研究领域

Analytical Chemistry Bioanalytical Chemistry Materials Chemistry Optics and Imaging Sensor Science Analytical Laser Spectroscopy and Imaging Electrophoretic Separations

Our research group applies Raman spectroscopy and spectroscopically resolved two and three dimensional imaging to chemical and biomedical problems. It also specializes in high speed video microscopy. We are interested in problems at scales ranging from single molecules to tissue specimens. We are leaders in Raman microspectroscopy and microscopic imaging. We develop new spectroscopic instrumentation based on modern photonics technology and new chemometric and other image processing methods for generation of hyperspectral image contrast. A core interest is the chemistry that governs the properties of musculo-skeletal tissues. We use our unique Raman spectroscopic imaging and dynamic microspectroscopy capabilities to study normal and pathological development and failure mechanisms of these tissues at every stage of the life cycle from embryo through maturity. We study how these tissues change over time and how they respond to the imposition of normal and traumatic external loads. The work has led to new insights into the effects of skeletal birth defects such as craniosynotosis and osteogenesis imperfecta, into the tissue changes associated with metababolic diseases such as osteoporosis and osteoarthritis and into the biomechanics of bone tissue and cartilage. The same technology is also applied to characterization of biomaterials ranging from heart valve replacements to dental cements. Additionally we have unique capabilities and facilities for high frame rate fluorescence imaging at the single molecule level. The lab has used supra-video rate imaging to study dynamics of DNA and RNA electrophoretic migration and to study the statistics of electrophoretic dynamics. Our work is interdisciplinary and requires close collaboration with biomedical research groups in the medical and dental schools and in the engineering college. Uniquely within the chemistry department, we operate a core Raman spectroscopy facility that brings graduate students and postdoctoral fellows into contact with life scientists from across the university for short and long-term projects.

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M Raghavan, ND Sahar, DH Kohn, MD Morris, “Age-specific profiles of tissue-level composition and mechanical properties in murine cortical bone”, Bone, 2012 (In press, corrected proof) [link] PI Okagbare, MD Morris, “Polymer-capped fiber-optic Raman probe for non-invasive Raman spectroscopy”, Analyst, 2012,137, 77-81[link] J-D McElderry, MR Kole, MD Morris, "Repeated freeze-thawing of bone tissue affects Raman bone quality measurements", J Biomed Opt., 2011, 16, 071407 [link] J Xu, P Zhu, Z Gan, MD Morris, A Ramamoorthy, "Solid-state NMR spectroscopy provides atomic-level insights into the dehydration of cartilage", J Phys Chem B., 2011, 115(33), 9948-9954 [link] FW Esmonde-White, KA Esmonde-White, MR Kole, SA Goldstein, BJ Roessler and MD Morris, "Biomedical tissue phantoms with controlled geometric and optical properties for Raman spectroscopy and tomography", Analyst, 2011, 136 (21), 4437 - 4446 [link] KA Esmonde-White, FW Esmonde-White, MD Morris, and BJ Roessler, “Fiber-optic Raman Spectroscopy of Joint Tissues,” Analyst (2011) [link]. FW Esmonde-White, KA Esmonde-White, and MD Morris, “Minor Distortions with Major Consequences: Correcting Distortions in Imaging Spectrographs,” Appl Spectrosc 65 , 85 (2011) [link] PI Okagbare, FWL Esmonde-White, SA Goldstein, and MD Morris, “Development of non-invasive Raman spectroscopy for in vivo evaluation of bone graft osseointegration in a rat model,” Analyst 135, 3142 (2010) [link] J Xu, P Zhu, Z Gan, ND Sahar, M Tecklenburg, MD Morris, DH Kohn, A Ramamoorthy, "Natural-abundance 43Ca solid-state NMR spectroscopy of bone", J Am Chem Soc., 2010, 132(33), 11504-11509 [link] M Raghavan, ND Sahar, RH Wilson, MA Mycek, N Pleshko, DH Kohn, MD Morris, “Quantitative polarized Raman spectroscopy in highly turbid bone tissue”, Journal of Biomedical Optics, 2010, 2010; 15: 037001-07 [link] M. V. Schulmerich, J. H. Cole, J. M. Kreider, F. W.L. Esmonde-White, K. A. Dooley, S. A. Goldstein, and M. D. Morris, “Transcutaneous Raman Spectroscopy of Murine Bone In Vivo,” Applied Spectroscopy 63 , 286-295 (2009) [link]. K. A. Esmonde-White, G. S. Mandair, F. Raaii, J. A. Jacobson, B. S. Miller, A. G. Urquhart, B. J. Roessler, and M. D. Morris, “Raman spectroscopy of synovial fluid as a tool for diagnosing osteoarthritis,” J. Biomed. Opt. 14 , 034013 (2009) [link]. KA Dooley, MD Morris, J McCormack, DP Fyhrie, "Stress mapping of undamaged, strained and failed regions of bone using Raman spectroscopy", J. Biomed. Opt. 14, 044018 (2009) [link] P Zhu, J Xu, ND Sahar, MD Morris, DH Kohn, A Ramamoorthy, "Time-resolved dehydration-induced structural changes in an intact bovine cortical bone revealed by solid-state NMR spectroscopy", J Am Chem Soc, 2009, 131(47), 17064-65 [link] MD Morris, P Matousek (Eds.), "Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields", Springer (2010) [link] GS Mandair, MD Morris, Raman Assessment of Bone Quality, in Clinical Orthopedics in Clinical Orthopedics and Related Research (2010) [link] NA Macleod, MD Morris & P Matousek, "Characterization of deep layers of tissue and powders: Spatially offset Raman and transmission Raman spectroscopy", Emerging Raman Applications and Techniques in Biomedical and Pharmacuetical Fields, 47-69 (2010) [link] GS Mandair and MD Morris, "Biomedical Applications of Raman Imaging, in Raman, Infrared and Near-infrared Chemical Imaging", edited by Ozaki, Y and Sasic, S., J. Wiley (2010) [link] F. W. Esmonde-White and M. D. Morris, “Raman Imaging and Raman Mapping,” Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields , 97–110 (2010) [link] K Esmonde-White, M Raghavan & MD Morris, "Raman Scattering I: Speciation and Analysis" in Encyclopedia of Applied Spectroscopy, edited by David Andrews, J. Wiley (2009) [link]