个人简介

教育背景 美国Michigan State University微生物学博士 任职经历 2004年至今，中国科学技术大大学生命科学学院，教授。

研究领域

细菌病原体的耐药与致病性发生的分子机制研究

主持、参与项目 1. 结核病靶标研究（2008年科技部重大传染病防治专项） 2. 金黄色葡萄球菌临床菌株III-A CRISPR-Cas 系统的功能与机制研究（2017年面上项目） 3. 金黄色葡萄球菌群体感应信号分子AI-2的受体鉴定及调控致病性的分子机制（2019年面上项目） 4. 金黄色葡萄球菌耐药发生的分子机制研究（2019中科院先导专项）

近期论文

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1. Jiang Q, Jin Z, Sun B (2018). MgrA negatively regulates biofilm formation and detachment by repressing the expression of psm operons in Staphylococcus aureus. Appl Environ Microbiol 84:e01008-18. 2. Wen W, Liu B, Xue L, Zhu Z, Niu L, Sun B (2018). Autoregulation and virulence control by the toxin-antitoxin system SavRS in Staphylococcus aureus. Infect Immun 86:e00032-18. 3. Guan J, Wang W, Sun B (2017). Chromosomal targeting by the type III-A CRISPR-Cas system can reshape genomes in Staphylococcus aureus. mSphere 2:e00403-17. 4. Zhao C, Shu X, Sun B (2017). Construction of a gene knockdown system based on catalytically inactive ("dead") Cas9 (dCas9) in Staphylococcus aureus. Appl Environ Microbiol 83:e00291-17. 5. Liu X, Zhang S, Sun B (2016). SpoVG regulates cell wall metabolism and oxacillin resistance in methicillin-resistant Staphylococcus aureus strain N315. Antimicrob Agents Chemother 60:3455–3461. 6. Zhang S, Ma R, Liu X, Zhang X, Sun B (2015). Modulation of ccrAB expression and SCCmec excision by an inverted repeat element and SarS in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 59:6223-6232. 7. Chen C, Zhang X, Shang F, Sun H, Sun B, Xue T (2015). The Staphylococcus aureus protein-coding gene gdpS modulates sarS expression via mRNA-mRNA interaction. Infect Immun 83:3302-3310. 8. Hu J, Zhang X, Liu X, Chen C, Sun B (2015). Mechanism of reduced vancomycin susceptibility conferred by walK mutation in community-acquired methicillin-resistant Staphylococcus aureus strain MW2. Antimicrob Agents Chemother 59:1352-1355. 9. Xue T, You Y, Hong D, Sun H, Sun B (2011). The Staphylococcus aureus KdpDE two-component system couples extracellular K+ sensing and Agr signaling to infection programming. Infect Immun 79:2154-2167. 10. Zhao L, Xue T, Shang F, Sun H, Sun B (2010). Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence. Infect Immun 78:3506-3515. 11. Tao L, Wu X, Sun B (2010). Alternative sigma factor σH modulates prophage integration and excision in Staphylococcus aureus. PLoS Pathog 6:e1000888. 12. Shang F, Xue T, Sun H, Xing L, Zhang S, Yang Z, Zhang L, Sun B (2009). The Staphylococcus aureus GGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner. Infect Immun 77:2849-2856.