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个人简介

靳水林,河北邢台人,哈尔滨工业大学数学学院教授,国家级高层次人才。数学、统计学博士生导师。哈尔滨工业大学青年科学家工作室负责人。 主持国家自然科学基金面上项目、青年基金项目、863项目、黑龙江省杰青等项目,入选哈工大理学创新培育计划;参与国家“生物安全”重大科技专项课题等。获得黑龙江自然科学一等奖。 教育经历 2009年9月-2012年9月 哈尔滨工业大学 博士后 2003年9月-2009年6月 吉林大学 博士 1999年9月-2003年6月 吉林大学 学士 工作经历 2019年12月-现在 哈尔滨工业大学 教授 2017年4月-现在 哈尔滨工业大学 博士生导师 2013年12月-2019年12月 哈尔滨工业大学 副教授 2009年6月-2013年12月 哈尔滨工业大学 讲师 2019年3月-2019年3月 加州大学欧文分校(UCI) 访问学者 2018年12月-2019年2月 哈佛大学 访问学者 2013年4月-2014年4月 哈佛大学 访问学者 2015年10月-2015年11月 明尼苏达大学 访问学者 科研项目 帕金森病相关的长链非编码RNA识别与功能分析方法研究 国家自然科学基金面上项目 主持 算子代数独立性的等价描述 国家自然科学基金青年基金 主持 算子代数独立性与R.Curto公开问题 黑龙江自然科学基金 主持 水污染诱发类癌症的致病机理研究—基于长链非编码RNA预测模型与算法 城市水资源与水环境国家重点实验室开放课题 主持 基于RNA-Seq分析的帕金森疾病机理研究 哈尔滨工业大学理学创新培育计划 主持 生物大数据表述索引、搜索与存储访问关键技术研发 国家863重大项目 子课题负责人 高等级病原微生物实验室信息管理关键技术与系统研发 国家重点研发计划 参与 基于生物数据融合的致病microRNA识别方法研究 国家自然科学基金 参与

