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个人简介

11/2017 – 现在: 中国科学技术大学附属第一医院外科学教授 07/2007 - 09/2017: 德国汉堡大学肝胆外科及移植中心主任,外科学教授 11/2003 - 07/2007: 加拿大达尔豪斯大学伊丽莎白女王二世健康科学中心器官移植科主任,免疫、微生物学及外科学教授 04/1994 – 10/2003: 德国汉诺威大学附属医院器官移植及内脏外科高级医师 04/1988 – 03/1994: 德国汉诺威大学附属医院心脏、胸、血管外科,急诊科,腹部外科及器官移植中心住院医师 02/1986 – 03/1988: 汉诺威大学附属医院腹部外科住院医师及器官移植中心移植免疫实验室研究员

研究领域

移植免疫学,肿瘤生物学的分子信号研究,临床研究

近期论文

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1. Nashan B, Schlitt H J, Tusch G, Oldhafer K, Ringe B, Wagner S, Pichlmayr R. Biliarymalignancies in primary sclerosing cholangitis. Timing for liver transplantation. Hepatology 1996. 23:1105-11 2. Nashan B, Schlitt H J, Schwinzer R, Ringe B, Kuse E, Tusch G, Wonigeit K, Pichlmayr R.Immunoprophylaxis with a monoclonal anti IL-2 receptor antibody in liver transplantedpatients. Transplantation 1996; 61:546-54 3. Nashan B, Moore R, Amlot P, A G Schmidt, K Abeywickrama, J P Soulillou. Randomisedtrial of basiliximab versus placebo for control of acute cellular rejection in renal allograftrecipients. The Lancet 1997; 350:1193-8. 4. Nashan B, Light S, Hardie IR, Lin A, Johnson R. Reduction of acute renal allograft rejection by daclizumab. Transplantation 1999; 67:110-5. 5. Neipp M, G Offner G, R Lück R, Ehrich JHH, Strehlau J, Schlitt H J, Klempnauer J, Nashan B. Kidney transplantation in small children: Donor selection and technical consideration. Transplantation. 2002; 73: 409-16. 6. Nashan B, Curtis J, Ponticelli C, Mourad G, Jaffe J, Haas T on behalf of the 156 StudyGroup. Everolimus in Combination with Reduced-Exposure Cyclosporine in de novo RenalTransplant. Recipients: Results of a 3-Year Phase II, Randomized, Multicenter, Open- Label Study. Transplantation 2004; Nov 15;78(9):1332-40. 7. Neipp M, Jackobs S, Becjer T, Lueck R, Meyer zu Vilsendorf A, Winny M, Klempnauer J, Nashan B. Living Donor Nephrectomy: Flank Incision vs. Anterior Vertical Mini-Incision. Transplantation 2004; 15;78(9):1356-61. 8. Vincenti F, Larsen C, Durrbach A, Wekerle T, Nashan B, Blancho G, Lan P, Grinyo J, Halloran P F, Solez K, Hagerty D, Levy E, Zhou W, Natarajan K, Charpentier B; BelataceptStudy Group. Costimulation blockade with belatacept in renal transplantation. N Engl J Med. 2005; 353:770-81. 9. Frericks BB, Kirchhoff TD, Shin H O, Stamm G, Merkesdal S, Abe T, Schenk A, Peitgen HO, Klempnauer J, Galanski M, Nashan B. Preoperative volume calculation of the hepaticvenous draining areas with multi-detector row CT in adult living donor liver transplantation: impact on surgical procedure. Eur Radiol. 2004 Feb;14(2):326-33. 10. Ekberg H, Tedesco-Silva H, Demirbas A, Vítko S, Nashan B, Gürkan A, Margreiter R, Hugo C, Grinyó JM, Frei U, Vanrenterghem Y, Daloze P, Halloran; ELITE-Symphony Study. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med. 2007 Dec 20;357(25):2562-75. 11. Nashan B, Saliba F, Durand F, Barcéna R, Herrero J I, Mentha G, Neuhaus P, Bowles M, Patch D, Bernardos A, Klempnauer J, Bouw R, Ives, R J Mamelok, D Mc Kay, M Truman, P Marotta. Pharmacokinetics, efficacy, and safety of mycophenolate mofetil in combination with standard-dose or reduced-dose tacrolimus in liver transplant recipients. Liver Transpl. 2009 Feb;15(2):136-47. 12. Vincenti F, Blancho G, Durrbach A, Friend P, Grinyo J, Halloran P F, Klempnauer J, Lang P, Larsen C P, Mühlbacher F, Nashan B, Soulillou J P, Vanrenterghem Y, Wekerle T, Agarwal M, Gujrathi v, Shen J, R Shi R, Townsend R, Charpentier B. Five-year safety and efficacy of belatacept in renal transplantation. J Am Soc Nephrol. 2010. Sep;21(9):1587-96. PMID:20634298 13. Friman S, Arns W, Nashan B, Vincenti F, Banas B, Budde K, Cibrik D, Chan L, Klempnauer J, Mulgaonkar S, Nicholson M, Wahlberg J, Wissing KM, Abrams K, Witte S, Woodle ES. Sotrastaurin, a novel small molecule inhibiting protein-kinase C: randomized phase II study in renal transplant recipients. Am J Transplant. 2011 Jul;11(7):1444-55. 14. Grabinski N, Ewald F, Hofmann BT, Staufer K, Schumacher U, Nashan B, Jücker M. Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells. Mol Cancer. 2012 Nov 20;11:85. 15. Ewald F, Grabinski N, Grottke A, Windhorst S, Nörz D, Carstensen L, Staufer K, Hofmann BT, Diehl F, David K, Schumacher U, Nashan B, Jücker M. Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma. Int J Cancer. 2013 Apr 16. 16. David KA, Unger FT, Uhlig P, Juhl H, Moore HM, Compton C, Nashan B, Dörner A, de Weerth A, Zornig C. Surgical procedures and postsurgical tissue processing significantly affect expression of genes and EGFR-pathway proteins in colorectal cancer tissue. Oncotarget. 2014 Nov 30;5(22):11017-28. doi: 10.18632/oncotarget.2669. 17. Ewald F, Nörz D, Grottke A, Hofmann BT, Nashan B, Jücker, M. Dual Inhibition of PI3K- AKT-mTOR- and RAF-MEK-ERK-signalling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors. Invest New Drugs. 2014 Dec;32(6):1144- 54. doi: 10.1007/s10637-014-0149-7. 18. Nörz D, Grottke A, Bach J, Herzberger C, Hofmann BT, Nashan B, Jücker M, Ewald F. Discontinuing MEK inhibitors in tumor cells with an acquired resistance increases migration and invasion. Cell Signal. 2015 Jul 22. pii: S0898-6568(15)00213-2. doi:10.1016/j.cellsig.2015.07.016. 19. Stein A, Arnold D, Bridgewater J, Goldstein D, Jensen LH, Klümpen HJ, Lohse AW, Nashan B, Primrose J, Schrum S, Shannon J, Vettorazzi E, Wege H. Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial) - arandomized, multidisciplinary, multinational phase III trial. BMC Cancer. 2015 Jul 31;15:564. doi: 10.1186/s12885-015-1498-0.

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