Gubbels, Marc-Jan - Boston College - Department of Biology

研究领域

Genetic approaches towards the cell biology of Toxoplasma gondii.

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Paul, A.S., S., Saha, K. Engelberg, R.Y. Jiang, B.I. Coleman, A.L. Kosber, C.-T. Chen, M. Ganter, N. Espy, T.-W. Gilberger, M.-J. Gubbels*, and M.T. Duraisingh*. Apicomplexan calcineurin regulates specific attachment of free parasites to host cells for infection. Cell Host Microbe. in press. *co-corresponding author Blader, I.J., B.I. Coleman, C.-T. Chen, and M.-J. Gubbels. 2015. The Toxoplasma gondii lytic cycle. Ann. Rev. Microbiol. in press (invited review) Chen, C.-T., and M.-J. Gubbels. 2015. Apicomplexan cell cycle flexibility: centrosome controls the clutch. Trends Parasitol. 31:229-230 Brown, K.M. E. Suvorova, A. Farrell, A. McLain, A. Dittmar, G.B. Wiley, G.T. Marth, P.M. Gaffney, M.-J. Gubbels, M. White, and I. Blader. 2014. Forward genetic screening identifies a small molecule that blocks Toxoplasma growth by inhibiting both host- and parasite-encoded kinases. PLoS Path. 10(6):e1004180. Farrell, A., B.I. Coleman, B. Benenati, K.M. Brown, I. Blader, G.T. Marth, and M.-J. Gubbels. 2014. Whole genome profiling of spontaneous and chemical mutagenesis induced mutations in Toxoplasma gondii. BMC Genomics. 15: 354. Gubbels, M.-J., and Morrissette, N. 2013. The Cytoskeleton: structures and motility (chapter 13). In: Toxoplasma gondii: The Model Apicomplexan, 2nd edition. Eds.: L.M. Weiss and K. Kim. Elsevier Academic Press. ISBN: 9780123964816. Farrell, M., and M.-J. Gubbels. 2014. The Toxoplasma gondii kinetochore is required for centrosome association with the centrocone (spindle pole). Cell. Microbiol. 16: 78-94. Morlon-Guyot, J., L. Berry, C.-T. Chen, M.-J. Gubbels, M. Lebrun, and W. Daher. 2014. The Toxoplasma gondii Calcium Dependent Protein Kinase 7 is involved in early steps of parasite division and is crucial for parasite survival. Cell. Microbiol. 16: 95-114. Yang, N., A. Farrell, W. Niedelman, M. Melo, D. Lu, L. Julien, G.T. Marth, M.-J. Gubbels, J.P.J. Saeij. 2013 Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains. BMC Genomics. 14:467. Chen, C.-T. and M.-J. Gubbels. 2013. The Toxoplasma gondii centrosome is the platform for internal daughter budding as revealed by a Nek1 kinase mutant. Journal of Cell Science. 126:3344-3355. Lorestani, A., F.D. Ivey, S. Thirugnanam, M.A. Busby, G.T. Marth, I. Cheeseman, and M.-J. Gubbels. 2012. Targeted proteomic dissection of Toxoplasma cytoskeleton sub-compartments using MORN1. Cytoskeleton. 69:1069-1085. Gubbels, M.-J. and M.T. Durasingh. 2012. Evolution of apicomplexan secretory organelles. Int. J. Parasitol. 42:1071-1081 (invited review). Highlighted as a Feature Article on the Malaria Nexus website. Bushkin, G.G., P. Magnelli, E. Motari, M.-J. Gubbels, J.P. Dubey, K. Miska, E. Bullitt, C.E. Costello, P.W. Robbins, and J. Samuelson. 2012. β-1,3-glucan, a druggable target, is part of a trabecular scaffold in inner layer of the oocyst wall of Toxoplasma and Eimeria. mBio. 3(5). pii: e00258-12. Anderson-White, B.R., J.R. Beck, C.-T. Chen, M. Meissner, P.J. Bradley, and M.-J. Gubbels. 2012. Cytoskeleton assembly in Toxoplasma gondii cell division. Int. Rev. Cell Mol. Biol. 298:1-31. Fung, C., J.R. Beck, S.D. Robertson, M.-J. Gubbels, and P.J. Bradley. Toxoplasma ISP4 is a central IMC sub-compartment protein whose localization depends on palmitoylation but not myristoylation. Mol. Biochem Parasitol. 184:99-108. Szatanek, T., B.R. Anderson-White, M. White, J. Saeij, and M.-J. Gubbels. 2012. Cactin is essential for G1 progression in Toxoplasma gondii. Mol. Micro. 84:566-577. Coleman, B.I., and M.-J. Gubbels. 2012. A genetic screen to isolate Toxoplasma gondii host cell egress mutants. J. Vis. Exp. 60:e3807. Farrell, A. S. Thirugnanam, A. Lorestani, J.D. Dvorin, K.P. Eidell, B.R. Anderson-White, D.J.P. Ferguson, M.T. Duraisingh, G.T. Marth, and M.-J. Gubbels. 2012. A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis. Science. 335:218-221. Jammallo*, L., K. Eidell*, P.H. Davis, F.J. Dufort, C. Cronin, S. Thirugnanam, T.C. Chiles, D.S. Roos, and M.-J. Gubbels. 2011. An insertional trap for conditional gene expression in Toxoplasma gondii: identification of TAF250 as an essential gene. Mol. Biochem. Parasitol. 175:133-143. (*equal contribution). Anderson-White, B.R., Ivey, F.D., Cheng, K. K., Szatanek, T., Lorestani, A., Beckers, C.J., Ferguson, D.J.P., Sahoo, N., and Gubbels, M.-J. 2010. A family of intermediate filament-like proteins is sequentially assembled into the cytoskeletal scaffold of Toxoplasma gondii. Cellular Microbiology 13:18-31. Lorestani, A., L. Sheiner, K. Yang, S.D. Robertson, N. Sahoo, C.F. Brooks, D.P.J. Ferguson, B. Striepen, and M.-J. Gubbels. 2010. A Toxoplasma MORN1 null mutant is defective in basal complex assembly and apicoplast division. PLoS ONE. 5:e12302. Eidell, K., Burke, T., and Gubbels, M.-J. 2010. Development of a screen to dissect Toxoplasma gondii egress. Molecular and Biochemical Parasitology 171(2): 97–10. Wilson, D.C., Grotenbreg, G.M., Liu, K.N., Zhao, Y., Frickel, E.-M., Gubbels, M.-J., Ploegh, H.L., and Yap, G.S. 2010. Differential regulation of effector- and central-memory responses to Toxoplasma gondii infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells. PLoS Pathogens 6(3): e1000815. Bushkin, G.G., Ratner, D.M., Cui, J., Banerjee, S., Duraisingh, M.T., Jennings, C.V., Dvorin, J.D., Gubbels, M.-J., Robertson, S.D., Steffen, M., O’Keefe, B.R., Robbins, P.W., and Samuelson, J. 2010. Evidence for Darwinian selection against asparagine-linked glycans of Plasmodium and Toxoplasma. Eukaryotic Cell 9: 228–241. Frickel, E.M., Sahoo, N., Hopp, J., Gubbels, M.-J., Craver, M.P., Knoll, L.J., Ploegh, H., and Grotebreg, G. 2008. Parasite stage-specific recognition of endogenous Toxoplasma gondii epitopes by CD8+T cells. The Journal of Infectious Diseases 198: 1625–1633.