个人简介
EDUCATION
1980.09 - 1984.07 Department of Appied Physics, Harbin University of Science and Technology, undergraduate student
1987.09 - 1990.05 Department of Applied Physics, Harbin University of Science and Technology, graduate student
2000.09 - 2003.09 Laboratoire d’Enzymologie et Biochimie Structurales (LEBS), CNRS, France, PhD
PROFESSIONAL EXPERIENCE
1984.07 - 1987.08 Department of Appied Physics, Harbin University of Science and Technology, Assistant professor, Scientific Research and Teaching
1990.06 - 1998.08 Department of Applied Physics, Harbin University of Science and Technology, Lecturer, Scientific Research and Teaching
1998.08 - 1999.03 Department of Applied Physics, Harbin University of Science and Technology, Associate Professor, Scientific Research and Teaching "Modern Optics"
1999.03 - 2000.03 Institut de Physique Nucleaire (IPN), CNRS, France
2003.09 - 2004.02 Laboratoire d’Enzymologie et Biochimie Structurales (LEBS), CNRS, France, Postdoc
2004.04 - 2007.05 Protein Research Institute, Tongji University, Professor
2007.05 - University of Science and Technology of China, Professor
研究领域
1. Surface proteins and virulence factors from human pathogens.
2. Membrane proteins involved in bacterial drug resistance.
近期论文
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1. Yang HB#, Hou WT#, Cheng MT#, Jiang YL*, Chen Y*, Zhou CZ*. Structure of a MacAB-like efflux pump from Streptococcus pneumoniae. Nature Communications. 2018 January; 9(1):196.
2. Jiang YL#, Wang XP#, Sun H#, Han SJ, Li WF, Cui N, Li GM, Zhang JY, Cheng W, Cao DD, Zhang ZY, Zhang CC*, Chen Y*, Zhou CZ*. Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. Proceedings of the National Academy of Sciences USA. 2018 January; 115(2):403-408.
3. Jiang YL#, Jin H#, Yang HB, Zhao RL, Wang SL, Chen Y*, Zhou CZ*. Defining the enzymatic pathway for polymorphic O-glycosylation of the pneumococcal serine-rich repeat protein PsrP. Journal of Biological Chemistry. 2017 Feb; 292(15):6213-6224.
4. Yu LY#, Cheng W#, Zhou K#, Li WF, Yu HM, Gao X, Shen X, Wu Q, Chen Y*, Zhou CZ*. Structures of an all-α protein running along the DNA major groove. Nucleic Acids Research. 2016 Mar; 44(8): 3936–3945.
5. Jia N, Liu N, Cheng W, Jiang YL, Sun H, Chen LL, Peng J, Zhang Y, Ding YH, Zhang ZH, Wang X, Cai G, Wang J, Dong MQ, Zhang Z, Wu H, Wang HW*, Chen Y*, Zhou CZ*. Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO Reports. 2016 Feb; 17(2): 235-48.
6. Bai XH#, Chen HJ#, Jiang YL, Wen Z, Huang Y, Cheng W, Li Q, Qi L, Zhang JR*, Chen Y*, Zhou CZ*. Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis. J Biol Chem. 2014 Aug; 289(34):23403-16.
7. Shi WW#, Jiang YL#, Zhu F, Yang YH, Shao QY, Yang HB, Ren YM, Wu H*, Chen Y*, Zhou CZ*. Structure of a novel O-GlcNAc transferase GtfA reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins. J Biol Chem. 2014 Jul; 289(30):20898-20907.
8. Yang YH#, Jiang YL#, Zhang J, Wang L, Bai XH, Zhang SJ, Ren YM, Li N, Zhang YH, Zhang Z, Gong Q, Mei Y, Xue T, Zhang JR, Chen Y*, Zhou CZ*. Structural insights into SraP-mediated Staphylococcus aureusadhesion to host cells. PLoS Pathogens. 2014 June; 10(6): e1004169.
9. Yu WL, Jiang YL, Pikis A, Cheng W, Bai XH, Ren YM, Thompson J, Zhou CZ*, Chen Y*. Structural insights into the substrate specificity of a 6-phospho-β-glucosidase BglA-2 from Streptococcus pneumoniaeTIGR4. J Biol Chem. 2013 May; 288(21):14949-58.
10. Cheng W#, Wang L#, Jiang YL, Bai XH, Chu J, Li Q, Yu G, Liang QL, Zhou CZ* and Chen Y*. Structural insights into the substrate specificity of Streptococcus pneumoniae β(1,3) galactosidase BgaC. J Biol Chem. 2012; 287(27):22910-8.
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