研究领域
Molecular and cellular basis of synaptic function in neurodevelopment and neurodegenerative disease
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Dillon GM, Tyler WA, Omuro KC, Kambouris J, Tyminski C, Henry S, Haydar TF, Beffert U, Ho A (2017) CLASP2 links reelin to the cytoskeleton during neocortical development. Neuron 93, 1344-1358, March 22, 2017. PMID: 28285824.
Sullivan SE, Dillon GM, Sullivan JM, Ho A (2014) Mint proteins are required for synaptic activity-dependent APP trafficking and amyloid-beta generation. Journal of Biological Chemistry, 289: 15374-15383.
Beffert U, Dillon GM, Sullivan JM, Stuart CE, Gilbert JP, Kambouris JA, Ho A (2012) Microtubule plus-end tracking protein CLASP2 regulates neuronal polarity and synaptic function. Journal of Neuroscience, 32: 13906-13916.
Chaufty J, Sullivan SE, Ho A (2012) Intracellular APP sorting and Aß secretion are regulated by src-mediated phosphorylation of Mint2. Journal of Neuroscience, 32: 9613-9625.
Matos MF, Xu Y, Dulubova I, Otwinowski Z, Richardson III JM, Tomchick DR, Rizo J, Ho A (2012) Autoinhibition of Mint1 adaptor protein regulates APP binding and processing. Proceedings National Academy Sciences USA 109: 3802-3807.
Ho A and Shen J (2011) Presenilins in synaptic function and disease. Trends in Molecular Medicine 17: 617-624.
Ho A, Liu X, Südhof TC (2008) Deletion of mint proteins decreases amyloid production in transgenic mouse models of Alzheimer’s disease. Journal of Neuroscience 28: 14392-14400.
Ho A, Morishita W, Atasoy D, Liu X, Tabuchi K, Hammer RE, Malenka RC, Südhof TC (2006) Genetic analysis of Mint/X11 proteins: Essential presynaptic functions of a neuronal adaptor protein family. Journal of Neuroscience 26: 13089-13101.
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