滕脉坤 - 中国科学技术大学 - 合肥微尺度物质科学国家研究中心

个人简介

中国科学技术大学生命科学学院教授。曾作为访问学者，分别在美国麻省理工学院生物系(1986.10-1988.6)、美国依里洛依大学厄本－香槟分校生理与生物物理系(1988.7-1989.7)、美国普度大学生命科学系(1992)、美国哈佛大学医学院Dana-Farber肿瘤研究所(1996.8-1997.11)等进修和交流。多年从事生物大分子晶体学和结构生物学研究，目前主要进行真核生物转录调控相关蛋白，DNA修复相关蛋白等的结构生物学研究；曾从事DNA寡聚核苷酸及其DNA-药物复合物的晶体学；病毒晶体学；T-细胞受体及其复合物的晶体学；葡萄糖异构酶蛋白质工程中的结构测定和蛋白质分子设计等研究工作。多年来主持和参与了多项国家科技部、基金委和中国科学院的重点和重大课题的研究工作。葡萄糖异构酶蛋白质工程研究获教育部高等教育科学技术二等奖(2001年)；安徽省教育厅科技进步一等奖（2000年）。蛇毒蛋白的结构生物学研究获安徽省科学技术二等奖（2010年）。目前主持和参加的研究课题有国家重大研究计划项目课题、国家自然科学基金委面上课题等。在国际、国内著名学术刊物共发表论文一百六十多篇。

研究领域

生化与分子生物学，结构生物学。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zhang, M., Liu, H., Gao, Y., Zhu, Z., Chen, Z., Zheng, P., Xue, L., Li, J., Teng, M., Niu, L., Structural Insights into the Association of Hif1 with Histones H2A-H2B Dimer and H3-H4 Tetramer., Structure, 24(10)：1810-1820, (2016). 2. Z. Liu, P. Chen a, X. Wang, G. Cai, L. Niu, M. Teng, & X. Li, Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Nucleic Acids Res. 42, 9470-9483, (2014). 3. Z. Shao, W. Yan, J. Peng, X. Zuo, Y. Zou, F. Li, D. Gong, R. Ma, J. Wu, Y. Shi, Z. Zhang, M. Teng, X. Li, Q. Gong, Crystal structure of tRNA m(1)G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate, NUCLEIC ACIDS RESEARCH, 42, 509-525, (2014). 4. H. Liu, H. Wang, M. Teng, X. Li, The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway, Acta Cryst. D70, 501-513, (2014). 5. F. Zeng, Z. Zou, L. Niu, X. Li, & M. Teng, AhV_aPA-induced vasoconstriction involves the IP3Rs-mediated Ca2+ releasing, Toxicon, 70, 107-113, (2013). 6. W. Zhang, F. Zeng, Y. Liu, Y. Zhao, H. Lv, L. Niu, M. Teng & X. Li, Crystal Structures and RNA-Binding Properties of the RRMs of hnRNP-L: Insights into Its Roles in Alternative-splicing Regulation, J. Biol. Chem., 288, 22636-49, (2013). 7. Y. Zhu, J. Dai, T. Zhang, P. Fang, H. Wang, Y. Jiang, X. Yu, T. Xia, L. Niu, Y. Guo & M. Teng, Structural insights into the neutralization mechanism of mAb 6C2 against ricin, J. Biol. Chem., 288, 25165-72, (2013). 8. H. Liu, Y. Gao, M. Zhang, X. Qiu, A. J. L. Cooper, L. Niu and M. Teng, Structures of enzyme–intermediate complexes of yeast Nit2: insights into its catalytic mechanism and different substrate specificity compared with mammalian Nit2, Acta Cryst. D69, 1470-81, (2013). 9. Y. Tao, C. Jin, X. Li, S. Qi, L. Chu, L. Niu, X. Yao & M. Teng, The structure of the FANCM-MHF complex reveals physical features for functional assembly, Nature Communications, 3, 782, Apr 17; doi:10.1038/ncomms1779, (2012). 10. J. Wang, M. Gossing, P. Fang, J. Zimmermann, X. Li, G. F. von Mollard, L. Niu, and M. Teng, Epsin N-terminal homology domains bind on opposite sides of two SNAREs, Proc Natl Acad Sci USA, 108 (30):12277-82; (2011). 11. P. Fang, X. Li, J. Wang, L. Niu and M. Teng, Structural basis for the specificity of GAE domain of yGGA2 for its accessory proteins Ent3 and Ent5，Biochemistry, 49(36), 7949-55, (2010). 12. Y. Liu, Y. Hu, X. Li, L. Niu, M. Teng, Crystal structure of human nascent polypeptide-associated complex domain reveals a nucleic acid-binding region on the NACA subunit, Biochemistry, 49(13): 2890-6, (2010). 13. Y. Liu, H. Huang, B. Zhou, S. Wang, Y. Hu, X. Li, J. Liu, J. Zang, L. Niu, J. Wu, J. Zhou, M. Teng and Y. Shi, Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing, J. Biol. Chem., 285，4251-4262, (2009). 14. J. Wang, B. Shen, M. Guo, X. Lou, Y. Duan, X. Cheng, M. Teng, L. Niu, Q. Liu, Q. Huang, Q. Hao, (2005), The Blocking Effect and Crystal Structure of Natrin Toxin, a CRISP Protein from Naja atra Venom that Targets BKCa Channel; Biochemistry-US, 44，10145-10152. 15. M. Guo, M. Teng, L. Niu, Q. Liu, Q. Huang, and Q. Hao, (2005), Crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a K+ channel inhibitor-like fold, J. Biol. Chem., 280, 12405 – 12412. 16. Y. Ghendler, M. Teng, J. Liu, T. Witte, J. Liu, K. Kim, P. Kern, H. Chang, J. Wang and E. Reinherz, (1998), Differential thymic selection outcomes stimulated by focal structural alteration in peptide/MHC ligands, Proc. Natl. Acad. Sci. U.S.A., 95, 10061-10066. 17. M. Teng, et al, (1998), Crystal Structure of N15 TCR in Complex with its Peptide/MHC(pMHC) Ligand: Identification of a common docking topology with substantial variation among different TCR-pMHC complexes, Current Biology, 8, 409-412.

学术兼职

中国生物物理学会、中国晶体学会理事。