Smith, Philip - Johns Hopkins University

个人简介

Dr. Philip Smith is a professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include pulmonary disease and critical care medicine. Dr. Smith earned his M.D. from the Tulane University School of Medicine. He completed his residency at Johns Hopkins Bayview Medical Center and performed a fellowship in pulmonary medicine at Johns Hopkins. His research interests include HIV and HAART effects on sleep and daytime function; sleep apnea and metabolic function; and obesity and neural control in sleep-disordered breathing. Dr. Smith was recognized by the Department of Medicine with a Levine Excellence in Mentoring Award in 2005.

研究领域

HIV and HAART effects on sleep and daytime function; Sleep apnea and metabolic function

近期论文

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McGinley BM, Kirkness JP, Schneider H, Lenka A, Smith PL, Schwartz AR. "Utilizing inspiratory airflows during standard polysomnography to assess pharyngeal function in children during sleep." Pediatr Pulmonol. 2015 Oct 16. doi: 10.1002/ppul.23329. [Epub ahead of print] Pho H, Hernandez AB, Arias RS, Leitner EB, Van Kooten S, Kirkness JP, Schneider H, Smith PL, Polotsky VY, Schwartz AR. "The effect of leptin replacement on sleep disordered breathing in the leptin-deficient ob/ob mouse." J Appl Physiol (1985). 2015 Oct 15:jap.00494.2015. doi: 10.1152/japplphysiol.00494.2015. [Epub ahead of print] Biselli P, Grossman PR, Kirkness JP, Patil SP, Smith PL, Schwartz AR, Schneider H. "The effect of increased lung volume in chronic obstructive pulmonary disease on upper airway obstruction during sleep." J Appl Physiol (1985). 2015 Aug 1;119(3):266-71. doi: 10.1152/japplphysiol.00455.2014. Epub 2015 Jun 5. Vuong C, Xie LH, Potter BM, Zhang J, Zhang P, Duan D, Nolan CK, Sciotti RJ, Zottig VE, Nanayakkara NP, Tekwani BL, Walker LA, Smith PL, Paris RM, Read LT, Li Q, Pybus BS, Sousa JC, Reichard GA, Smith B, Marcsisin SR. "Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics." Antimicrob Agents Chemother. 2015 Jul;59(7):3864-9. doi: 10.1128/AAC.00343-15. Epub 2015 Apr 13. Alinari L, Mahasenan KV, Yan F, Karkhanis V, Chung JH, Smith EM, Quinion C, Smith PL, Kim L, Patton JT, Lapalombella R, Yu B, Wu Y, Roy S, De Leo A, Pileri S, Agostinelli C, Ayers L, Bradner JE, Chen-Kiang S, Elemento O, Motiwala T, Majumder S, Byrd JC, Jacob S, Sif S, Li C, Baiocchi RA. "Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation." Blood. 2015 Apr 16;125(16):2530-43. doi: 10.1182/blood-2014-12-619783. Epub 2015 Mar 5. Brigham EP, Patil SP, Jacobson LP, Margolick JB, Godfrey R, Johnson J, Johnson-Hill LM, Reynolds S, Schwartz AR, Smith PL, Brown TT. Association between systemic inflammation and obstructive sleep apnea in men with or at risk for HIV infection. Antivir Ther. 2014 Feb 12. doi: 10.3851/IMP2745. [Epub ahead of print] PMID: 24518040 Schwartz AR, Smith PL, Oliven A. Electrical stimulation of the hypoglossal nerve: a potential therapy. J Appl Physiol (1985). 2014 Feb;116(3):337-44. doi: 10.1152/japplphysiol.00423.2013. Epub 2013 Jun 27. PMID: 23813525 Kezirian EJ, Goding GS Jr, Malhotra A, O'Donoghue FJ, Zammit G, Wheatley JR, Catcheside PG, Smith PL, Schwartz AR, Walsh JH, Maddison KJ, Claman DM, Huntley T, Park SY, Campbell MC, Palme CE, Iber C, Eastwood PR, Hillman DR, Barnes M. Hypoglossal nerve stimulation improves obstructive sleep apnea: 12-month outcomes. J Sleep Res. 2014 Feb;23(1):77-83. doi: 10.1111/jsr.12079. Epub 2013 Sep 4. PMID: 24033656 Yan F, Alinari L, Lustberg ME, Martin LK, Cordero-Nieves HM, Banasavadi-Siddegowda Y, Virk S, Barnholtz-Sloan J, Bell EH, Wojton J, Jacob NK, Chakravarti A, Nowicki MO, Wu X, Lapalombella R, Datta J, Yu B, Gordon K, Haseley A, Patton JT, Smith PL, Ryu J, Zhang X, Mo X, Marcucci G, Nuovo G, Kwon CH, Byrd JC, Chiocca EA, Li C, Sif S, Jacob S, Lawler S, Kaur B, Baiocchi RA. Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma. Cancer Res. 2014 Jan 22. [Epub ahead of print] PMID: 24453002 Ravis WR, Llanos-Cuentas A, Sosa N, Kreishman-Deitrick M, Kopydlowski KM, Nielsen C, Smith KS, Smith PL, Ransom JH, Lin YJ, Grogl M. Pharmacokinetics and absorption of paromomycin and gentamicin from topical creams used to treat cutaneous leishmaniasis. Antimicrob Agents Chemother. 2013 Oct;57(10):4809-15. doi: 10.1128/AAC.00628-13. Epub 2013 Jul 22. PMID: 23877689 Smith PL, Sewell DK. A competitive interaction theory of attentional selection and decision making in brief, multielement displays. Psychol Rev. 2013 Jul;120(3):589-627. doi: 10.1037/a0033140. Erratum in: Psychol Rev. 2013 Oct;120(4):902. PMID: 23915085 Wei T, Erlacher MA, Grossman P, Leitner EB, McGinley BM, Patil SP, Smith PL, Schneider H, Schwartz AR, Kirkness JP. Approach for streamlining measurement of complex physiological phenotypes of upper airway collapsibility. Comput Biol Med. 2013 Jun;43(5):600-6. doi: 10.1016/j.compbiomed.2012.12.006. Epub 2013 Mar 18. PMID: 23517555 Bird E, Smith PL, Seiffert D, Psaltis GC, Huang J, Schumacher WA. Does plexin-B1, a semaphorin 4D receptor, play a role in thrombosis? Thromb Res. 2013 Jun;131(6):564-5. doi: 10.1016/j.thromres.2013.03.018. Epub 2013 Apr 30. No abstract available. PMID: 23642655 Schwartz AR, Smith PL. Rebuttal from Alan R. Schwartz and Philip L. Smith. J Physiol. 2013 May 1;591(Pt 9):2235. doi: 10.1113/jphysiol.2013.252528. No abstract available. PMID: 23740881 Schwartz AR, Smith PL. CrossTalk proposal: the human upper airway does behave like a Starling resistor during sleep. J Physiol. 2013 May 1;591(Pt 9):2229-32. doi: 10.1113/jphysiol.2012.250654. No abstract available. PMID: 23740879