Loechler, Edward L. - Boston University

研究领域

molecular biology; mechanisms by which carcinogens cause mutations and cancer

近期论文

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Chandani S, Loechler EL (2013) “Structural model of the y-family DNA polymerase V/RecA mutasome”Journal of Molecular Graphics and Modelling. 39, 133 – 144. Chandani S, Jacobs C, Loechler EL (2010) Architecture of y-family DNA polymerases relevant to translesion DNA synthesis as revealed in structural and molecular modeling studies. Journal of Nucleic Acids. pii: 784081. Chandani S, Loechler EL (2010) Translesion synthesis and mutagenic pathways in E. coli cells. The Chemical Biology of DNA Damage, Wiley-VCH, Weinheim, Germany, pp. 353-380. Chandani S, Loechler EL (2009) Y-family DNA polymerases may use two different dNTP shapes for insertion: A hypothesis and its implications Journal of Molecular Graphics and Modelling. 27, 759 – 769. Seo K-Y, Yin J, Donthamsetti P, Chandani S, Lee CH, Loechler EL (2009) Amino acid architecture that influences dNTP insertion efficiency in Y-family DNA polymerase V of E. coli. Journal of Molecular Biology. 392, 270 – 282. Clapp RW, Jacobs MW, Loechler EL (2008) Environmental and occupational causes of cancer: new evidence 2005 – 2007. Rev. Env. Health 23, 1-37. Chandani S, Lee CH, Loechler EL (2007) Molecular modeling benzo[a]pyrene N2-dG adducts in two partially overlapping active sites of the y-family DNA polymerase Dpo4. Journal of Molecular Graphics and Modelling. 25, 658-670. Seo K -Y, Nagalingam A, Miri S, Yin J, Kolbanovskiy A, Shastry A, Loechler EL (2006) Mirror image stereoisomers of the major benzo[a]pyrene N2-dG adduct are bypassed by different lesion-bypass DNA polymerases in E. coli. DNA Repair 5, 515-527.