个人简介
1999年毕业于山东大学获微生物学学士学位。2005年毕业于中国科学院上海生物化学与细胞生物学研究所,获细胞生物学博士学位。随后在美国伦斯勒理工大学从事博士后研究。2011年获得美国纽约州州立大学流行病与生物统计学院的生物统计硕士学位。2011-2013年在美国Wells Fargo & Co. 任数据分析师。2013年7月任中国科学技术大学生命科学学院特任副研究员。研究成果发表于Cancer Research,Nature Communications,Cell Research,Mol. Biol. Cell,Mol. Cell Biol.,Cell Discovery等期刊。
研究领域
细胞有丝分裂过程中的物质能量代谢调控;细胞分裂调控与抗肿瘤药物的作用机理;炎症与肿瘤的发展和治疗。
近期论文
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Yin T#, Zhao ZB#, Guo J#, Wang T, Yang JB, Wang C, Long J, Ma S, Huang Q, Zhang K, Ma X, Liu C, Liu S, Lian ZX*, Yang Z*. 2019. Aurora-A inhibition eliminates myeloid cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in breast cancer. Cancer Research. 2019 Mar 22.(#Co-first) Ma X, Wang L, Huang, Li Y, Yang D, Li T, Li F, Sun L, Wei H, He K, Yu F, Zhao D, Hu L, Xing S, Liu Z, Li K, Guo J, Yang Z, Pan X, Li A, Shi Y, Wang J, Gao P, Zhang H. 2017. Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway. Nat Commun. 8(1):1506. Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Van Dyke T, Wang F, Yao X, Guo J* and Yang Z* 2017. Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B Feedback Loop in late G2 phase. Cell Discovery 3, 16049 (*Co-corresponding). Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, Zhu X. Misfolded Gβ is recruited to cytoplasmic dynein by Nudel for efficient clearance. Cell Res. 22(7):1140-54. 2012. Guo J., YangZ., Song W., Chen Q., Wang F., Zhang Q. and Zhu X. Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. Mol Biol Cell. 17(2):680-689. 2006. Yang Z.§, Guo J.§, Chen Q., Du J., Ding C., and Zhu X. Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Mol. Cell. Biol. 25: 4062-4074. 2005. (§ Co-first author).