Man, Hengye - Boston University - Department of Biology

研究领域

Brain development, neuron morphogenesis, synapse formation, synaptic plasticity, AMPA type glutamate receptor, protein ubiquitination and degradation, autism, Intellectual disability, Alzheimer’s disease

近期论文

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Gilbert J, Shu S, Yang X, Lu Y M, Zhu L Q and Man HY (2016) β-amyloid triggers aberrant over-scaling of homoeostatic synaptic plasticity. Acta Neuropathol Commun. 2016 Dec 13; 4(1):1 Gilbert J and Man H Y (2016) The X-linked autism protein KIAA2022/KIDLIA regulates neurite outgrowth via N-cadherin and δ-catenin signaling. eNeuro, Oct 2016 DOI: 10.1523/ENEURO.0238-16.2016. Hou Q, Ruan H, Gilbert J, Wang G, Ma Q, Yao WD, Man HY (2015) MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity. Nature Communication DOI: 10.1038. Van Maldergem L, Hou Q, Kalscheuer VM, Rio M, Doco-Fenzy M, Medeira A, de Brouwer AP, Cabrol C, Haas SA, Cacciagli P, Moutton S, Landais E, Motte J, Colleaux L, Bonnet C, Villard L, Dupont J, Man HY (2013) Loss of function of KIAA2022 causes mild to severe intellectual disability with an autism spectrum disorder and impairs neurite outgrowth. Human Molecular Genetics, 22(16): 3306-3314. Qingming H, Gilbert J, Man HY (2011) Homeostatic regulation of AMPA receptor trafficking and degradation by light-controlled single-synaptic activation. Neuron, 72 (5), 806-818. S Amato S, Liu X, Zheng B, Cantley L, Rakic P, Man HY (2011) AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization. Science, 332(6026):247-51. Lin A, Hou Q, Jarzylo L, Amato S, Gilbert J, Shang F, Man HY (2011) Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking. J. Neurochemistry, 117 (5), 614-625. Zhang D, Hou Q, Wang M, Lin A, Navis A, Raissi A, Liu F, Man HY (2009) Na, K-ATPase activity regulates AMPA receptor turnover through proteasome-mediated proteolysis. J Neurosci., 29 (14): 4498-4511.