张隆华 - 中国科学技术大学

个人简介

2006年毕业于中国科学技术大学生命科学学院，获理学博士学位。其后赴美国马里兰大学医学院生理系从事博士后工作，研究内源性大麻素在生理和病理条件下起作用的神经机制。2011年2月作为中国科学技术大学优秀人才引进，现任生命科学学院副教授。主要研究成果发表于JNS，Plos One，PNAS，Neuropsychopharmacology等国际学术期刊。

研究领域

1，与心脏疾病相关的受体和离子通道蛋白（主要是钾离子通道）的结构与功能研究。2，综合应用分子生物学、电生理膜片钳技术阐述通道蛋白受调控（包括辅助亚基调控、天然毒素调控等）的结构与功能机制。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Pan Li, Haowen Liu, Chaohua Lai, Peibei Sun, Wenping Zeng, Fangming Wu, Longhua Zhang, Sheng Wang*, Changlin Tian*, Jiuping Ding*. Differential Modulations of KCNQ1 by Auxiliary Proteins KCNE1 and KCNE2. Sci Rep 2014;4: 4973 2.Man Pan, Yao He, Ming Wen, Fangming Wu, Demeng Sun, Sijian Li, Longhua Zhang*, Yiming Li*, Changlin Tian*. One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1. Chem Commun 2014;50(44): 5837-39 3.Mu Yu, Peibei Sun, Yao He, Liang Xiao, Demeng Sun, Longhua Zhang*, Changlin Tian*. Mutation of the critical pH-gating residues histidine 231 to glutamate increase open probability of outer membrane protein G in planar lipid bilayer. Protein Cell2013; 4(11): 803-6 4.Longhua Zhang, Meina Wang, Tiziana Bisogno, Vincenzo Di Marzo,Bradley E. Alger.Endocannabinoids generated by Ca2+ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipase. PLoS One 2011; 6(1):e16305. 5.Longhua Zhang, Bradley E. Alger.Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome. J Neurosci 2010; 30(16):5724-9. 6. David A. Edwards, Longhua Zhang, Bradley E. Alger. Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus. Proc Natl Acad Sci U S A 2008; 105(23): 8142-8147. 7. Longhua Zhang, Neng Gong, Da Fei, Lin Xu, Tian-Le Xu.Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology 2008; 33(3): 701-711. 8. Longhua Zhang, Lin Xu, Tian-Le Xu.Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats. Biochem Biophys Res Commun 2006; 344(3): 721-726.