Braun, Dieter - Ludwig-Maximilians-Universität München

个人简介

2015 Deutscher Gründerpreis für NanoTemper 2014 Simons Foundation: Collaboration on the Origins of Life ($1.5 Mio for five years) 2012 Prodekan Step Award for NanoTemper Deutscher Innovationspreis for NanoTemper 2011 Klung-Wilhelmy Weberbank Price 2010 ERC Starting Grant 2008 Startup Company NanoTemper 2007 Full professor for Systems Biophysics at the LMU Munich Offers for professorships in Leipzig, Bayreuth and Munich Habilitation 2005 Parental Leave: half time position for 1.5 years 2003-2007 Independent Emmy Noether research group LMU Munich with Hermann Gaub 2000-2003 Postdoc with Albert Libchaber at Rockefeller University (USA) 2001 Schloessmann Award in Optical Methods in Modern Biology 2000 PhD, summa cum laude 1997-2000 PhD, Max Planck Institute of Biochemistry, Martinsried 1997 Diploma Thesis with Peter Fromherz at MPI of Biochemistry, Martinsried 1993-1997 Study of Physics, Technical University Munich 1991-1993 Study of Physics, University of Ulm

研究领域

Can we understand the mechanisms that lead to the Darwinian evolution of the first living molecules on the early Earth? Our experiments recreate the first steps of molecular evolution using microscale experiments. We study the nonequilibrium settings how dead molecules could be combined by physical forces into an autonomous mechanism of Darwinian evolution. One of our focus are physical non-equilibria such as asymmetrically heated open cracks in rocks. They can host molecular evolution by an unexpected combination of molecular, thermal and fluidic effects. For example, intricate wet-dry cycles are created at fuild-gas interfaces in a thermal gradient. Also, the temperature difference induces laminar convection which thermocycles genetic molecules for replication. At the same time, polymerization and accumulation is mutually enhanced in a hyperexponential fashion. The setting also lead to physical selection of cooperating, complexing molecules from a continuous feeding flow. In the past, we clarified the microscopic physics behind the motion of molecules in a temperature difference, studied the nonequilibrium physics of pH gradients, have established methods to driven microfluidics by light and have studied reaction kinetics in living cells all-optically.

近期论文

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Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules M. Morasch, J. Liu, C.F. Dirscherl, A. Ianeselli, A. Kühnlein, K. Le Vay, P. Schwintek, S. Islam, M.K. Corpinot, B. Scheu, D.B. Dingwell, P. Schwille, H. Mutschler, M.W. Powner, C.B. Mast & D. Braun Nature Chemistry (2019), doi.org/10.1038/s41557-019-0299-5 Periodic Melting of Oligonucleotides by Oscillating Salt Concentrations triggered by Microscale Water Cycles inside Heated Rock Pores Alan Ianeselli, Christof B. Mast and Dieter Braun Angewandte Chemie (2019), doi.org/10.1002/ange.201907909 Cooperative ligation breaks sequence symmetry and stabilizes early molecular replication Shoichi Toyabe and Dieter Braun Physical Review X 9, 011056 Continuous nonenzymatic cross-replication of DNA strands with in situ activated DNA oligonucleotides Evgeniia Edeleva, Annalena Salditt, Julian Stamp, Philipp Schwintek, Job Boekhoven and Dieter Braun Chemical Science 10, 5807 - 5814, doi:10.1039/C9SC00770A (2019) Optochemical disequilibrium to measure biomolecule charge Friederike M. Möller, Michael Kieß, Christof Mast and Dieter Braun Physical Review E 98, 062601 (2018) doi.org/10.1103/PhysRevE.98.062601 Proton Gradient and pH oscillations emerge from heat flow at the microscale Lorenz Keil, Friederike Möller, Michael Kieß, Patrick Kudella and Christof Mast Nature Communication 8, 1897 (2017) doi:10.1038/s41467-017-02065-3 Reversible Switching of Cooperating Replicators Georg C. Urtel, Thomas Rind and Dieter Braun Phys. Rev. Lett. 118, 078102 (2017)doi: 10.1103/PhysRevLett.118.078102 Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis T. Dau, E. V. Edeleva, S. A. I. Seidel, R. A. Stockley, Dieter Braun & D. E. Jenne Scientific Reports (2016) doi: 10.1038/srep35413 Probing of molecular replication and accumulation in shallow heat gradients through numerical simulations Lorenz Keil, Michael Hartmann, Simon Lanzmich and Dieter Braun PCCP (2016) doi: 10.1039/C6CP00577B Photochemical microscale electrophoresis allows fast quantification of biomolecule binding Friederike M. Möller, Michael Kieß, Dieter Braun JACS (2016) doi: 10.1021/jacs.6b01756 Heat-Flow-Driven Oligonucleotide Gelation Separates Single-Base Differences Matthias Morasch, Dieter Braun, and Christof B. Mast Angewandte Chemie (2016) doi: 10.1002/anie.201603779 Quantitative thermophoretic study of disease-related protein aggregates Manuel Wolff, Judith Mittag, Therese Herling, Erwin De Genst, Christopher Dobson, Tuomas Knowles, Dieter Braun, Alexander Buell Scientific Reports (2016) doi:10.1038/srep22829 Single molecule imaging in living Drosophila embryos with reflected light-sheet microscopy Ferdinand Greiss, Myrto Deligiannaki, Christophe Jung, Ulrike Gaul, Dieter Braun Biophysical Journal (2016) doi 10.1016/j.bpj.2015.12.035 hermooptical molecule sieve on the microscale Natan Osterman and Dieter Braun Applied Physics Letters (2015) doi 10.1063/1.4907357 Understanding the similarity in thermophoresis between single- and double-stranded DNA or RNA Maren Reichl, Mario Herzog, Ferdinand Greiss, Manuel Wolff, and Dieter Braun Physical Review E 91,062709 (2015), doi:10.1103/PhysRevE.91.062709 Heat flux across an open pore enables the continuous replication and selection of oligonucleotides towards increasing length Moritz Kreysing, Lorenz Keil, Simon Lanzmich and Dieter Braun Nature Chemistry (2015) doi:10.1038/nchem.2155 Thermophoretic Manipulation of Molecules Inside Living Cells Maren R. Reichl and Dieter Braun JACS 136, 15955–15960 (2014) doi:10.1021/ja506169b Article on Phys.org