研究领域

计算系统生物学,生物统计学,生物信息学

近期论文

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Yang Zhou, Qiongyu Sheng, Jing Qi, Jiao Hua, Bo Yang, Lei Wan, Shuilin Jin*. Accurate integration of multiple heterogeneous single-cell RNA-seq data sets by learning contrastive biological variation, Genome Research, 2023, 33(5): 750-762. Jing Qi, Qiongyu Sheng, Yang Zhou, Jiao Hua, Shutong Xiao, Shuilin Jin*. scMTD: a statistical multidimensional imputation method for single-cell RNA-seq data leveraging transcriptome dynamic information, Cell & Bioscience, 2022, 12(1): 1-15. Jing Qi, Yang Zhou, Zicen Zhao, Shuilin Jin*. SDImpute: A statistical block imputation method based on cell-level and gene-level information for dropouts in single-cell RNA-seq data, PLoS Computational Biology, 2021, 17(6): e1009118. Pingping Wang, Xiyun Jin, Wenyang Zhou, Meng Luo, Zhaochun Xu, Chang Xu, Yiqun Li, Kexin Ma, Huimin Cao, Yan Huang, Guangfu Xue, Shuilin Jin, Huan Nie, Qinghua Jiang. Comprehensive analysis of TCR repertoire in COVID-19 using single cell sequencing, Genomics, 2021, 113(2): 456-462. Jing Qi, Yang Zhou, Jiao Hua, Liying Zhang, Jialin Bian, Beibei Liu, Zicen Zhao, Shuilin Jin*. The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to SARS-CoV-2 infection, International Journal of Environmental Research and Public Health, 2021, 18(1): 284. Nan Wang , Jun Zhang , Li Xu, Jing Qi , Beibei Liu, Yiyang Tang, Yinan Jiang, Liang Cheng, Qinghua Jiang, Xunbo Yin, Shuilin Jin*. A novel estimator of between-study variance in random-effects models, BMC Genomics, 2020, 21(1): 149. Ruiyu Xiao, Guoshan Lu, Wanqian Guo, Shuilin Jin*. NDRindex: a method for the quality assessment of single-cell RNA-Seq preprocessing data, BMC bioinformatics, 2020, 21(16): 1-9. Yating He, Haihua Zhang, Tao Wang, Zhifa Han, Qing-bin Ni, Kun Wang, Longcai Wang, Yan Zhang, Yang Hu, Shuilin Jin, Bao-liang Sun, Guiyou Liu. Impact of serum calcium levels on Alzheimer’s disease: a Mendelian randomization study, Journal of Alzheimer's Disease, 2020, 76(2): 713-724. Longcai Wang, Yanchun Qiao, Haihua Zhang, Yan Zhang, Jiao Hua, Shuilin Jin, Guiyou Liu. Circulating vitamin D levels and Alzheimer’s disease: a Mendelian randomization study in the IGAP and UK Biobank, Journal of Alzheimer's Disease, 2020, 73(2): 609-618. Guiyou Liu, Yang Hu, Zhifa Han, Shuilin Jin*, Qinghua Jiang*. Genetic variant rs17185536 SIM1 gene expression in human brain hypothalamus, Proceedings of the National Academy of Sciences: PNAS, 2019, 116 (9): 3347-3348. Zhuo Wang, Shuilin Jin*, Chiping Zhang*, A method based on differential entropy-like function for detecting differentially expressed genes across multiple conditions in RNA-Seq studies, Entropy, 2019, 21(3): 242. Nan Wang, Ying Zhang, Li Xu, Shuilin Jin*, Relationship between Alzheimer's disease and the immune system: A meta-analysis of differentially expressed genes, Frontiers in Neuroscience, 2019, 12: 1026. Zhifa Han, Rui Tian, Peng Ren, Wenyang Zhou, Peng Wang, Shuilin Jin*, Qinghua Jiang*, Parkinson's disease and Alzheimer's disease: a Mendelian randomization study, BMC medical genetics, 2018, 19 (1), 215 Guiyou Liu, Shuilin Jin, Yang Hu, Qinghua Jiang*. Disease status affects the association between rs4813620 and the expression of Alzheimers disease susceptibility gene TRIB3. PNAS, 115(45), E10519-E10520 Zhifa Han#, Tao Wang#, Rui Tian, Wenyang Zhou, Pingping Wang, Peng Ren, Jian Zong, Yang Hu, Shuilin Jin*, Qinghua Jiang*. BIN1 rs744373 variant is significantly associated with Alzheimer’s disease in Caucasian but not East Asian populations. 2018. BMC Bioinformatics. (Accepted) Weiyue Ding, Li Xu, Lejun Zhang, Zhijie Han, Qinghua Jiang, Z Wang, Shuilin Jin*, Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus, BMC medical genetics, 19 (1), 38 Guiyou Liu, Y Zhao, Shuilin Jin, Yang Hu, Tao Wang, Rrui Tian, Zhifa Han, D Xu, Qinghua Jiang, Circulating vitamin E levels and Alzheimer’s disease: a Mendelian randomization study, Neurobiology of aging, 2018 Guiyou Liu, Tao Wang, Rrui Tian, Yang Hu, Zhifa Han, P Wang, W Zhou, P Ren, J Zong, Shuiiln Jin*, Qinghua Jiang*, Alzheimer’s Disease Risk Variant rs2373115 Regulates GAB2 and NARS2 Expression in Human Brain Tissues, Journal of Molecular Neuroscience, 2018, 1-7 Yang Hu, Shuilin Jin, Liang Cheng, Guiyou Liu, and Qinghua Jiang Autoimmune disease variants regulate GSDMB gene expression in human immune cells and whole blood, Proceedings of the National Academy of Sciences of the United States of America: PNAS, 2017. Zhuo Wang*, Shuilin Jin*, Guiyou Liu*, Xiurui Zhang, Nan Wang, Deliang Wu, Yang Hu, Chiping Zhang*, Qinghua Jiang*, Li Xu*, Yadong Wang*, DTWscore:differential expression and cell clustering analysis for time-series single-cell RNA-seq data, BMC Bioinformatics, 2017, 18:270. Guiyou Liu, Yang Hu, Shuilin Jin, Qinghua Jiang*, Genetic variant rs763361 regulates multiple sclerosis CD226 gene expression,Proceedings of the