Cheng, Christine - Boston University

研究领域

systems biology, single-cell functional genomics, epigenetic and transcriptional regulation, immune regulation, translational research, inflammation, bioinformatics

近期论文

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Cheng CS*, Gate RE*, Aiden AP, Siba A, Tabaka M, Lituiev D, Machol I, Subramaniam M, Shamim M, Hougen KL, Wortman I, Huan SC, Durand NC, Feng T, De Jager PL, Chang HY, Aiden EL, Benoist C, Beer MA, Ye CJ§, Regev A§. Genetic determinants of chromatin accessibility and gene regulation in T cell activation across human individuals. Submitted to Science, in review. (* Equal contribution; § corresponding authors) Link Cheng CS*, Behar MS*, Suryawanish GW, Feldman KE, Spreafico R, Hoffmann A. Iterative modeling reveals evidence of sequential transcriptional control mechanisms. Cell Systems, 2017 Feb 10. pii: S2405-4712(17)30012-1. (* Equal contribution) Sanjana NE, Wright J, Zheng K, Shalem O, Fontanillas P, Joung J, Cheng CS, Regev A, Zhang F. High-throughput dissection of the human noncoding genome. Science, 2016 Sep 30;353(6307): 1545-1549. PMID: 27708104 Cheng CS, Rai K, Garber M, Hollinger A, Robbins D, Anderson S, Macbeth A, Tzou A, Carneiro MO, Raychowdhury R, Russ C, Hacohen N, Gershenwald JE, Lennon N, Nusbaum C, Chin L, Regev A, Amit I. Semiconductor-based DNA sequencing of histone modification states. Nature Communications. 2013;4:2672. PMCID: PMC3917140 Garber M, Yosef N, Goren A, Raychowdhury R, Thielke A, Guttman M, Robinson J, Minie B, Chevrier N, Itzhaki Z, Blecher-Gonen R, Bornstein C, Amann-Zalcenstein D, Weiner A, Friedrich D, Meldrim J, Ram O, Cheng C, Gnirke A, Fisher S, Friedman N, Wong B, Bernstein BE, Nusbaum C, Hacohen N, Regev A, Amit I. A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol Cell. 2012 Sep 14;47(5):810-22. PMCID: PMC3873101 Cheng CS, Feldman KE, Lee J, Verma S, Huang DB, Huynh K, Chang M, Ponomarenko JC, Sun SC, Benedict CA, Ghosh G, Hoffmann A. The specificity of innate immune responses is enforced by repression of interferon response elements by NFkB p50. Science Signaling. 2011 Feb 22;4(161):ra11. PMCID: PMC3096068 Escoubet-Lozach L, Benner C, Kaikkonen MU, Lozach J, Heinz S, Spann NJ, Crotti A, Stender J, Ghisletti S, Reichart D, Cheng CS, Luna R, Ludka C, Sasik R, Garcia-Bassets I, Hoffmann A, Subramaniam S, Hardiman G, Rosenfeld MG, Glass CK. Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet. 2011 Dec;7(12):e1002401. PMCID: PMC3234212 Ramirez-Carrozzi VR, Braas D, Bhatt DM, Cheng CS, Hong C, Doty KR, Black JC, Hoffmann A, Carey M, Smale ST. A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell. 2009 Jul 10;138(1):114-28. PMCID: PMC2712736