个人简介
03/1978-12/1982 M.D., Shanxi Medical University, China
03/1983-08/1985 M.S., Immunol, Shandong Acad Med Sci, China
03/1986-03/1989 Ph.D., Immunology, Normal Bethune Med Univ, China
04/1989-12/2001 Assist/Asso/Full Professor, Shandong Acad Med Sci
08/1994-06/1996 Visiting Scientist, NCI, NIH, USA
02/1999-08/1999 Visiting Professor, Med College Virginia, Richmond
08/2000-12/2000 Visiting Scientist, NCI, NIH, USA
01/2001-present Professor, Univ Sci Tech China, China
01/2002-04/2002 Visiting Scientist, NIAAA, NIH, USA
05/2002-04/2003 Visiting Professor, Kanazawa Univ Cancer Inst, Japan
研究领域
1. NK cell subsets and differentiation
2. NK cell-based immunotherapy of cancer
3. Liver immune tolerance and diseases
近期论文
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Zong L, Peng H , Sun C, Li F, Zheng M, Chen Y, Wei H, Sun R, Tian Z*. Breakdown of adaptiveimmunotolerance induces hepatocellular carcinoma in HBsAg-tg mice. Nat Commun. 2019 Jan; 10(1):221.
Zhou J, Peng H*, Li K, Qu K, Wang B, Wu Y, Ye L, Dong Z, Wei H, Sun R, Tian Z*. Liver-resident NK cells control antiviral activity of hepatic T cells via PD-1/PD-L1 axis. Immunity. 2019 Feb; 50(2):403-417.
Wang X, Sun R, Hao X, Lian Z, Wei H, Tian Z*. IL-17 constrains natural killer cell activity by restraining IL-15-driven cell maturation via SOCS3. PNAS 2019; 116:17409-17418.
Wang X, Peng H*, Cong J, Wang X, Lian Z, Wei H, Sun R*, Tian Z*. Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis. Nat Commun. 2018 Nov; 9(1):4854.
Cong J, Wang X, Zheng X, Wang D, Fu B, Sun R, Tian Z*, Wei H*. Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression. Cell Metab. 2018 Aug; 28(2):243-255.
Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, Wang Z, Wu Q, Peng H, Wei H, Sun R*, Tian Z*. Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat Immunol. 2018 Jul; 19(7):723-732.
Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G , Song J, Wang J, Wei H, Zhang J, Sun R, Zhang C*, Tian Z*. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nat Commun. 2018 Mar; 9(1):1241.
Fu B, Zhou Y，Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z*, Wei H*. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors. Immunity. 2017 Dec; 47:1100-1113.
Li F, Hao X, Chen Y, Bai L, Gao X, Lian Z, Wei H, Sun R, Tian Z*. Microbiota maintains homeostasis of liver-resident γδT-17 cells in a lipid antigen-CD1d–dependent manner. Nat Commun. 2017 Jan; 7:13839.
Yu X, Lan P, Hou X, Han Q, Lu N, Li T, Jiao C, Zhang J, Zhang C*, Tian Z*. HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production. J Hepatol. 2017 Apr; 66(4):693-702.
Chen S, Yang M, Du J, Li D, Li Z, Cai C, Ma Y, Zhang L, Tian Z*, Dong Z*. The Self-Specific Activation Receptor SLAM Family Is Critical for NK Cell Education. Immunity. 2016 Aug; 45(2):292-304.
Zeng Z, Li L, Chen YY, Wei HM, Sun R, Tian Z*. Interferon-γ facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance. J Exp Med. 2016 May; 213(6):1079-93.
Wu X, Sun R, Chen Y, Zheng X, Bai L, Lian Z, Wei H, Tian Z*. Oral ampicillin inhibits liver regeneration by breaking hepatic innate immune tolerance normally maintained by gut commensal bacteria. Hepatology. 2015 Jul; 62(1):253-64.
Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R*, Tian Z*. Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice. J Hepatol. 2015 Jun; 62(6):1311-8.
Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z*, Zhou R*. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell. 2015 Jan; 160(1-2):62-73.
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