Capaldi, Andrew - The University of Arizona - Department of Molecular and Cellular Biology

个人简介

Teal Brechtel, BS, Biology, 2012, Millsaps College Jacob Cecil, BS, Biochem and MCB, 2016, University of Tennessee

研究领域

Structure and function of the TORC1 signaling network TORC1-body formation and the role of protein agglomeration in cell signaling Cooperation between the TORC1 and other signaling pathways

近期论文

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Kunkel J, Luo X, Kaplan ME, & Capaldi AP (2019) Integrated TORC1 and PKA signaling control the temporal activation of glucose-induced gene expression in yeast. Nature Communications. https://doi.org/10.1038/s41467-019-11540-y Sullivan A, Wallace RL, Wellington, R, Luo X & Capaldi AP (2018) Multi-layered regulation of TORC1-body formation in budding yeast. MBoC. https://doi.org/10.1091/mbc.E18-05-0297 Worley J, Sullivan A, Luo X, Kaplan ME, & Capaldi AP (2015) Genome-Wide Analysis of the TORC1 and Osmotic Stress Signaling Network in Saccharomyces cerevisiae. G3 (Bethesda) 6(2):463-474. pdf Hughes Hallett JE, Luo X, & Capaldi AP (2015) Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast. Elife 4. pdf Hughes Hallett JE, Luo X, & Capaldi AP (2014) State transitions in the TORC1 signaling pathway and information processing in Saccharomyces cerevisiae. Genetics 198(2):773-786. pdf Worley J, Luo X, & Capaldi AP (2013) Inositol pyrophosphates regulate cell growth and the environmental stress response by activating the HDAC Rpd3L. Cell Reports 3(5):1476-1482. pdf Buchan JR, Capaldi AP, & Parker R (2012) TOR-tured yeast find a new way to stand the heat. Mol Cell 47(2):155-157. pdf Capaldi AP (2010) Analysis of gene function using DNA microarrays. Methods Enzymol 470:3-17. pdf Capaldi AP, et al. (2008) Structure and function of a transcriptional network activated by the MAPK Hog1. Nat Genet 40(11):1300-1306. pdf Spence GR, Capaldi AP, & Radford SE (2004) Trapping the on-pathway folding intermediate of Im7 at equilibrium. J Mol Biol 341(1):215-226. Friel CT, Capaldi AP, & Radford SE (2003) Structural analysis of the rate-limiting transition states in the folding of Im7 and Im9: similarities and differences in the folding of homologous proteins. J Mol Biol 326(1):293-305. Capaldi AP, Kleanthous C, & Radford SE (2002) Im7 folding mechanism: misfolding on a path to the native state. Nat Struct Biol 9(3):209-216. Gorski SA, Capaldi AP, Kleanthous C, & Radford SE (2001) Acidic conditions stabilise intermediates populated during the folding of Im7 and Im9. J Mol Biol 312(4):849-863. Ferguson N, Li W, Capaldi AP, Kleanthous C, & Radford SE (2001) Using chimeric immunity proteins to explore the energy landscape for alpha-helical protein folding. J Mol Biol 307(1):393-405. Capaldi AP, Shastry MC, Kleanthous C, Roder H, & Radford SE (2001) Ultrarapid mixing experiments reveal that Im7 folds via an on-pathway intermediate. Nat Struct Biol 8(1):68-72. Ferguson N, Capaldi AP, James R, Kleanthous C, & Radford SE (1999) Rapid folding with and without populated intermediates in the homologous four-helix proteins Im7 and Im9. J Mol Biol 286(5):1597-1608. Capaldi AP, Ferguson SJ, & Radford SE (1999) The Greek key protein apo-pseudoazurin folds through an obligate on-pathway intermediate. J Mol Biol 286(5):1621-1632. Capaldi AP & Radford SE (1998) Kinetic studies of beta-sheet protein folding. Curr Opin Struct Biol 8(1):86-92.