高晓莲 - 中国科学技术大学

个人简介

高晓莲，兼职教授，博士生导师。1978-1982年在北京化工学院学习，获高分子科学学士学位；1982-1986年在Rutgers University, the State University of New Jersey读研究生，师从Roger A. Jones教授，研究内容为同位素标记的寡聚核糖核酸合成及NMR表征（Synthesis and NMR Characterization of Isotope Labeled Oligodeoxyribonucleotides），获化学博士学位； 1986-1989年在哥伦比亚大学医学院（Columbia University, Colleges of Physicians and Surgeons）从事博士后研究，师从Dinshaw Patel教授，研究方向为生物化学与生物物理，内容是DNA以及配基-DNA复合物的核磁共振（NMR of DNA and Ligand-DNA Complexes）；1990-1992年在葛兰素公司研究实验室（Glaxo Inc. Research Laboratories）任高级科学家和研究员，研究方向是结构生物学；1992-1998, 1998-2002, 2002-2004年在休斯敦大学历任化学助理教授、副教授、教授，同时兼生物学与生物化学助理教授、副教授、教授。2005至今任休斯敦大学生物学与生物化学教授，并兼化学与生物医学工程教授；2008年至今任中国科学技术大学兼职教授。

研究领域

主要研究兴趣是化学与生物学的交叉领域: 重点包括（1）高密度生物芯片上生物大分子的并行合成化学；（2）生物芯片在基因组学和蛋白质组学中的应用；（3）发展合成生物学方法；（4）核酸、蛋白质及其复合物结构测定的生物分子核磁共振波谱学，以及加快蛋白质核磁共振波谱阐释的数据库研究。

近期论文

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Zhou Q, Li M, Wang X, Li Q, Wang T, Zhu Q, Zhou X, Wang X, Gao X, Li X. (2012) , Immune-related microRNAs are abundant in breast milk exosomes. Internatinal J. Biol. Sci. 8(1):118-23. Li. M. Z., Liu, Y., Wang, T., Guan, J., Luo, Z. Chen, H., Chen, L., Zhou, S., Ma., J., Mu, Z., Jiang, A.-A, Lang, Q., Zhou, X., Wang, J., Zeng, W., Li, N., Gao, X. Li, X. (2011) , Repertoire of porcine microRNAs in adult ovary and testis by deep sequencing. International J. Biol. Sci. 7(7):1045-55. Li M, Xia Y, Gu Y, Zhang K, Lang Q, Chen L, Guan J, Luo Z, Chen H, Li Y, Li Q, Li X, Jiang AA, Shuai S, Wang J, Zhu Q, Zhou X, Gao X, Li X. (2010) MicroRNAome of porcine pre- and postnatal development. PLoS One. 5(7):e11541 Xia, Y., Yamaoka, Y., Zhu, Q., Matha, I., Gao, X. (2009) A Comprehensive sequence and disease correlation analyses for the C-terminal region of CagA protein of Helicobacter pylori. Plos Biology, 4, e7736. Gong, W., Zhou, D., Ren, Y., Wang, Y., Zuo, Z., Shen, Y., Xiao, F., Zhu, Q., Hong, A., Zhou, Z., Gao, X., and Li, T. (2008) PepCyber:P~PEP : A database of human protein-protein interactions mediated by phosphoprotein binding domains. Nucleic Acids Res. 36, D679-D683. Gu, P., Reid, J., Gao, X., Shaw, C. A., Creighton, C., Dugas, D. T., Tran, P. L., Zhou, X., Drabek, R., Steffen, D. L., Hoang, D., Weiss, M. K., Naghavil, A. O., El-daye, J., Kahn, M. F., Legge, G. B., Wheeler, D., Gibbs, R. A., Miller, J., Cooney, A. J., and Gunaratne, P. H. (2008) Novel microRNA candidates and miRNA-mRNA pairs in embryonic stem (ES) cells. Plos ONE. 3, e2578. He, P. A., Nie, Z., Chen, J., Chen, J., Lv, Z., Sheng, Q., Zhou, S., Gao, X., Kong, L., Wu, X., Jin, Y. and Zhang, Y. (2008) Identification and characteristics of microRNAs from Bombyx mori. BMC Genomics 9, 248. Xiao, F., Zuo, Z., Cai, G., Kang, S., Gao, X. and Li, T. (2008) miRecords: an integrated resource for microRNA-target interactions. Nucleic Acids Res. Wan, J., Kang, S., Tang, C., Yan, J., Ren, Y., Liu, J., Gao, X., Banerjee, A., Ellis, L. B. M., and Li, T. (2007) Meta-prediction of phosphorylation sites with weighted voting and restricted grid search parameter selection. Nucleic Acids Res. In press. Feng, J., Wong, K.-Y., Lynch, G. C., Gao, X., and Pettitt, B. M. (2007) Peptide conformations of a microarray surface-tethered epitope of the tumor suppressor p53. J. Physical Chem. 111, 13797-13806. Anbanandam, A., Albarado, D. C., Nguyen, C. T., Gao, X., Halder, G., Veeraraghavan, S. (2006) Insights into TEF-1 activity from the solution structure of TEA domain. Proc. Natl. Acad. Sci. USA, 103, 17225-17230. Stahler, P, Beier, M, Gao, X, Hoheisel, J. (2006) Another side of genomics: Synthetic biology as a means for the exploitation of whole-genome sequence information. J. Biotech. 124, 206-212. Backer, S. C. et al. (2005) The External RNA controls consortium: a progress report. Nature Methods 2, 731-734. Mulder, B. A., Anava, S., Yu, Pl, Lee, K. W., Nguyen, A., Murphy, J., Willson, R., Briggs, J. M., Gao, X., and Hardin, S. (2005) Nucleotide modification at the ?-phosphate leads to the improved fidelity of HIV-1 reverse transcriptase. Nucleic Acids Res. 33, 4865-4873. Rouillard, J. M., Lee, W. Truan, G., Gao, X., Zhou, X. and Gulari, E. (2004) Gene2Oligo: Oligonucleotide design for in vitro gene synthesis. Nucleic Acids Res. 32, W176-180. Li, C., Xia, Y., Gao, X., and Gershon, P. D. (2004) Mechanism of RNA 2'-O-methylation: Evidence that the catalytic lysine acts to steer rather than deprotonate the target nucleophile. Biochemistry 43, 5680-5687. Zhou, X., Cai, S., Hong, A., Yu, P., Sheng, N., Srivannavit, O., Yong, Q., Muranjan, S., Rouilard, J. M., Xia, Y., Zhang, X., Xiang, Q., Ganesh, R., Zhu, Q., Matejko, A., Gulari, E., and Gao, X. (2004) Microfluidic picoarray synthesis of oligodeoxynucleotides and simultaneously assembling of multiple DNA sequences. Nucleic Acids Res. 32, 5409-5417. Tian, J., Gong, H., Sheng, N., Zhou, X., Gulari, E., Gao, X., and Church, G. (2004) Accurate multiplex gene synthesis from programmable DNA chips. Nature 432, 1050-1054. Pellois, J. P., Zhou, X., Srivannavit, O., Zhou, T., Erdogan, G., and Gao, X. (2002) Individually addressable parallel peptide synthesis on microchips. Nat. Biotechnol. 20, 922-926.