陈历明 - 华中科技大学 - 生命科学与技术学院

个人简介

教育经历 1993.9−1997.7 北京大学，生命科学学院，理学士 1997.8−2002.7 北京大学，生命科学学院，理学博士工作经历 2002−2007 纽约大学及耶鲁大学，博士后 2007−2008 凯斯西储大学，资深研究助理(Senior Research Associate) 2008−2009 凯斯西储大学，讲师(Instructor) 2008−2015 华中科技大学生命科学与技术学院，副教授 2015−至今华中科技大学生命科学与技术学院，教授

研究领域

本课题组主要从事酸碱离子跨膜运输的生物物理学、生理及病理学研究，主要包括：（1）酸碱转运体蛋白的结构与功能（2）酸碱转运体的功能调控机制（3）酸碱转运体在中枢神经系统、消化系统、泌尿与生殖等系统中的生理学作用（4）酸碱平衡调控与各种疾病的关系，包括神经系统疾病、代谢性酸中毒、肿瘤及不孕不育等。

近期论文

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1. Yi-Min Guo#, Ying Liu#, Mei Liu, Jin-Lin Wang, Zhang-Dong Xie, Kang-Jing Chen, Deng-Ke Wang, Rossana Occipinti, Walter F. Boron, Li-Ming Chen*. Na+/HCO3– cotransporter NBCn2 mediates HCO3− reclamation in the apical membrane of renal proximal tubules. Journal of the American Society of Nephrology. Online on March 9th, 2017. (#equal contribution). (Highlighted by Nature Review Nephrology) 2. Zhenzhen Chen, Liwei Ding, Weili Yang, Junpei Wang, Liming Chen, Yongsheng Chang, Bin Geng, Qinghua Cui, Youfei Guan, Jichun Yang. Hepatic activation of the FAM3C-HSF1-CaM pathway attenuates hyperglycemia of obese diabetic mice. Diabetes. Feb 27th, 2017. 3. Ying Liu, Jichun Yang, Li-Ming Chen*. Structure and Function of SLC4 family HCO3– transporters. Frontiers in Physiology. 2015, 6:355. 4. Deng-Ke Wang#, Ying Liu#, Evan J. Myers, Yi-Min Guo, Zhang-Dong Xie, De-Zhi Jiang, Jia-Min Li, Jichun Yang, Mugen Liu, Mark D. Parker, Li-Ming Chen*. Effects of Nt-truncation and coexpression of isolated Nt domains on the membrane trafficking of electroneutral Na+/HCO3– cotransporters. Scientific Reports. 2015. 5: 12241, p.1−23. 5. Liu Y#, Qin X#, Wang DK, Gill HS, Guo YM, Parker MD, Chen LM*, Boron WF. Effects of optional structural elements, including two alternative amino termini and a new splicing cassette IV, on the function of NBCn1 (SLC4A7). Journal of Physiology. 2013, 591:4983-5004. 6. Liu Y#, Wang DK#, Jiang DZ#, Qin X, Xie ZD, Wang QK, Liu M, Chen LM*. Cloning and functional characterization of novel variants and tissue-specific expression of alternative amino and carboxyl termini of products of Slc4a10. PLoS ONE 2013; 8(2):e55974. 7. Liu Y, Wang DK, Chen LM*. The physiology of bicarbonate transporters in mammalian reproduction. Biology of Reproduction. 2012, 86(4):99, 1-13. 8. Chen LM*, Liu Y, Boron WF*. Role of an extracellular loop in determining the stoichiometry of Na/HCO3 cotransporters. Journal of Physiology, 2011, 589(4) 877-890. 9. Chen LM, Zhao J, Musa-Aziz R, Pelletier M, Drummond IA, Boron WF. Cloning and Characterization of a zebrafish cDNA homologue of human AQP1: A bifunctional water and gas channel. Am J Physiol-Regul Integr Comp Physiol 2010, 299(5):R1163-74. 10. Musa-Aziz R#, Chen LM#, Pelletier MF, Boron WF*. Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG. Proc Natl Acad Sci USA, 2009, 106(13):5406-5411. (#Co-first author)