蔡刚 - 中国科学技术大学 - 合肥微尺度物质科学国家研究中心

个人简介

EDUCATION AND RESEARCH EXPERIENCE 2010.11-present Professor, University of Science and Technology 2006.03-2010.11 Research Associate, the Scripps Research Institute, USA 2001.09-2006.03 Ph.D. Shanghai Institutes for Biological Sciences 1997.09-2001.07 B.S. Anhui University B.S. in Microbiology, 2001

研究领域

I am interested in examining the structures and functional interactions of key macromolecular complexes responsible for regulation of chromatin structure and genomic stability, aiming at a structural understanding of the molecular mechanism and designing novel pharmaceuticals for cancer therapy.

近期论文

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1. Wang, X., Ran, T., Zhang, X., Xin, J., Zhang, Z., Wu, T., Wang, W. and Cai, G*. (2017) 3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP. Science, 358, 1206-1209. 2. Xin, J#., Xu, Z#.,Wang, X#., Tian Y., Zhang, Z. and Cai, G*.（2019） Structural basis of allosteric regulation of Tel1/ATM kinase. Cell Research 29: 655–665. (Cover story) 3. Qiu, S#., Liu, S#., Zaoti, Z., Wang, X*, Cai, G*. (2019）Modulation of Fatty Acid Synthase by ATR checkpoint kinase Rad3. Journal of Molecular Cell Biology 11: 1098-1100. 4. Zhang, X., Wang, X*., Zhang, Z., and Cai, G*. (2019) Structure and Functional Interactions of INO80 Actin/Arp Module. J Mol Cell Biol. 11: 345-355. (cover story) 5. Wang, X*., Ahmad, S., Zhang, Z., Côté, J., Cai, G*. (2018) Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex. Nature communications, 9, 1147. 6. Zhang, Z., Wang, X*., Xin, J., Ding, Z., Liu, S., Fang, Q., Yang, N., Xu, R., Cai, G*. (2018) Architecture of SWI/SNF chromatin remodeling complex. Protein Cell, 9, 1045-1049. 7. Wang, X., Chu, H., Lv, M., Zhang, Z., Qiu, S., Liu, H., Shen, X., Wang, W*., Cai, G*. (2016) Structure of the intact ATM/Tel1 kinase. Nature communications 7, 11655. 8. Wang, X., Sun, Q., Ding, Z., Ji, J., Wang, J., Kong, X., Yang J.H., and Cai, G.* (2014) Redefining the Modular Organization of the Core Mediator Complex. Cell Research 24, 796-808. (cover story) 9. Wang, X., Wang, J., Ding, Z., Ji, J., Sun, Q., and Cai, G.* (2013) Structural flexibility and functional interaction of mediator Cdk8 module, Protein & Cell, 12.4, 4(12): 911~920 (cover story)