Functional Photosensitizer for Ultraefficient Photodynamic Therapy and Synchronous Anticancer Efficacy Monitoring.Advanced Functional Materials.2019, Exploiting Unsaturated Carbon-Iodine Compounds for the Preparation of Carbon-Rich Materials.ACCOUNTS OF CHEMICAL RESEARCH.2019, Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy.Nature Communications.2019, Dual-Color Emissive AIEgen for Specific and Label-Free Double-Stranded DNA Recognition and Single-Nucleotide Polymorphisms Detection.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY.2019, Polydiacetylene-based ultrastrong bioorthogonal Raman probes for targeted live-cell Raman imaging.Nature Communications.2020, Paclitaxel-Potentiated Photodynamic Theranostics for Synergistic Tumor Ablation and Precise Anticancer Efficacy Monitoring.ACS Applied Materials & Interfaces.2020, Spin-Orbit Charge Transfer Intersystem Crossing (SOCT-ISC) in Perylene-Bodipy Compact Electron Donor-Acceptor Dyads: ISC Mechanism and Application as Novel and Potent Photodynamic Therapy Reagents.CHEMISTRY-A EUROPEAN JOURNAL.2020, Recent advances on polydiacetylene-based smart Q1 materials for biomedical applications.Materials Chemistry Frontiers.2020, Tunable Two-Compartment On-Demand Sustained Drug Release Based on Lipid Gels.Journal of Pharmaceutical Sciences.2020, Electronic coupling and spin-orbit charge transfer intersystem crossing (SOCT-ISC) in compact BDP-carbazole dyads with different mutual orientations of the electron donor and acceptor.The Journal of Chemical Physics.2020, Thickness-Dependent Enhancement of Electronic Mobility of MoS2 Transistors via Surface Functionalization.Journal of Physical Chemistry C.2020, Liang Luo.Multicationic AIEgens for Unimolecular Photodynamic Theranostics and Two-Photon Fluorescence Bioimaging.Materials Chemistry Frontiers.2020, Liang Luo.Platinum-AIEgen Coordination Complex for Imaging-Guided Annihilation of Cisplatin-Resistant Cancer Cells.Chemical Communications.2020, Liang Luo.Near-Infrared AIE Dots with Chemiluminescence for Deep-Tissue Imaging.Advanced Materials.2020,