个人简介
2007年毕业于中国科学技术大学生命科学学院,获理学学士学位;2007年至2012年在中国科学技术大学生命科学学院硕博连读,2012年获中国科学技术大学理学博士学位;2012-2014年中国科学技术大学博士后,2014年5月聘为中国科学技术大学特任副研究员。期间获中国博士后科学基金面上项目、安徽省教育厅自然科学重点项目、安徽省科技厅自然科学基金面上项目、校青年基金等资助,目前从事新型表达系统、发酵工程和生物技术产品研究及产业化开发工作。目前已经发表SCI论文5篇,申请国家发明专利8项,已获授权4项。
研究领域
1) 治疗性重组蛋白;2)高密度发酵技术;3) 生物技术药物临床前研究;
近期论文
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1.Yugang Guo, Jing Wu, Hao Jia, Wei Chen, Changsheng Shao, Lei Zhao, Jiajia Ma, Rui Li, Yongjun Zhong, Fang Fang, Dong Wang, Jie Sun, Fang Qian, Xiangrong Dai, Guohui Zhang, Xiaoyi Li, Zhigang Tian, and Weihua Xiao,Balancing Production of Heterodimeric Protein: Recombinant Agkisacutacin as a Novel Antithrombotic Drug Candidate, Scientific Reports, 5, 11730, 2015. 2.Yugang Guo, Rui Li, Xiaoping Song, Yongjun Zhong , Chenguang Wang, Hao Jia, Lidan Wu, Dong Wang, Fang Fang, Jiajia Ma, Wenyao Kang, Jie Sun, Zhigang Tian, Weihua Xiao, The expression and characterization of functionally active soluble CD83 by Pichia pastoris using high-density fermentation, PLOS ONE 9(2): e89264,2014. 3.Yugang Guo, Gan Luan, Guodong Shen, Lidan Wu, Hao Jia, Yongjun Zhong, Rui Li, Guangwei Li, Yi Shen, Jie Sun, Siyi Hu, Weihua Xiao, Production and characterization of recombinant 9 and 15 kDa granulysin by fed-batch fermentation in Pichia pastoris. Appl Microbiol Biotechnol 97(17): 7669-7677,2013. 4.Yugang Guo, Wenyao Kang, Yongjun Zhong, Rui Li, Guangwei Li, Yi Shen, Siyi Hu, Jie Sun, Weihua Xiao, Purification and characterization of human IL-10/Fc fusion protein expressed in Pichia pastoris, Protein Expression and Purification 83 (2):152-6, 2012; 5.Yongjun Zhong, Lu Yang, Yugang Guo, Fang Fang, Dong Wang, Rui Li, Ming Jiang,Wenyao Kang, Jiajia Ma, Jie Sun, Weihua Xiao, High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10, Microbial Cell Factories, 13:163, 2014.