个人简介

Dr. Xue is an Associate Professor of Medicine in the Division of Geriatric Medicine and Gerontology and a biostatistician and quantitative scientist focused on aging-related decline in muscle function and multisystem physiological determinants of late-life vulnerability. The breadth of Dr. Xue's impact on research on disability, frailty, systemic dysregulation and cognitive decline at the Johns Hopkins Medical Institutions is evidenced by his 86 peer reviewed publications since 2004 (47 publications over the last five years). Dr. Xue’s principal authorship of papers in the Archives of Internal Medicine, American Journal of Epidemiology, Journal of the American Geriatrics Society, and Journal of Gerontology: Medical Sciences during this span indicates his growing leadership role and national prominence in discovery on aging.

研究领域

Epidemiology of Aging, Frailty, Sarcopenia

My research interest focuses on the natural history of frailty and its phenotypic components including sarcopenia and low physical activity. As a co-investigator of the Women’s Health and Aging Studies since 2001, I’ve been spearheading the analysis of longitudinal data relating biomarkers of inflammation, hormonal dysregulation, and micronutrient deficiencies to the development and progression of frailty. This work is providing a critical foundation for the next generation of research to delineate the synergistic effects of dysregulation in multiple biological systems on frailty. It promises to provide new biological insights and, thereby, inform the development of new interventions to treat the concurrent multisystem changes that occur in accelerated aging. In addition, I have recently developed an interest in methods to study the clinical relevance of aging-related loss of muscle mass and strength in older adults (referred to as sarcopenia), with the goal of establishing the prognostic value of intra-person variability and change in muscle mass and strength for long-term health outcomes.

