个人简介
教育经历
1992.9-1996.6,华中农业大学食品科技系,本科
1996.9-2001.6,华中农业大学食品科技系,博士
工作经历
2001.7-2003.6,华中科技大学生物医学工程博士后流动站,博士后
2006.5-2007.9,美国圣路易斯华盛顿大学医学院,博士后
2007.10-2009.5,美国明尼苏达大学Masonic 癌症中心,博士后
研究领域
主要从事纳米肿瘤学研究,特别侧重于采用生物来源纳米药物(如细胞分泌的微颗粒及外泌体载药系统)及肿瘤微环境响应的智能纳米药物来靶向肿瘤干细胞及改造肿瘤的免疫微环境,探讨其抗肿瘤作用及分子机制,并发展肿瘤综合治疗策略
近期论文
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Liang Q, Bie N, Yong T, Tang K, Shi X, Wei Z, Jia H, Zhang X, Zhao H, Huang W, Gan L*, Huang B*, Yang X*. The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency. Nature Biomedical Engineering, 2019, doi: 10.1038/s41551-019-0405-4.
Yong T, Zhang X, Bie N, Zhang H, Zhang X, Li F, Hakeem A, Hu J, Gan L*, Santos HA*, Yang X*. Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy. Nature Communications, 2019, 10(1):3838.
Yang H, Wang Q, Li Z, Li F, Wu D, Fan M, Zheng A, Huang B, Gan L*, Zhao Y*, Yang X*. Hydrophobicity-adaptive nanogels for programmed anticancer drug delivery. Nano Letters, 2018, 18(12):7909-7918.
Huang W, Zhao H, Wan J, Zhou Y, Xu Q, Zhao Y*, Yang X*, Gan L*. pH- and photothermal-driven multistage delivery nanoplatform for overcoming cancer drug resistance. Theranostics, 2019, 9(13):3825-3839.
Xu Q, Wan J, Bie N, Song X, Yang X, Yong T, Zhao Y, Yang X, Gan L. A biomimetic gold nanocages-based nanoplatform for efficient tumor ablation and reduced inflammation. Theranostics. 2018, 8(19):5362-5378.
Li F, Yang H, Bie N, Xu Q, Yong T, Wang Q*, Gan L*, Yang X. Zwitterionic temperature/redox-sensitive nanogels for near-infrared light-triggered synergistic thermo-chemotherapy. ACS Applied Materials & Interfaces, 2017, 9(28):23564-23573.
Yong T, Hu J, Zhang X, Li F, Yang H, Gan L*, Yang X. Domino-like intercellular delivery of undecylenic acid-conjugated porous silicon nanoparticles for deep tumor penetration. ACS Applied Materials & Interfaces. 2016, 8(41):27611-27621.
Yang H, Wang Q, Huang S, Xiao A, Li F, Gan L*, Yang X*. Smart pH/redox dual-responsive nanogels for on-demand intracellular anticancer drug release. ACS Applied Materials & Interfaces, 2016, 8(12):7729-7738.