张华凤 - 中国科学技术大学 - 合肥微尺度物质科学国家研究中心

个人简介

Dr. Huafeng Zhang obtained Ph. D degree from University of Tokyo in Japan in 2004. She went on for her postdoctoral study in National Cancer Institute of NIH from 2004 to 2005, studying protein dynamics. From 2005 to 2010, she worked in the laboratory of Dr. Gregg Semenza in Johns Hopkins University to study hypoxia and cancer development. Her major achievements include multiple highly-cited papers in the field of cancer research. She has published more than 60 research papers that are cited more than 7000 times by peer scientists. She has been a professor in School of Life Sciences USTC. She is also joint-appointed as a faculty member at Division of Molecular Medicine, Hefei National Laboratory for Physical Science at Microscale.

研究领域

1. Tumor microenvironment and metabolism 2. Tumor microenvironment and metastasis 3. Epigenetic changes in tumor development 4. Developing new anti-cancer therapies

近期论文

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1. Li ST, Huang D, Shen S, Cai Y, Xing S, Wu G, Jiang Z, Hao Y, Yuan M, Wang N, Zhu L, Yan R, Yang D, Wang L, Liu Z, Hu X, Zhou R, Qu K, Li A, Duan X*, Zhang H*, Gao P*. Nature Metabolism, 2020 March. 2. Xing S, Li Z, Ma W, He X, Shen S, Wei H, Li ST, Shu Y, Sun L, Zhong X, Huangfu Y, Su L, Feng J, Zhang X, Gao P, Jia WD*, Zhang H*. DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing. Cancer Res. 2019 Oct 1;79(19):4923-4936. 3. Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W*, Zhang H*. Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1. EMBO Rep. 2019 Oct 4;20(10):e48115. doi: 10.15252/embr.201948115. 4. Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H*, Zhou Q*, Gao P*. Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells. Cell Metabolism 2019 Apr 2;29(4):979-992 (IF: 20.57). 5. Xiaoyu Ma, Lin Wang, De Huang, Yunyan Li, Dongdong Yang, Junfeng Wang*, Ping Gao* and Zhang H*. Polo-like Kinase 1 Coordinates Biosynthesis during Cell Cycle Progression by Directly activating. Pentose phosphate pathway. Nature Communications 2017 Nov 15;8(1):1506 (IF: 12.35). 6. Huang D#, Li T#, Wang L, Zhang L, Yan R, Kui Li, Xing S, Wu G, Hu L, Jia W, Lin S, Dang CV, Song L*, Gao P*, Zhang H*. Hepatocellular carcinoma redirects to ketolysis for progression under nutrition stress. Cell Research 2016 Sep 20. 26(10), 1112-1130 (IF: 15.39). 7. Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Wang Y, Gao P*, Tang H*, Zhang H*. cMyc-Mediated Activation of Serine Biosynthesis Pathway is Critical for Cancer Progression under Nutrient Deprivation Conditions. Cell Research 2015 Apr;25(4):429-44 (IF: 15.39). 8. Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P and Zhang H*. HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation is Critical for Cancer Progression. Cell Reports 2014 Sep 25;8(6):1930-42. 9. Ma X, Li C, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P*, Zhang H*. Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nature Communications. 2014 Oct 10;5:5212. 10. Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Dang CV, Semenza GL*. HIF-1 represses mitochondrial mass and respiration in VHL-null renal cell carcinoma. Cancer Cell 11(5):407-20,2007 (IF: 22.84).