近期论文

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Xue QL, Varadhan R. What is missing in the validation of frailty instruments? J Am Med Dir Assoc. 2014 Feb;15(2):141-2. doi: 10.1016/j.jamda.2013.11.007. Epub 2014 Jan 7. PMID: 24405640 Xue QL, Bandeen-Roche K, Mielenz, TJ, Seplaki CL, Szanton SL, Thorpe RJ, Kalyani RR, Chaves PH, Dam TT, Ornstein K, RoyChoudhury A, Yao WL, Fried LP. Patterns of 12-Year Change in Physical Activity in Community-Dwelling Older Women: Can Modest Levels of Physical Activity Help Older Women Live Longer? Am J Epidemiol. 2012; DOI: 10.1093/aje/kws125. Szanton SL, Thorpe RJ, Boyd C, Tanner EK, Leff B, Agree E, Xue QL, Allen JK, Seplaki CL, Weiss C, Guralnik JM, Gitlin LN. Community aging in place, advancing better living for elders: a bio-behavioral-environmental intervention to improve function and health-related quality of life in disabled older adults. J Am Geriatr Soc. 2011 Dec;59(12):2314-20. PMID: 22091738 Yao X, Hamilton R, Weng N-P, Xue QL, Bream JH, Tian J, Yeh S-H, Resnick B, Xu XY, Walston JD, Fried LP, Leng SX. Frailty is associated with poor vaccine-induced antibody response and increased influenza infection in community-dwelling older adults. Vaccine. 2011 Jul 12;29(31):5015-21. PMID: 21565245 Xue QL, Walston JD, Fried LP, Beamer BA. Rate of decline in grip strength predicts the risk of falling, physical disability, and frailty: The Women's Health and Aging Study. Arch Intern Med. 2011 Jun;171(12): 1119:1121. PMID: 21709116 Xue QL. The Frailty Syndrome: Definition and Natural History. Clin in Geriatr Med. 2011 Feb;27(1):1-15. PMID: 21093718 Xue QL, Beamer BA, Chaves PHM, Guralnik JM, Fried LP. Heterogeneity in rate of decline in grip, hip, and knee strength and the risk of all-cause mortality: The Women's Health and Aging Study II. J Am Geriatr Soc. 2010 Nov;58(11):2076-84. PMID: 21054287 Tan EJ, Tanner EK, Seeman TE, Xue QL, Rebok GW, Frick KD, Carlson MC, Wang T, Piferi RL, McGill S, Whitfield KE, Fried LP. Marketing public health through older adult volunteering: Experience Corps as a social marketing intervention. Am J Public Health. 2010 Apr;100(4):727-34. PMID: 20167888 Rosenberg PB, Mielke MM, Xue QL, Carlson MC. Depressive Symptoms Predict Incident Cognitive Impairment in Cognitive Healthy Older Women. Am J Geriatr Psychiatry. 2010 Mar;18(3):204-11. PMID: 20224517 Boyd CM, Ricks M, Fried LP, Guralnik JM, Xue QL, Xia J, Bandeen-Roche K. Functional Decline and Recovery of Activities of Daily Living in Hospitalized, Disabled Older Women: The Women's Health and Aging Study I. J Am Geriatr Soc. 2009 Oct;57(10):1757-66. PMID: 19694869 Fried LP, Xue QL, Cappola A, Chaves PHM, Ferrucci L, Leng S, Semba RD, Varadhan R, Walston JD, Bandeen-Roche K. Multisystem physiologic abnormalities in frailty: evidence for nonlinear system biology at the macro level. J Gerontol A Biol Sci Med Sci. 2009 Oct;64(10):1049-57. PMID: 19567825 Deal JA, Carlson MC, Xue QL, Fried LP, Chaves PH. Anemia and 9-Year Domain-Specific Cognitive Decline in Community-Dwelling Older Women: The Women's Health and Aging Study II. J Am Geriatr Soc. 2009 Sep;57(9):1604-11. PMID: 19682133 Leng SX, Xue QL, Tian J, Huang Y, Yeh S-H, Fried LP. Associations of Neutrophil and Monocyte Counts with Frailty in Community-Dwelling Disabled Older Women: Results from the Women's Health and Aging Study I. Exp Gerontol. 2009 Aug; 44(8):511-6. PMID: 19457449 Stewart R, Xue QL, Masaki K, Petrovitch H, Ross GW, White LR, Launer LJ. Change in blood pressure and incident dementia: a 32-year prospective study. Hypertension. 2009 Aug; 54(2):233-40. PMID: 19564551 Thorpe RJ, Weiss CO, Xue QL, Fried LP. Transitions among disability levels or death in African American and white older women. J Gerontol A Biol Sci Med Sci. 2009 Jun; 64(6):670-4. PMID: 19228790 Blaum CS, Xue QL, Tian J, Semba RD, Fried LP, Walston JD. Is hyperglycemia associated with frailty status in older women? J Am Geriatr Soc. 2009 May; 57(5):840-7. PMID: 19484839 Cappola AR, Xue QL, Fried LP. Multiple Hormonal Deficiencies in Anabolic Hormones Are Found in Frail Older Women: The Women's Health and Aging Studies. J Gerontol A Biol Sci Med Sci. 2009 Feb; 64(2):243-8. PMID: 19182229 Carlson MC, Xue QL, Zhou J, Fried LP. Declines and deficits in executive function precede those in memory in high-functioning older women: The Women's Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2009 Jan; 64(1):110-7. PMID: 19182230 Varadhan R, Seplaki CS, Xue QL, Bandeen-Roche K., Fried LP. Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty. Mech Ageing Dev. 2008; 129(11):666-70. PMID: 18938195 Xue QL, Bandeen-Roche K, Zhou J, Varadhan R, Fried LP. Initial manifestations of frailty criteria and the development of frailty phenotype in the Women's Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2008; 63(9): 984–990. PMID: 18840805 Xue QL, Fried LP, Glass TA, Laffan AM, Chaves PHM. Life-Space Constriction, Development of Frailty, and the Competing Risk of Mortality: The Women's Health and Aging Study I. Am J Epidemiol. 2008; 167(2):240-48. PMID: 17906296 Leng SX, Xue QL, Tian J, Walston JD, Fried LP. Inflammation and frailty in older women. J Am Geriatr Soc. 2007; 55(6):864-71. PMID: 17537086 Tan EJ, Xue QL, Li T, Carlson MC, Fried LP. Volunteering: a physical activity intervention for older adults - The Experience Corps Program in Baltimore. J Urban Health. 2006; 83(5):954-69. PMID: 16763775 Lin SM, Xue QL, Simonsick EM, Tian J, Bandeen-Roche K, Fried LP, Bathon JM, Transitions to mobility difficulty associated with lower extremity osteoarthritis (oa) in high functioning older women: longitudinal data from the Women's Health and Aging Study II. Arthritis Rheum. 2006; 55(2):256-63. PMID: 16583416 Cappola AR, Xue QL, Walston JD, Leng SX, Ferrucci L, Guralnik J, Fried LP, DHEAS levels and mortality in disabled older women: The Women's Health and Aging Study I. J Gerontol A Biol Sci Med Sci. 2006;61(9):957-62. PMID: 16960027