National Academy of Sciences of the United States of America: PNAS, 2017, 114(6): E906-E907. Jan Hamhalter, Shuilin Jin*, Operational independence and tensor products of C*-algebras, Journal of Mathematical Physics, 2017, 58(3):032303. Jiajie Peng, Kun Bai, Xuequn Shang, Guohua Wang, Hansheng Xue, Shuilin Jin, Liang Cheng, Yadong Wang, Jin Chen, Predicting disease-related genes using integrated biomedical networks, BMC Genomics, 2017, 18(Suppl 1): 1043. Yang Hu, Likun Zheng, Liang Cheng, Ying Zhang, Weiyang Bai, Wenyang Zhou, Tao Wang, Zhifa Han, Jian Zong, Shuilin Jin, Jun Zhang, Guiyou Liu, Qinghua Jiang, GAB2 rs2373115 variant contributes to Alzheimer@#%s disease risk specifically in European population, Journal of the Neurological Sciences, 2017, 375: 18-22. Shuilin Jin, et al. The complexity of promoter regions based on a vector topological entropy. Current Bioinformatics, 2016, 11. Yang Hu, Zhou W, Ren J, Dong L, Wang Y, Shuilin Jin*, Cheng L.Annotating the Function of the Human Genome with Gene Ontology and Disease Ontology. Biomed Res Int. 2016;2016:4130861. Qinghua Jiang*, Shuilin Jin*, Yongshuai Jiang, Mingzhi Liao, Rennan Feng, Liangcai Zhang, Guiyou Liu, Junwei Hao. Alzheimer@#%s disease variants with the genome-wide significance are significantly enriched in immune pathways and active in immune cells,Molecular Neurobiology, 54(1), 594-600. Guiyou Liu, Yang Hu, Shuilin Jin, Fang Zhang, Qinghua Jiang, Junwei Hao. Cis-eQTLs regulate reduced LST1 gene and NCR3 gene expression and contribute to increased autoimmune disease risk. Proceedings of the National Academy of Sciences of the United States of America:PNAS. 113, 42, E6321–E6322. Guoqiang Wan, Wenyang Zhou, Yang Hu, Rui Ma, Shuilin Jin, Guiyou Liu, and Qinghua Jiang. Transcriptional Regulation of lncRNA Genes by Histone Modification in Alzheimer’s Disease. 2016 (2016), 3164238. Wanqian Guo, Zizeng Yang, Juanshan Du, Renli Yin, Xianjiao Zhou, Shuilin Jin and Nanqi Ren. Degradation of sulfadiazine in water by a UV/O3 process: performance and degradation pathway. RSC Adv., 2016,6, 57138-57143 Qinghua Jiang,Jixuan Wang,Xiaoliang Wu,Rui Ma,Tianjiao Zhang,Shuilin Jin, Zhijie Han, Renjie Tan, Jiajie Peng, Guiyou Liu, Yu Li, Yadong Wang. LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression,Nucleic Acids Research,2015, 43(D1):D193-D196. Qinghua Jiang,Rui Ma,Jixuan Wang,Xiaoliang Wu,Shuilin Jin,Jiajie Peng, Renjie Tan, Tianjiao Zhang, Yu Li, Yadong Wang, LncRNA2Function: A comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data, BMC Genomics, 2015, 16:S2. Shuilin Jin, Renjie Tan, Qinghua Jiang, Li Xu, Jiajie Peng, Youg Wang andYadong Wang A generalized topological entropy for analyzing the complexity of DNA sequences, PLOS One 2014, 9(2): e88519. Li Xu,Shuilin Jin,Guisheng Yin, A track association algorithm based on the weighted association graph for laser triangulation sensors, Optik, 2014, 125(20): 5973-5977. Li Xu,Shuilin Jin,Guisheng Yin,A track association algorithm based on leader-follower on-line clustering in dense target environments, Radioengineering, 2014, 23(1):259-265. Li Xu, Shuilin Jin, Guisheng Yin,Bidirectional-paralleled flexible graphplan, Journal of Computational and Theoretical Nanoscience, 2014, 11(10):2190-2193. Shuilin Jin and Li Xu. Independences of operator algebras and joint spectrum of operators. Linear and Multilinear Algebra. 2013, 61(5): 565-572. Qinghua Jiang, Guohua Wang, Shuilin Jin, Yu Li, Yadong Wang Predicting human microRNA-disease associations based on support vector machine, International Journal of Data Mining and Bioinformatics. 2013, 8(3): 282-293. Shuilin Jin and Li Xu. On Curto’s open problem. Journal of Mathematical Analysis and Applications. 2013, 1(405): 342-344. Shuilin Jin, Li Xu and Qinghua Jiang. Joint spectrum and joint distribution. Complex Analysis and Operator Theory. 2013, 7: 1869-1875. Li Li, Shuilin Jin and Li Yang. Large time behavior of the Vlasov-Poisson-Boltzmann system. Abstract and Applied Analysis. 2013, 2013: 632903. Li Xu, Shuilin Jin and Guisheng Yin. Track fusion via track filter in dense sensor environments. Measurement. 2013, 46(10): 3871-3875. Shuilin Jin, Li Xu, Qinghua Jiang and Li Li. Conditions equivalent to C* independence Studia Mathematica. 2012, 211(3):191-197. Shuilin Jin and Li Xu. The entanglement of independent quantum systems. Advances in Mathematical Physics. 2012, 2012: 104856. Shuilin Jin, Qinghua Jiang, Yadong Wang and Guangren Duan. On joint spectrum of infinite direct sums. Operators and Matrices. 2012, 6(3): 529-533. Shuilin Jin, Li Xu, Qinghua Jiang and Guangren Duan. A joint spectral characterization of C* independence. Infinite Dimensional Analysis Quantum Probability and Related Topics. 2012, 15(2): 1250013.

学术兼职

现担任数学评论(Math Review)评论员,德国数学文摘(Zentralblatt Math)评论员,多个杂志通讯评审,自然科学基金通讯评审,教育部自然科学奖通讯评审,教育部学位论文通讯评审,中国高校创新创业教育研究中心专家等

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