个人简介
Education and Research Experience
1994.09-1998.07 Department of Biology, Anhui University
Major: Microbiology, Degree: Bachelor of Science
1998.09-2004.11 School of Life Sciences, USTC
Major: Molecular and Cellular Biology, Degree: Ph.D.
2004.12-2007.04 School of Life Sciences, USTC
Post-doctoral researcher
2005.05-2005.12 Morehouse School of Medicine, USA
Visiting scholar
2007.05-2009.10 Max-Planck Institute of Biochemistry, Germany
Post-doctoral researcher
2010.01-present Hefei National Laboratary for Physical Science at the micro-scale,
University of Science and Technology of China, associated professor
研究领域
Kinetochore and Mitosis; Mitotic kinases; Ubiquitin-proteasome system in cell cycle control;
Genome instability and cancer.
近期论文
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1. Dou Z#, Liu X#, Wang W, Zhu T, Wang X, Xu L, Abrieu A, Fu C, Hill DL, Yao X*. 2015. Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment. Proc Natl Acad Sci U S A. 112(33): E4546-55.
2. Wang X, Yu H, Xu L, Zhu T, Zheng F, Fu C, Wang Z, Dou Z*. 2014. Dynamic autophosphorylation of Mps1 kinase is required for faithful mitotic progression. PLOS ONE. 9 (9): e0104723.
3. Zhu T#, Dou Z#, Qin B, Jin C, Wang X, Xu L, Wang Z, Zhu L, Liu F, Gao X, Ke Y, Wang Z, Aikhionbare F, Fu C, Ding X, Yao X*. 2013. Phosphorylation of Microtubule-binding Protein Hec1 by Mitotic Kinase Aurora B Specifies Spindle Checkpoint Kinase Mps1 Signaling at the Kinetochore. J. Biol. Chem. 288: 36149-36159. (# equal contribution)
4. Thebault P, Chirgadze DY, Dou Z, Blundell TL, Elowe S*, Bolanos-Garcia VM*. 2012. Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). Biochem J. 448: 321-8.
5. Dou Z, von Schubert C, Körner R, Santamaria A, Elowe S and Nigg EA*. 2011. Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1. PLoS ONE. 6(4):e18793.
6. Hua S, Wang Z, Jiang K, Huang Y, Ward T, Zhao L, Dou Z*, Yao X*. 2011. CENP-U Cooperates with Hec1 to Orchestrate Kinetochore-Microtubule Attachment. J Biol Chem. 286: 1627-38. (* corresponding author)
7. Zhao L, Chu J, Yuan K, Liu J, Yan F, Miao Y, Shaw A, Jin C, Dou Z*, Yao X*. 2010. Dimerization of CPAP orchestrates centrosome cohesion plasticity. J Biol. Chem. 285: 2488-97. (* corresponding author)
8. Elowe S, Dulla K, Uldschmid A, Li X, Dou Z, Nigg EA. 2010. Uncoupling BubR1 spindle checkpoint and chromosome congression functions. J Cell Sci. 123: 84-94.
学术兼职
Member of the American Society for Cell Biology
Member of the Chinese Society of Cell Biology
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