Hoffman, Charles - Boston College - Department of Biology

研究领域

Use of the fission yeast Schizosaccharomyces pombe for chemical genetic study of cyclic nucleotide phosphodiesterases (PDEs) and other cAMP pathway components from mammals and pathogens.

近期论文

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Fantes P.A. and Hoffman C.S. (2016). A Brief History of Schizosaccharomyces pombe Research: A Perspective Over the Past 70 Years. Genetics, 203:621-9. doi: 10.1534/genetics.116.189407 Takemata N, Oda A, Yamada T, Galipon J, Miyoshi T, Suzuki Y, Sugano S, Hoffman CS, Hirota K, Ohta K. (2016). Local potentiation of stress-responsive genes by upstream noncoding transcription. Nucleic Acids Res. 44:5174-89. doi: 10.1093/nar/gkw142 Xu C, Wyman AR, Alaamery MA, Argueta SA, Ivey FD, Meyers JA, Lerner A, Burdo TH, Connolly T, Hoffman CS, Chiles TC. (2016). Anti-inflammatory effects of novel barbituric acid derivatives in T lymphocytes. Int Immunopharmacol. 2016 Sep;38:223-32. doi: 10.1016/j.intimp.2016.06.004 Hoffman, C.S., Wood, V. and Fantes P.A (2015) An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System Genetics. 2015 Oct;201(2):403-23. doi: 10.1534/genetics.115.181503. de Medeiros A.S. and Hoffman C.S. (2015) A yeast-based high-throughput screen for modulators of phosphodiesterase activity. Methods Mol Biol. 2015;1294:181-90. doi: 10.1007/978-1-4939-2537-7_14. de Medeiros A.S., Kwak G., Vanderhooft J., Rivera S., Gottlieb R., and Hoffman C.S. (2015) Fission Yeast-Based High-Throughput Screens for PKA Pathway Inhibitors and Activators. Methods Mol Biol.1263:77-91. doi: 10.1007/978-1-4939-2269-7_6. Asada R, Takemata N, Hoffman CS, Ohta K, Hirota K. (2014) Antagonistic controls of chromatin and mRNA start site selection by Tup family corepressors and the CCAAT-binding factor Mol Cell Biol. pii: MCB.00924-14. [Epub ahead of print] PMID:25535331 Mudge D.K., Yang F., Currie B.M., Kim J.M., Yeda K., Bashyakarla V.K., Ivey F.D., and Hoffman C.S. (2014). Sck1 negatively-regulates Gpa2-mediated glucose signaling in Schizosaccharomyces pombe. Eukaryot Cell. 2014 Feb;13(2):202-8. doi: 10.1128/EC.00277-13. Demirbas, D., Wyman, A.R., Shimizu-Albergine, M., Cakici, O., Beavo, J.A., and Hoffman, C.S. (2013). A Yeast-Based High-Throughput Screen Identifies A Phosphodiesterase Inhibitor That Elevates Steroidogenesis In Mouse Leydig Cells Via PDE8 And PDE4 Inhibition. PLoS One. 2013;8(8):e71279. doi: 10.1371/journal.pone.0071279. de Medeiros, A.S., Magee, A., Nelson, K., Friedberg, L., Trocka, K., and Hoffman, C.S. (2013). Use of PKA-mediated phenotypes for genetic and small molecule screens in Schizosaccharomyces pombe. Biochem Soc Trans. 2013 Dec 1;41(6):1692-5. doi: 10.1042/BST20130159. Ceyhan O., Birsoy K., and Hoffman C.S. 2012. Identification of biologically active PDE11-selective inhibitors using a yeast-based high throughput screen, Chemistry & Biology, 19:155-163. Mudge D.K., Hoffman C.A., Lubinski T.J., and Hoffman C.S. 2012. Use of a ura5+-lys7+ cassette to construct unmarked gene knock-ins in Schizosaccharomyces pombe, Current Genetics, 58: 59-64. Didem Demirbas, Ozge Ceyhan, Arlene R. Wyman and Charles S. Hoffman 2011. A Fission Yeast-based Platform for Phosphodiesterase Inhibitor HTSs and Analyses of Phosphodiesterase Activity, Handbook of Experimental Pharmacology (Houslay, Francis, and Conti eds.) Phosphodiesterases as Drug Targets 2011 (204): 135-149. Demirbas, D., Ceyhan, O., Wyman, A.R., Ivey, F.D., Allain, C., Wang, L., Sharuk, M.N., Francis, S.H., and Hoffman, C.S. 2011. Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP-metabolising phosphodiesterases. Cellular Signalling. 23(3):594-601. PubMed Ivey, F.D., Taglia, F.X., Yang, F., Lander, M.M., Kelly, D.A., and Hoffman, C.S. 2010. Activated alleles of the Schizosaccharomyces pombe gpa2+ Gα gene identify residues involved in GDP-GTP exchange. Eukaryotic Cell 9: 626–633. PubMed Alaamery, M.A., Wyman, A.R., Ivey, F.D., Allain, C., Demirbas, D., Wang, L., Ceyhan, O., and Hoffman, C.S. 2010. New classes of PDE7 inhibitors identified by a fission yeast-based HTS. Journal of Biomolecular Screening 15:359–367. PubMed Roux, A.E., Leroux, A., Alaamery, M.A., Hoffman, C.S., Chartrand, P., Ferbeyre, G., and Rokeach, L.A. 2009. Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast. PLoS Genetics 5(3): e1000408. PubMed Hirota, K., Miyoshi, T., Kugou, K., Hoffman, C.S., Shibata, T., and Ohta, K. 2008. Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs. Nature 456: 130–134. PubMed Leem, Y.-E., Ripmaster, T., Kelly, F., Ebina, H., Heincelman, M., Zhang, K., Grewal, S.I.S., Hoffman, C. S., and Levin, H. L. 2008. The pol II promoters of Schizosaccharomyces pombe are targeted by an LTR retrotransposon that is capable of repairing the promoters it disrupts. Molecular Cell 30: 98–107. PubMed Alaamery, M.A., and Hoffman, C.S. 2008. Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling. Genetics 178: 1927–36. Ivey, F.D., Wang, L., Demirbas, D., Allain, C., Hoffman, C.S. 2008. Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases. Journal of Biomolecular Screening 13: 62–71. PubMed Hoffman, C.S. 2007. Propping up our knowledge of G protein signaling pathways: diverse functions of putative noncanonical Gbeta subunits in fungi. Science's STKE 370: 3. PubMed Kao, R.S., Morreale, E., Wang, L., Ivey, F.D., Hoffman, C.S. 2006. Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase. Genetics 173: 49–61. PubMed Hoffman, R.L., and Hoffman, C.S. 2006. Cloning the Schizosaccharomyces pombe lys2+ gene and construction of new molecular genetic tools. Current Genetics 49: 414–420. PubMedWang, L., Griffiths, K., Zhang, Y.H., Ivey, F.D., Hoffman, C.S. 2005. Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling. Genetics 171: 1523–1533. PubMed