郭昌 - 中国科学技术大学 - 合肥微尺度物质科学国家研究中心

个人简介

2018.03 - 至今特任教授，博士生导师，合肥微尺度物质科学国家研究中心 2017.02-2018.02 特任研究员，中国科学技术大学，合肥微尺度物质科学国家研究中心 2013.08-2017.01 博士后，德国明斯特大学 2007.09-2013.06 博士，中国科学技术大学 2003.08-2007.06 学士，中国科学技术大学

研究领域

不对称电化学反应、联合催化、天然产物全合成。以新型不对称催化研究为基础提高反应活性与选择性，并将这些方法学用于天然产物的合成，发展高效、原子经济性和环境友好的现代有机合成化学

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Xu, X.; Wang, M.; Peng, L.; Guo, C.* Nickel-catalyzed asymmetric propargylation for the synthesis of axially chiral 1,3-disubstituted allenes. J. Am. Chem. Soc. 2022, 144, 21022―21029. Zhang, J.; Chang, X.; Xu, X.; Wang, H.; Peng, L.; Guo, C.* Nickel-catalyzed switchable 1,3-dienylation and enantioselective allenylation of phosphine oxides. Nat. Commun. 2022, 13, 7049. Liang, K.; Zhang, Q.; Guo, C.* Nickel-catalyzed switchable asymmetric electrochemical functionalization of alkenes. Sci. Adv. 2022, 8, eadd7134. Zhang, Q.; Liang, K.; Guo, C.* Enantioselective nickel-catalyzed electrochemical radical allylation. D. Angew. Chem. Int. Ed. 2022, 61, e202210632. He, Z.; Peng, L.; Guo, C.* Catalytic stereodivergent total synthesis of amathaspiramide D. Nat. Synth. 2022, 1, 393-400. Hu, Q.; He, Z.; Peng, L.; Guo, C.* Combining nickel and squaramide catalysis for the stereodivergent α-propargylation of oxindoles. Nat. Synth. 2022, 1, 322-331. Xu, X.; Peng, L.; Chang, X.; Guo, C.* Ni/Chiral Sodium Carboxylate Dual Catalyzed Asymmetric O-Propargylation. J. Am. Chem. Soc. 2021, 143, 21048-21055. Peng, L.; Wang, H.; Guo, C.* Copper-Catalyzed Enantioselective Difluoromethylation of Amino Acids via Difluorocarbene. J. Am. Chem. Soc. 2021, 143, 6376―6381. Chang, X.; Zhang, J.; Peng, L.; Guo, C.* Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation. Nat. Commum. 2021, 12, 299. Zhang, Q.; Liang, K.; Guo, C.* Asymmetric Electrochemical Arylation in the Formal Synthesis of (+)-Amurensinine. CCS Chem. 2021, 3, 338. Chang, X.; Zhang, J.; Zhang, Q.; Guo, C.* Merging Electrosynthesis and Bifunctional Squaramide Catalysis in the Asymmetric Detrifluoroacetylative Alkylation Reactions. Angew. Chem. Int. Ed. 2020, 59, 18500―18504. Peng, L.; He, Z.; Xu, X.; Guo, C.* Cooperative Ni/Cu-Catalyzed Asymmetric Propargylic Alkylation of Aldimine Esters. Angew. Chem. Int. Ed. 2020, 59, 14270―14274. Chang, X.; Zhang, Q.; Guo, C.* Asymmetric Electrochemical Transformation. Angew. Chem. Int. Ed. 2020, 59, 12612―12622. Wang, H.; Hu, Q.; Wang, M.; Guo, C.* Enantioselective [4+2] Annulation to the Concise Synthesis of Chiral Dihydrocarbazoles. iScience 2020, 23, 100840. Zhang, Q.; Chang, X.; Peng, L.; Guo, C.* Asymmetric Lewis Acid Catalyzed Electrochemical Alkylation. Angew. Chem. Int. Ed. 2019, 58, 6999―7003. Chang, X.; Zhang, Q.; Guo, C.* Switchable Smiles Rearrangement for Enantioselective O-Aryl Amination. Org. Lett. 2019, 21, 4915―4918. Wang, H.; Guo, C.* Enantioselective γ‐Addition of Pyrazole and Imidazole Heterocycles to Allenoates Catalyzed by Chiral Phosphine. Angew. Chem. Int. Ed. 2019, 58, 2854―2858. Chang, X.; Zhang, Q.; Guo. C.* Electrochemical Reductive Smiles Rearrangement for C−N Bond Formation. Org. Lett. 2019, 21, 10―13. Guo, C.*; Janssen-Müller, D.; Fleige, M.; Lerchen, A.; Daniliuc, C. G.; Glorius, F.*Mechanistic studies on a cooperative NHC organocatalysis/palladium catalysis system: uncovering significant lessons for mixed chiral Pd(NHC)(PR3) catalyst design. J. Am. Chem. Soc. 2017, 139, 4443―4451. Guo, C.; Fleige, M.; Janssen-Müller, D.; Daniliuc, C. G.; Glorius, F.* Cooperative N-heterocyclic carbene/palladium-catalyzed enantioselective umpolung annulations, J. Am. Chem. Soc. 2016, 138, 7840―7843. Guo, C.; Fleige, M.; Janssen-Müller, D.; Daniliuc, C. G.; Glorius, F. * Switchable selectivity in an NHC-catalysed dearomatizing annulation reaction, Nat. Chem. 2015, 7, 842―847. Guo,C.; Sahoo, B.; Daniliuc, C. G.; Glorius, F.*N-Heterocyclic carbene catalyzed switchable reactions of enals with azoalkenes: formal [4+3] and [4+1] annulations for the synthesis of 1,2-diazepines and pyrazoles, J. Am. Chem. Soc. 2014, 136, 17402―17405. Guo, C.; Schedler, M.; Daniliuc, C. G.; Glorius,F.*N-Heterocyclic carbene catalyzed formal [3+2] annulation reaction of enals: an efficient enantioselective access to spiro-heterocycles, Angew. Chem. Int. Ed. 2014, 53, 10232―10236. Guo. C.; Song, J.; Gong, L.-Z. Biomimetic Asymmetric 1,3-Dioplar Cycloaddition: Amino Acid Precursors in Biosynthesis Serve as Latent Azomethine Ylides. Org. Lett. 2013, 11, 2676―2679. Guo, C.; Song, J.; Huang, J.-Z.; Chen, P.-H.; Luo, S.-W.; Gong, L.-Z. * Core-structure-oriented asymmetric organocatalytic substitution of 3-hydroxyoxindoles: application in the enantioselective total synthesis of (+)-folicanthine. Angew. Chem. Int. Ed. 2012, 51, 1046―1050. Guo, C.; Song, J.; Luo, S.-W.; Gong, L.-Z. * Enantioselective oxidative cross-coupling reaction of 3-indolylmethyl C-H bonds with 1,3-dicarbonyls using a chiral Lewis acid-bonded nucleophile to control stereochemistry. Angew. Chem. Int. Ed. 2010, 49, 5558―5562. Guo, C.; Xue, M.-X.; Zhu, M.-K.; Gong, L.-Z.* Organocatalytic asymmetric formal [3+2] cycloaddition reaction of isocyanoesters to nitroolefins leading to highly optically active dihydropyrroles. Angew. Chem. Int. Ed. 2008, 47, 3414―3417.