Panchenko, Maria V. - Boston University

研究领域

Our lab is interested in the area of epithelial cell biology and homeostasis in mammals. A single layer of epithelial cells lining tubules are found in several organs and serve protective and active functions. Thus, the differentiated epithelial cells are known to mediate a number of functions, including transmembrane transport, filtration and secretion in and out of the lumen. An interesting feature of epithelial cells is that they are able to de-differentiate and enter the cell cycle which is important for the maintenance of the lining, or proliferate after an injury to replenish for the lost cells and aid in organ regeneration (kidney tubular epithelia). Epithelial cell progenitors and stem cells such as those found in the bottom of colon crypts, divide to provide continuous renewal of differentiated columnar epithelial lining. The rates of epithelial cells turnover varies and depends on their specific function in a given organ. The regulation of the cell cycle is crucial for the homeostasis and regeneration of epithelia in vivo. Accurate replication, segregation, and orientation of chromatin ensure genetic integrity and represent most important events during the epithelial cell division. Errors may result in either insufficient regeneration (degenerative pathology) or excessive uncontrolled proliferation (cancer). We are specifically interested in factors that sense and directly link chromatin integrity with the cell division, which is an exciting area of epithelial cell biology and is highly relevant to human diseases. We use in vitro cell culture models, transgenic mice models, and human specimens to discover and validate factors that interact with chromatin and control cell cycle progression.

近期论文

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Nolin A, Mulhern R, Panchenko M, Pisarek-Horowitz A, Wang Z, Shirihai O, Borkan S, and Havasi A. 2016. Proteinuria causes dysfunctional autophagy in the proximal tubule. American Journal of Physiology (accepted) Panchenko MV. 2016. Structure, function and regulation of Jade Family PHD Finger 1 (JADE1) GENE 589(1):1-11 PMID: 27155521 Siriwardana, NS, Meyer RD, and Panchenko MV* (2015): The novel function of JADE1S protein in cytokinesis of epithelial cells. Cell Cycle 14:2821-2834 PMID: 26151225 * Comment in Cell Cycle by Prekeris R (2015): Cut or NoCut: the Role of JADE1S in Regulating Abscission Checkpoint Cell Cycle Siriwardana NS, Meyer R, Havasi R, Dominguez I, and Panchenko MV* (2014): Cell cycle-dependent Chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex. Cell Cycle Jun 15;13(12):1885-901 PMID: 24739512 *Comment in Cell Cycle by Calvi BR (2014): HBO1:JADE1 at the cell cycle chromatin crossroads. Havasi, A., J. A. Haegele, J. M. Gall, S. Blackmon, T. Ichimura, R. G. Bonegio, and M. V. Panchenko. Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration. Am J Pathol 152-162. Foy, R. L., V. C. Chitalia, M. V. Panchenko, L. Zeng, D. Lopez, J. W. Lee, S. V. Rana, A. Boletta, F. Qian, L. Tsiokas, K. B. Piontek, G. G. Germino, M. I. Zhou, and H. T. Cohen. 2012. Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum Mol Genet 5456-5471. Foy, R. L., I. Y. Song, V. C. Chitalia, H. T. Cohen, N. Saksouk, C. Cayrou, C. Vaziri, J. Cote, and M. V. Panchenko. 2008. Role of Jade1 in the histone acetyltransferase (HAT) HBO1 complex. J Biol Chem 283:28817-28826. Chitalia, V. C., R. L. Foy, M. M. Bachschmid, L. Zeng, M. V. Panchenko, M. I. Zhou, A. Bharti, D. C. Seldin, S. H. Lecker, I. Dominguez, and H. T. Cohen. 2008. Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. Nat Cell Biol 1208-1216. DiCamillo, S. J., S. Yang, M. V. Panchenko, P. A. Toselli, E. F. Naggar, C. B. Rich, P. J. Stone, M. A. Nugent, and M. P. Panchenko. 2006. Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts. Am J Physiol Lung Cell Mol Physiol L232-243. Zhou, M. I., R. L. Foy, V. C. Chitalia, J. Zhao, M. V. Panchenko, H. Wang, and H. T. Cohen. 2005. Jade-1, a candidate renal tumor suppressor that promotes apoptosis. Proc Natl Acad Sci U S A 11035-11040. Panchenko, M. V., M. I. Zhou, and H. T. Cohen. 2004. von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity. J Biol Chem 56032-56041. DiCamillo, S. J., I. Carreras, M. V. Panchenko, P. J. Stone, M. A. Nugent, J. A. Foster, and M. P. Panchenko. 2002. Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down- regulate tropoelastin mRNA in lung fibroblasts. J Biol Chem 18938-18946. Panchenko, M. V., H. W. Farber, and J. H. Korn. 2000. Induction of heme oxygenase-1 by hypoxia and free radicals in human dermal fibroblasts. Am J Physiol Cell Physiol C92-C101. Panchenko, M. V., W. G. Stetler-Stevenson, O. V. Trubetskoy, S. N. Gacheru, and H. M. Kagan. 1996. Metalloproteinase activity secreted by fibrogenic cells in the processing of prolysyl oxidase. Potential role of procollagen C-proteinase. J Biol Chem 7113-7119. Graven, K. K., R. F. Troxler, H. Kornfeld, M. V. Panchenko, and H. W. Farber. 1994. Regulation of endothelial cell glyceraldehyde-3-phosphate dehydrogenase expression by hypoxia. J Biol Chem 24446-24453. Kagan, H. M., V. B. Reddy, M. V. Panchenko, N. Nagan, A. M. Boak, S. N. Gacheru, and K. M. Thomas. 1995. Expression of lysyl oxidase from cDNA constructs in mammalian cells: the propeptide region is not essential to the folding and secretion of the functional enzyme. Journal of Cellular Biochemistry 329-338.