Bull, Steven - University of Bath - Department of Chemistry

研究领域

Synthetic chemistry is the cornerstone of the natural sciences where it serves as a fundamental technology for the preparation of structurally complex materials on a molecular scale. Complexity in molecules is often associated with chirality - the fundamental property of a structure that renders it non-superimposable on its mirror image. The synthesis of chiral molecules is a challenging undertaking and we are interested in developing novel, atom efficient strategies for the asymmetric synthesis of highly desirable chiral fragments. Towards this aim, my research interests can be categorised into four main areas - asymmetric synthesis, biotransformations, combinatorial chemistry and bioorganic chemistry. Research workers within my group will be exposed to a wide range of 'state of the art' synthetic and analytical techniques which are ideally suited to a career in both academia and industry. For more information visit the Bull Group homepage. Asymmetic Synthesis Biotransformations Combinatorial Chemistry Bioorganic Synthesis

近期论文

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A boronic acid-based fluorescent hydrogel for monosaccharide detection Xu, S., Sedgwick, A. C., Elfeky, S. A., Chen, W., Jones, A. S., Williams, G. T., Jenkins, A. T. A., Bull, S. D., Fossey, J. S. & James, T. D., 21 May 2019, In : Frontiers of Chemical Science and Engineering. A Selective Deprotection Strategy for the Construction of trans-2-Aminocyclopropanecarboxylic Acid Derived Peptides Boddaert, T., Taylor, J. E., Bull, S. D. & Aitken, D. J., 4 Jan 2019, In : Organic Letters. 21, 1, p. 100-103 4 p. Continuous-flow liquid-phase dehydrogenation of 1,4-cyclohexanedione in a structured multichannel reactor Ashraf, M. A., Tan, J., Davidson, M. G., Bull, S., Hutchby, M., Mattia, D. & Plucinski, P., 1 Jan 2019, In : Reaction Chemistry & Engineering. 4, 1, p. 27-40 14 p. Correction: Simple Chiral Derivatization Protocols for 1H NMR and 19F NMR Spectroscopic Analysis of the Enantiopurity of Chiral Diols (Journal of Organic Chemistry (2009) 741:1 (427-430) DOI: 10.1021/jo8019187) Lozano Yeste, S., Powell, M. E., Bull, S. D. & James, T. D., 19 Jul 2019, In : Journal of Organic Chemistry. 84, 14, 1 p. Correction: ESIPT-based ratiometric fluorescence probe for the intracellular imaging of peroxynitrite (Chemical Communications (2018) 54 (9953-9956) DOI: 10.1039/C8CC04919J) Wu, L., Wang, Y., Weber, M., Liu, L., Sedgwick, A. C., Bull, S. D., Huang, C. & James, T. D., 28 Mar 2019, In : Chemical Communications. 55, 25, p. 3674 1 p. Dual enzyme activated fluorescein based fluorescent probe Odyniec, M. L., Gardiner, J. E., Sedgwick, A. C., He, X. P., Bull, S. D. & James, T. D., 1 Mar 2019, In : Frontiers of Chemical Science and Engineering. Dynamic stall alleviation through mini-tabs Bull, S. C., Chiereghin, N., Gursul, I. & Cleaver, D. J., 6 Jan 2019, AIAA Scitech 2019 Forum. American Institute of Aeronautics and Astronautics Inc. ESIPT-based fluorescence probe for the ratiometric detection of superoxide Wu, L., Liu, L., Han, H. H., Tian, X., Odyniec, M. L., Feng, L., Sedgwick, A. C., He, X. P., Bull, S. D. & James, T. D., 21 Feb 2019, In : New Journal of Chemistry. 43, 7, p. 2875-2877 3 p. Exposing the Interplay Between Enzyme Turnover, Protein Dynamics and the Membrane Environment in Monoamine Oxidase B Jones, H. B. L., Crean, R. M., Mullen, A., Kendrick, E., Bull, S. D., Wells, S. A., Carbery, D. R., MacMillan, F., van der Kamp, M. W. & Pudney, C. R., 7 May 2019, In : Biochemistry. 