个人简介

EDUCATION AND RESEARCH EXPERIENCE 1985.09 - 1988.10 Graduate for M.S. degree. Kunming Institute of Zoology, Chinese Academy of Sciences. 1988.11 - 1992.09 Research Assistant. Anhui Institute of Occupational Health. 1992.10 - 1993.10 Guest Scientist. GSF-National Research Center for Environment and Health, Germany. 1994.09 - 1998.06 Graduate for Ph.D. degree. GSF-National Research Center for Environment and Health, Germany and, Nanjing Normal University. 1998.11 - 2001.12 Postdoctoral fellow. Department of Medical Genetics, University of Calgary, Canada. 2002.01 - 2004.12 Research Fellow. Institute of Chemistry and Cell Biology, Department of Cell Biology, Harvard Medical School. 2004.12 - 2018.12 Principal Investigator and Professor. Hefei National Laboratory for Physical Science at Microscale and, School of Life Science, University of Science and Technology of China. 2018.12 - present Principal Investigator and Professor. Hefei National Laboratory for Physical Science at Microscale and, The First Affiliated Hospital, School of Life Science, University of Science and Technology of China.

研究领域

1. Cellular and molecular regulation of mammalian meiosis. 2. Origins and mechanisms of mitotic and meiotic aneuploidy. 3. Molecular bases and mechanisms of human infertility.

CURRENT RESEARCH PROJECTS 1. Molecular regulation of human/mammalian meiosis. 2. Molecular mechanisms of oocyte and follicle development. 3. Identification of genetic mutations causing human spermatogenesis and oogenesis failure. 4. Origins and mechanisms of mitotic and meiotic aneuploidy.

近期论文

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1. Zhang B, Ma H, Khan T, Ma A, Li T, Zhang H, Gao JN, Zhou JT, Li Y……Zhang Y*, Shi Q (史庆华)*, A DNAH17 Missense Variant Causes Flagella Destabilization and Asthenozoospermia. J Exp Med, 217(2): 2020. 2. Yin H, Ma H, Hussain S, Zhang H, Xie X, Jiang L, Jiang X, Iqbal F, Bukhari I, Jiang H, Ali A, Zhong L, Li T, Fan S, Zhang B, Gao J, Li Y, Nazish J, Khan T, Khan M, Zubair M, Hao Q, Fang H, Huang J, Huleihel M, Sha J, Pandita TK, Zhang Y *, Shi Q (史庆华)*, A homozygous FANCM frameshift pathogenic variant causes male infertility. Genet Med, 21(1):62-70, 2019. 3. Jiang H, Gao Q, Zheng W, Yin S, Wang L, Zhong L, Ali A, Khan T, Hao Q, Fang H, Sun X, Xu P, Pandita TK, Jiang X*, Shi Q (史庆华)*, MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice. PLoS Genet, 14(5):e1007300, 2018. 4. Jiang L, Li T, Zhang X, Zhang B, Yu C, Li Y, Fan S, Jiang X, Khan T, Hao Q, Xu P, Nadano D, Huleihel M, Lunenfeld E, Wang PJ, Zhang Y *, Shi Q (史庆华)*, RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice. Curr Biol, 27(10):1498-1505 e1496, 2017. 5. Yin S, Jiang X, Jiang H, Gao Q, Wang F, Fan S, Khan T, Jabeen N, Khan M, Ali A, Xu P, Pandita TK, Fan HY, Zhang Y, Shi Q (史庆华)*, Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels. Development, 144(12):2165-2174, 2017. 6. Zhang Y, Zang Q, Zhang H, Ban R, Yang Y, Iqbal F, Li A*, Shi Q (史庆华)*, DeAnnIso: a tool for online detection and annotation of isomiRs from small RNA sequencing data. Nucleic Acids Res, 44(W1):W166-175, 2016. 7. Zhang Y, Yu Z, Ban R, Zhang H, Iqbal F, Zhao A, Li A *, Shi Q (史庆华)*, DeAnnCNV: a tool for online detection and annotation of copy number variations from whole-exome sequencing data. Nucleic Acids Res, 43(W1):W289-294, 2015. 8. Zhang Y, Zhong L, Xu B, Yang Y, Ban R, Zhu J, Cooke HJ, Hao Q, Shi Q (史庆华)*, SpermatogenesisOnline 1.0: a resource for spermatogenesis based on manual literature curation and genome-wide data mining. Nucleic Acids Res, 41(Database issue):D1055-1062, 2013. 9. Huang Y, Jiang L, Yi Q, Lv L, Wang Z, Zhao X, Zhong L, Jiang H, Rasool S, Hao Q, Guo Z, Cooke HJ, Fenech M, Shi Q (史庆华)*, Lagging chromosomes entrapped in micronuclei are not “lost” by cells. Cell Res, 22(5):932-935, 2012. 10. Shi Q (史庆华), King RW*. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature, 437(7061):1038-1042, 2005.