个人简介

EDUCATION AND RESEARCH EXPERIENCE 1993.08-1996.07 M.s., Immunology, Shandong Academy of Medical Sciences 2000.08-2003.07 Ph. D., Immunology, Shandong University 1996.07-2001.09 Assistant Professor and Associate Professor of Shandong Cancer Biotherapy Center, Institute of Basic Medical Sciences, Shandong Academy of Medical Sciences 2001.09-2005.12 Associate Professor of School of Life Sciences, USTC 2005.12-2014.12 Professor of School of Life Sciences, USTC 2015.01-present Professor & Vice-Dean of School of Life Sciences, USTC

研究领域

1. Innate immunity and immune diseases 2. Tumor immunity and tumor biotherapy 3. Recognition and differentiation of NK cells

CURRENT RESEARCH PROJECTS 1. The effect of immunity on gametogenesis and embryonic development, 2018.12-2021.12, supported by National Key Research & Developmental Program of China 2. NK cells regulation of immune tolerance and immune rejection at the maternal-fetal microenvironment, 2020.1-2024.12, supported by the Natural Science Foundation of China

近期论文

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Zhou Y, Fu B*, Xu X, Zhang J, Tong X, Wang Y, Dong Z, Zhang X, Shen N, Zhai Y, Kong X, Sun R, Tian Z*, Wei H*. PBX1 expression in uterine natural killer cells drives fetal growth. Sci Transl Med. 2020 Apr 1;12(537):eaax1798. Cong J, Wang X, Zheng X, Wang D , Fu B, Sun R, Tian Z*, Wei H*. Dysfunction of Natural Killer Cells by FBP1-induced Inhibition of Glycolysis during Lung Cancer Progression. Cell Metabolism. 2018 Aug 7;28(2):243-255. Zheng X, Qian Y, Fu B, Jiao D, Jiang Y, Chen P, Shen Y, Zhang H, Sun R, Tian Z*, Wei H*. Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance. Nat Immunol. 2019 Dec; 20(12):1656-1667. Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z*, Wei H*. Natural killer cells promote fetal development through the secretion of growth-promoting factors. Immunity. 2017 Dec 19;47(6):1100-1113. Zheng X, Fan X, Fu B, Zheng M, Zhang A, Zhong K, Yan J, Sun R, Tian Z*, Wei H*. EpCAM inhibition sensitizes chemoresistant leukemia to immune surveillance. Cancer Res. 2017 Jan 15;77(2):482-493. Zheng X, Cheng M, Fu B, Fan X, Wang Q, Yu X, Sun R, Tian Z*, Wei H*. Targeting LUNX Inhibits Non-Small Cell Lung Cancer Growth and Metastasis. Cancer Res. 2015 Mar 15;75(6):1080-90. Lv S, Wang J, Dou S, Yang X, Ni X, Sun R, Tian Z*, Wei H*. Nanoparticles encapsulating HBV-CpG induce therapeutic immunity against hepatitis B virus infection. Hepatology. 2014 Feb 59(2):385-94. Fu B, Li X, Sun R, Tong X, Ling B, Tian Z*, Wei H*. Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):E231-40. Ni F, Sun R, Fu B, Wang F, Guo C, Tian Z*, Wei H*. IGF-1 promotes the development and cytotoxic activity of human NK cells. Nat Commun. 2013 Feb 12; 4:1479.