58, 18, p. 2362-2372 11 p. Long wavelength TCF-based fluorescence probe for the detection of Alkaline Phosphatase in live cells Gwynne, L., Sedgwick, A. C., Gardiner, J. E., Williams, G. T., Kim, G., Maillard, J. Y., Jenkins, T., Bull, S. D., Sessler, J. L., Yoon, J. & James, T. D., 30 Apr 2019, In : Frontiers in Chemistry. 7, APR, 255. 1,1-Diacyloxy-1-phenylmethanes as versatile N-acylating agents for amines Chapman, R. S. L., Tibbetts, J. D. & Bull, S. D., 21 May 2018, In : Tetrahedron. 10 p. A happy couple Marken, F. & Bull, S. D., 1 Jul 2018, In : Nature Catalysis. 1, 7, p. 484-485 2 p.Research output: Contribution to journal › Short survey 'AND'-based fluorescence scaffold for the detection of ROS/RNS and a second analyte Odyniec, M. L., Sedgwick, A. C., Swan, A. H., Weber, M., Tang, T. M. S., Gardiner, J. E., Zhang, M., Jiang, Y. B., Kociok-Kohn, G., Elmes, R. B. P., Bull, S. D., He, X. P. & James, T. D., 27 Jun 2018, In : Chemical Communications. 54, p. 8466-8469 4 p. An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates Sedgwick, A. C., Dou, W. T., Jiao, J. B., Wu, L., Williams, G. T., Jenkins, A. T. A., Bull, S. D., Sessler, J. L., He, X. P. & James, T. D., 31 Oct 2018, In : Journal of the American Chemical Society. 140, 43, p. 14267-14271 5 p. A simple umbelliferone based fluorescent probe for the detection of nitroreductase Sedgwick, A. C., Hayden, A., Hill, B., Bull, S. D., Elmes, R. B. P. & James, T. D., 1 Jun 2018, In : Frontiers of Chemical Science and Engineering. 12, 2, p. 311-314 4 p. Boronate-Based Fluorescence Probes for the Detection of Hydrogen Peroxide Lampard, E. V., Sedgwick, A. C., Sun, X., Filer, K. L., Hewins, S. C., Kim, G., Yoon, J., Bull, S. D. & James, T. D., 1 Mar 2018, In : ChemistryOpen. 7, 3, p. 262-265 Correction: A bodipy based hydroxylamine sensor (Chemical Communications (2017) 53 (10441-10443) DOI: 10.1039/C7CC05872A)Sedgwick, A. C., Chapman, R. S. L., Gardiner, J. E., Peacock, L. R., Kim, G., Yoon, J., Bull, S. D. & James, T. D., 4 Oct 2018, In : Chemical Communications. 54, 77, p. 10922 1 p. Correction: Boronate based fluorescence (ESIPT) probe for peroxynitrite(Chem. Commun. (2016) 52 (12350–12352) DOI: 10.1039/C6CC06829D)Sedgwick, A. C., Sun, X., Kim, G., Yoon, J., Bull, S. D. & James, T. D., 28 Sep 2018, In : Chemical Communications. 54, 76, p. 10775 1 p. Dual-function cellulose composites for fluorescence detection and removal of fluoride Li, M., Liu, Z., Wang, H. C., Sedgwick, A. C., Gardiner, J. E., Bull, S. D., Xiao, H. N. & James, T. D., 1 Feb 2018, In : Dyes and Pigments. 149, p. 669-675 7 p. Dye Displacement Assay for Saccharides using Benzoxaborole Hydrogels Lampard, E. V., Sedgwick, A. C., Sombuttan, T., Williams, G. T., Wannalerse, B., Jenkins, A. T. A., Bull, S. D. & James, T. D., 1 Mar 2018, In : ChemistryOpen. 7, 3, p. 266-268 Electrochemically Driven C-H Hydrogen Abstraction Processes with the Tetrachloro-Phthalimido-N-Oxyl (Cl4PINO) Catalyst Marken, F., Buckingham, M. A., Bull, S., Cunningham, W., Buchard, A., Folli, A. & Murphy, D., 1 Aug 2018, In : Electroanalysis. 30, 8, p. 1706-1713 ESIPT-based fluorescence probe for the rapid detection of hypochlorite (HOCl/ClO-)Wu, L., Yang, Q., Liu, L., Sedgwick, A. C., Cresswell, A. J., Bull, S. D., Huang, C. & James, T. D., 4 Jul 2018, In : Chemical Communications. 54, 61, p. 8522-8525 4 p.