单革 - 中国科学技术大学

个人简介

单革：教授，博导，国家杰出青年基金获得者。1995年兰州大学细胞生物学学士，1998中科院上海细胞所硕士，2004年美国佐治亚州立大学博士。先后在美国爱默蕾(Emory)大学和耶鲁大学（导师Sidney Altman, RNA酶的发现人之一、1989诺贝尔化学奖）进行博士后研究。2010年进入中国科学技术大学工作。单革博士长期从事基因表达调控和非编码RNA功能及功能机理方面的研究。实验室成立以来，发现了新的非编码RNA类型（EIciRNA、5S-OT、ASAT siRNA、tiny RNA、p53点突变适配体RNA）、研究了新的非编码RNA功能、揭示了新的非编码RNA作用机理、探索了新的非编码RNA研究方法。实验室成立以来在Developmental Cell (2017)，Nature Structural & Molecular Biology（2015, Highlighted in Nature reviews Molecular Cell Biology 及 Science Editors’ Choice），Nature Structural & Molecular Biology（2016, News and views in NSMB，入选Nature mRNA splicing 40 years on collection），Nature Communications（2012, Highlighted in Nature reviews Genetics 及 Nature reviews Microbiology），和P.N.A.S（2015, Direct submission）等期刊发表多篇研究论文。教育部“新世纪人才”（2010），中科院优秀研究生导师（2016），科技部“中青年科技创新领军人才”（2016），基金委“国家杰出青年基金”（2017）。

研究领域

1）环境对动物基因表达的调控（通过非编码RNA） 2）非编码RNA（如环形RNA、反义RNA在动物细胞中的调控与功能） 3）转录及转录后调控在模式动物（秀丽线虫及小鼠）神经发育中的功能

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Bin Yu, Xiaolin Wang, Shuai Wei, Tao Fu, Emmanuel Enoch Dzakah, Ahmed Waqas, Walter W. Walthall,Ge Shan#. Convergent transcriptional programs regulate cAMP levels in C. elegans GABAergic motor neurons. Developmental Cell, 2017, 43(2): 212-226. 2. Hu S*, Wang X*, Shan G#. Insertion of an Alu element in an lncRNA leads to primate specific modulation of alternative splicing. Nat Struct Mol Biol. 2016; 23(11):1011-1019. 3. Waqas A, Shan G#. Uptake and Reaction of C. elegans to Environmental RNAs. Non-coding RNAs and Inter-kingdom Communication. Springer International Publishing, 2016; pp117-124. 4. Rashid F, Shah A, Shan G#. Long Non-coding RNAs in the Cytoplasm. Genomics, Proteomics & Bioinformatics. 2016; 14(2):73-80. 5. Yu B, Shan G#. Functions of long noncoding RNAs in the nucleus. Nucleus. 2016; 7(2):155-66. 6. Hu S, Shan G#. LncRNAs in stem cells. Stem Cells Int. 2016; 2016:2681925. 7. Chuan Huang, Xiaolin Wang, Xu Liu, Shuhuan Cao, Ge Shan#. RNAi pathway participates into chromosome segregation in mammalian cells. Cell Discovery 2015, 1(1): 15029. 8. Zhaoyong Li*, Chuan Huang*, Chun Bao*, Liang Chen, Mei Lin, Xiaolin Wang, Guolin Zhong, Bin Yu, Wanchen Hu, Limin Dai, Pengfei Zhu, Zhaoxia Chang, Qingfa Wu, Yi Zhao, Ya Jia, Ping Xu, Huijie Liu, Ge Shan#. Exon-Intron circular RNAs regulate transcription in the nucleus. Nat. Struct. Mol. Bio. 2015, 22(3):256-264. 9. Liu H*, Wang X*, Wang HD, Wu J, Ren J, Meng L, Wu Q, Dong H, Wu J, Kao TY, Ge Q, Wu ZX, Yuh CH, Shan G#. Escherichia coli noncoding RNAs can affect gene expression and physiology of Caenorhabditis elegans. Nature Communications, 2012, 25 (3): 1073. 10. Hu S, Wu J, Chen L, Shan G#. Signals from noncoding RNAs: Unconventional roles for conventional pol III transcripts. The International Journal of Biochemistry & Cell Biology, 2012; 44(11): 1847-51. 11. Ge Shan#. RNA interference as gene knockdown technique. The International Journal of Biochemistry & Cell Biology 2010, 42(8):1243-51. 12. Luo Y*, Shan G*, Guo W*, Smrt RD, Johnson EB, Li X, Pfeiffer RL, Szulwach KE, Duan R, Barkho BZ, Li W, Liu C, Jin P, Zhao X. Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells. PLOS Genetics 2010, 6(4): e1000898. 13. G. Shan, Y. Li, Zhang J, Li W, Szulwach KE, Duan R, Faghihi MA, Khalil AM, Lu L, Paroo Z, Chan AW, Shi Z, Liu Q, Wahlestedt C, He C, Jin P. A small molecule enhances RNA interference and promotes the biogenesis of microRNAs. Nature Biotechnology. 2008, 26(8):933-40. 14. G. Shan, Walthall WW. Copulation in Caenorhabditis elegans requires a Nuclear Hormone Receptor. Developmental Biology. 2008, 322(1):11-20. 15. Shan G, Kim K, Li C, Walthall WW. Convergent genetic programs regulate similarities and differences between related motor neuron classes in Caenorhabditis elegans. Developmental Biology. 2005, 280(2):494-503.