Siggers, Trevor W. - Boston University

研究领域

systems biology of the immune and inflammatory systems, gene regulation in immune and inflammatory systems, inflammatory diseases, transcriptional networks, DNA-binding of transcription factors and transcriptional regulatory complexes, computational genomics, cis-regulatory logic in transcription

近期论文

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Siggers T*, Chang AB*, Teixeira A, Wong D, Williams KJ, Ahmed B, Ragoussis J, Udalova IA, Smale ST, Bulyk ML. (2012). Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding. Nature Immunology 13(1):95-102 Siggers T, Duyzend MH, Reddy J, Khan S, Bulyk ML. (2011). Non-DNA-binding cofactors enhance DNA-binding specificity of a transcriptional regulatory complex. Molecular Systems Biology 7:555 Wong D, Teixeira A, Oikonomopoulos S, Humburg P, Lone IN, Saliba D, Siggers T, Bulyk ML, Angelov D, Dimitrov S, Udalova I, Ragoussis J. (2011). Extensive characterization of NF-KappaB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits. Genome Biol. 12(7):R70 Rowan S*, Siggers T*, Lachke SA, Yue Y, Bulyk ML, Maas RL. (2010). Precise temporal control of the eye regulatory gene Pax6 via enhancer binding site affinity. Genes Dev. 24(10):980-985. Giorgetti L, Siggers T, Tiana G, Caprara G, Notarbartolo S, Corona T, Pasparakis M, Milani P, Bulyk ML, Natoli G. (2010). Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses transcriptional responses to environmental inputs. Mol. Cell. 37(3):418-428. Viiri KM, Janis J, Siggers T, Heinonen TY, Valjakka J, Bulyk ML, Maki M, Lohi O. (2009). DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides. Mol. Cell Biol. 29:342-356. Siggers T, Honig B. (2007). Structure-based prediction of C2H2 zinc-finger binding specificity: sensitivity to docking geometry. Nucleic Acids Res. 35(5):1085-1097. Siggers T, Silkov A, Honig B. (2005). Structural alignment of protein-DNA interfaces: insights into the determinants of binding specificity. JMB 345(5):1027-1045.