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个人简介

朱 书,男,1984年出生,博士,中国科学技术大学生命科学学院教授、博士生导师;入选微尺度国家研究中心以及中科院分子细胞卓越中心(2017);科技部重大研发计划青年项目首席科学家(2018),基金委优秀青年基金获得者(2018)。教育和研究经历: 2002-2006年,中国科学技术大学生命科学学院,获学士学位 2006-2012年,上海生命科学研究院健康科学研究所,获细胞生物学博士学位 2012-2017年,美国耶鲁大学医学院免疫学系,博士后 2017年 至今,中国科学技术大学生命科学学院,教授博导

研究领域

肠道作为人体最大的粘膜免疫器官,聚集了远超过人体细胞数目的微生物和全身一半以上的免疫细胞。我们之前的工作发现肠道先天免疫系统(NLRs)如何识别病原微生物(Zhu, Ding et al.,Nature, 2017; Wang, Zhu et al.,Science, 2016), 同时发现肠道辅助型T细胞及其分泌的细胞因子如何介导针对肠道微生物的免疫反应

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

35. H Ma*, W Tao*, and S Zhu#. 2019. T Lymphocytes in Intestinal Mucosa: Defense and Tolerance. Cell Mol Immunol. Accepted. (#co-corresponding author; Invited review) (IF=8) 34. J Wang, MF. Sanmamed, I Datar, T Su, L Ji, J Sun, L Chen, Y Chen, G Zhu, L Zheng, T Zhou, T Badri, S Yao, S Zhu, A Boto, M Sznol, I Melero, DA. Vignali, K Schalper and L Chen#. 2018. Fibrinogen-like protein 1 is a major ligand of LAG-3 for T-cell suppression and the evasion of tumor immunity. Cell. 176, 1–14.doi:org/10.1016/j.cell.2018.11.010. (IF=32) 33. LYang*, S Zhu, P Wang# et al. 2019. The STING-MSR1 Axis Controls RNA Virus Infection Through Noncanonical Autophagy. SSRN Electronic Journal. 32. S Ding, S Zhu, L Ren, N Feng, X Ge, B Li, RA Flavell, HB Greenberg#. 2018. Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells. Elife. 2018 Nov 21;7. pii: e39494. doi: 10.7554/eLife.39494.(IF=8) 31. L Wu, J Cao, WL Cai, SM Lang, JR Horton, DJ Jansen, ZZ Liu, JF Chen, M Zhang, BT Mott, K Pohida, G Rai, SC Kales, MJ Henderson, X Hu, A Jadhav, DJ Maloney, A Simeonov, S Zhu, A Iwasaki, MD Hall, X Cheng, GS. Shadel, Q Yan#. 2018. KDM5 histone demethylases repress immune response via suppression of STING. Plos Biology. 2018 Aug 6;16(8):e2006134. doi: 10.1371/journal.pbio.2006134. (IF=9) 30. J Tong, G Cao, T Zhang, E Sefik, M Amezcua Vesely, J Broughton, S Zhu, H Li, B Li, Lei Chen, H Chang, B Su, R Flavell# & HB Li#. 2018. m6A mRNA methylation sustains Treg suppressive functions. Cell Research. doi:10.1038/cr.2018.7(IF=15) 29. Zhu S*, Ding S*, Wang P, Wang G, Lei X, Palm N, Pan W, Zheng Y, Feng N, Lu J, Shan L, Abraham C, Fikrig E, Greenberg H#, Flavell R#. Nlrp9b recognizes and restricts rotavirus infection in intestinal epithelial cells. 2017. Nature. doi:10.1038/nature22967. (Comment in Nature, doi:10.1038/nature23090, Research highlight in Cell Research, doi: 10.1038/cr.2017.93, Evaluated by Faculty of 1000 Biology, *co-first author). (IF=42) 28. Li, H.*, J. Tong*, S. Zhu*, P. Batista, J.Zhao, W. Bailis, Y. Yang, G. Wang, Y. Chen, Y. Kluger, Howard Y. Chang, Zhinan Yin#, Richard A. Flavell#. 2017. m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway. Nature. doi:10.1038/nature23450. (*co-first author) (IF=42) 27. Pan W, Zhu S, K Qu, K Meeth, J Cheng, K He, H Ma, Y Liao, X Wen, C Roden, Z Tobiasova, Z Wei, J Zhao, J Liu, J Zheng, B Guo, M Bosenberg, R Flavell, J Lu#. 2017. Tet2 sustains the immunosuppressive function of myeloid cells and promotes melanoma growth. Immunity. 2017, doi: 10.1016/j.immuni.2017.07.020.(IF=24) 26. Yu H, Borsotti C, Schickel JN, Zhu S, Strowig T, Eynon EE, Frleta D, Gurer C, Murphy AJ, Yancopoulos GD, Meffre E, Manz MG, Flavell RA#. 2017. A novel humanized mouse model with significant improvement of class- switched, antigen-specific antibody production. Blood. doi: 10.1182/blood-2016-04-709584.(IF=12) 25. H Yu, N Gagliani, H Ishigame, S Huber, S Zhu, E Esplugues, K Herold, L Wen, R Flavell#. 2017. Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development. Proceedings of the National Academy of Sciences, doi: 10.1073/pnas.1705599114. (IF=10) 24. Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA#. 2016. The DNA Sensing Aim2 Inflammasome Controls Radiation Induced Cell death and Tissue Injury. Science. 2016 Nov 11;354(6313):765-768. (IF=41) 23. Shu Zhu, Geng Wang, Xuqiu Lei, Richard A. Flavell#. 2016. Mex3B, a coreceptor to present dsRNA to TLR3. Cell Research. 26(4):391-2. doi: 10.1038/cr.2016.29. (IF=15)

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