光寿红 - 中国科学技术大学

个人简介

中国科学技术大学教授，博士生导师，新创-凯杰讲席教授。1996年在中国科学技术大学生物系获得学士学位。1996-1999年师从中国科大施蕴渝院士进行多肽的溶液构象研究，并获得硕士学位。1999-2004年，在美国威斯康星大学癌症研究所师从Janet Mertz教授，研究真核生物中病毒起源的无内含子RNA的表达和调控机制，并获得博士学位。2005-2010年，作为博士后在威斯康星大学遗传系Scott Kennedy教授实验室，从事模式生物中小干扰RNA的功能和调控机理的研究。2010年,加入生命科学院，进一步研究非编码RNA的功能和调控机制。以第一和通讯作者在包括《Nature》和《Science》在内的国际著名期刊上发表论文。

研究领域

（1）真核细胞中RNA的表达与加工的调节；（2）真核生物中转录调节机制；（3）非编码RNA的表达与调节机制；（4）模式生物的遗传与发育；(5) 基因编辑和染色体操纵的新技术和新方法。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Xufei Zhou, Xuezhu Feng, Hui Mao, Mu Li, Fei Xu, Kai Hu, and Shouhong Guang (2017) RdRP-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway. Nature Structural & Molecular Biology 2017 Feb 6. doi: 10.1038/nsmb.3376. 2. Chen X, Li M, Feng X, Shouhong Guang (2015) Targeted Chromosomal Translocations and Essential Gene Knockout Using CRISPR/Cas9 Technology in Caenorhabditis elegans. Genetics 2015 Dec;201(4):1295-306 doi: 10.1534/genetics.115.181883. 3. Hui Mao, Chengming Zhu, Dandan Zong, Chenchun Weng, Xiangwei Yang, Hui Huang, Dun Liu, Xuezhu Feng, and Shouhong Guang (2015) The Nrde pathway mediates small RNA-directed histone H3 lysine 27 trimethylation in Caenorhabditis elegans. Current Biology 2015 Sep 21;25(18):2398-403. 4. Xiangyang Chen, Fei Xu, Chengming Zhu, Jiaojiao Ji, Xufei Zhou, Xuezhu Feng, and Shouhong Guang (2014) Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans. Scientific Reports 2014 Dec. 22;4:7581. 5. Zhou X, Xu F, Mao H, Ji J, Meng Y, Feng X, and Shouhong Guang (2014) Nuclear RNAi Contributes to the Silencing of Off-Target Genes and Repetitive Sequences in Caenorhabditis elegans. Genetics 2014 May;197(1):121-32. 6. Sam Guoping Gu, Julia Pak, Shouhong Guang, Jay M. Maniar, Scott Kennedy, and Andrew Fire, (2012) Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint. Nature Genetics 2012，44:157-164. 7. Burkhart, K.B., Guang, S., Bochner, A.F., and Kennedy, S., (2011) A pre-mRNA–associating factor links endogenous siRNAs to chromatin regulation. PLoS Genetics 2011 Aug;7(8):e1002249. 8. Guang, S., Bochner, A.F., Pavelec, D.M., Burkhart, K.B., Burton, N., and Kennedy, S., (2010) Small regulatory RNAs inhibit RNA Polymerase II during the elongation phase of transcription. Nature, 2010，465:1097-1101.　　 9. Guang, S., Bochner, A.F., Pavelec, D.M., Burkhart, K.B., Harding, S., Lachowiec, J., and Kennedy, S., (2008) An Argonaute transports siRNAs from the cytoplasm to the nucleus. Science 321:537-541 Research Article　　　 10. Guang, S., Felthauser, A., and Mertz, J. (2005) Binding of hnRNP L to the pre-mRNA processing enhancer (PPE) of herpes simplex virus’ thymidine kinase gene enhances both polyadenylation and nucleocytoplasmic export of intronless mRNAs. Mol. Cell. Biol. 25:6303-6313. 11. Guang, S. and Mertz, J.E. (2005) PPE-like elements from intronless genes play additional roles in mRNA biogenesis than do ones from intron-containing genes. Nucleic Acid Res. 33(7):2215-2226.