Browning, Jeffrey L. - Boston University

个人简介

Jeff Browning did his PhD training in the Biochemistry Department of the University of Wisconsin with two further postdoctoral studies in lipid membrane structure and solid state NMR in the Biophysics Department in the Biozentrum of the University of Basel and in neurobiology at the University of California, San Francisco. He joined the biotechnology firm Biogen in 1984 as a research scientist in the Immunobiology Department studying TNF family members. In 2012, he moved to the Department of Microbiology of Boston University School of Medicine and holds an adjunct appointment in the Rheumatology Section.

研究领域

My focus centers on understanding how the immune system interacts with stromal elements to form the specialized reticular fibroblastic networks orchestrating cell-cell encounters in lymphoid organs. Fibroblasts can be found in many different states ranging from basic dermal fibroblasts to perivascular adventitial fibroblasts to the highly specialized reticular networks found in lymphoid tissues. We are currently trying to create a “guidebook” to these states as they occur in vivo as well as assessing the in vitro counterparts of the various differentiation stages. A major emphasis is on the states of these cells in human diseases and, to this end, we primarily study skin biopsies from scleroderma and lupus patients as well as the various lymphoid organs. Our goal is to provide a better understanding of these stages allowing insight into the conversion to the fibrotic state in scleroderma as well as the key events that lead to lymphocyte retention in the perivascular compartment. Such knowledge should lead to novel approaches to pharmacological intervention in autoimmune diseases and oncology.

近期论文

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Grzegorzewska AP, Seta F, Han R, Czajka CA, Stawski L, Isenberg JS, Browning JL, and M Trojanowska. 2017. Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways, Science Reports in press Nazari, B, Rice LM, Stifano G, Barron A, Wong YM, Lee J, Korndorf T, Bhawan J, Lafyatis R and JL Browning. 2016. A Pan-Dermal Fibroblast Transition in Systemic Sclerosis Skin. Am. J. Pathol. 186:2650-2664. PMID: 27565038 Gardet A, Chou WC, Reynolds TL, Velez DB, Fu K, Czerkowicz JM, Bajko J, Ranger AM, Allaire N, Kerns HM, Ryan S, Legault HM, Dunstan RW, Lafyatis R, Lukashev M, Viney JL, Browning JL, and D Rabah. 2016. Pristane-Accelerated Autoimmune Disease in (SWR X NZB) F1 Mice Leads to Prominent Tubulointerstitial Inflammation and Human Lupus Nephritis-Like Fibrosis. PLoS One e0164423. PMID: 27760209 Seleznik G, Seeger, H, J. Bauer J, Fu K, Czerkowicz J, Papandile A, Poreci U, Rabah D, Ranger A, Cohen CD, Lindenmeyer M, Chen J, Edenhofer I, Anders H-J, Lech M, Wüthrich RP, Ruddle NH, Moeller MJ, Kozakowski N, Regele H, Browning JL, Heikenwalder M, and S Segerer. 2015. The Lymphotoxin β receptor is a potential therapeutic target in renal inflammation. Kidney Int. 89:113-126. PMID: 26398497 Lu, T and Browning, JL. 2014. Role of the Lymphotoxin/LIGHT system in in the Development and Maintenance of Reticular Networks and Vasculature in Lymphoid Tissues. Front. Immunol. 5: 47. PMID: 24575096 Beinkowska, J, Goyal, J, Plavina, T, Allaire, N, Thai, A, Ranger, A, Nirula, A, O’Gorman, J, Weaver, M, Newman, C, Petri, M, Beckman, E and JL Browning. 2014. Lymphotoxin-LIGHT Pathway Regulates the Interferon Signature in Rheumatoid Arthritis. PloS One 9:e112545. PMID: 255405351 Crowe, P.D., VanArsdale, T.L., Walter, B.N., Ware, C.F., Hession, C., Ehrenfels, B., Browning, J.L., Din, W., Goodwin, R.G. and C.A. Smith 2014. Pillars article: A lymphotoxin-B-specific receptor. Science. 1994. 264: 707-710. J Immunol 192: 2015-2018. PMID: 24563505 Gommerman JL, Browning JL, and CF Ware. 2014. The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity. Cytokine Growth Factor Rev. 25:139-145. PMID: 24698108 Edwards, KR, Goyal, Plavina, T, Kujawa, J, Goelz, S, Ranger, A, Diego Cadavid, D and JL Browning. 2013. Feasibility of the Use of Combinatorial Chemokine Arrays to Study Blood and CSF in MS. PLoS One 8:e81007. PMID: 24278364 Browning JL. 2012 Lymphotoxin and the amazing technicolor circus of intestinal homeostasis. Mucosal Immunol. 5:228-231. PMID: 22318496 McCarthy, DD, Kujawa, J, Wilson, C, Papandile, A, Poreci, U, Ward, L, Lawson, M, Macpherson, AJ, McCoy, K, Pei, Y, Julian, B, Novak, J, Ranger, A, Gommerman, JL, and JL Browning. 2011. Mice Over-expressing BAFF Develop a Commensal Flora-Dependent, IgA-Associated Nephropathy. J. Clin. Invest. 121:3991-4002. PMID: 21881212 Fava RA, Kennedy SM, Wood SG, Bolstad AI, Bienkowska J, Papandile P, Kelly JA, Mavragani CP, Gatumu M, Skarstein K, Hitchmoth DL and JL Browning. 2011. Lymphotoxin-beta Receptor Blockade Reduces CXCL13 in Lacrimal Glands and Improves Tear Secretion and Corneal Integrity in the NOD Model of Sjögren’s Syndrome. Arthritis Res. Ther. 13:R182. PMID: 22044682