个人简介

Dr. Rupak Shivakoti is an Instructor of Medicine (Infectious Diseases) at the Johns Hopkins University School of Medicine. He also serves on the faculty of the Johns Hopkins Center for Clinical Global Health Education (CCGHE). Dr. Shivakoti’s research focuses primarily on epidemiological studies that examine the role of inflammation, nutrition and microbiome in HIV and TB. These studies are conducted in adult and maternal-infant populations, both in the US and internationally (with a focus in India). After completing his undergraduate degree in biology from DePauw University, Dr. Shivakoti received an MSPH in International Health and a PhD in Molecular Microbiology and Immunology from the Johns Hopkins Bloomberg School of Public Health. His PhD thesis, under the direction of Dr. Diane Griffin, focused on the innate and aptive immune responses to measles virus and measles vaccine. He completed his post-doctoral training in the Infectious Disease Division at JHU with Dr. Amita Gupta serving as his mentor. B.A., DePauw University (Indiana) (2007) M.S.P.H., Johns Hopkins University (Maryland) (2013) Ph.D., Johns Hopkins University (Maryland) (2013)

研究领域

Infectious diseases; Epidemiology; Nutrition; Inflammation; Human Immunodeficiency Virus (HIV); Tuberculosis; Micronutrient deficiencies; Gut microbiome

Dr. Shivakoti’s research focuses primarily on epidemiological studies that assess the role of immunology and nutrition within the context of HIV and tuberculosis. Since 2013, he has studied how micronutrient deficiencies and inflammation affect HIV treatment outcomes in adults from resource-limited countries. In other studies, he is evaluating risk factors for infant outcomes among HIV-infected and uninfected maternal-infant populations from Pune, India. He was awarded a 2016 Pathway to Independence Award (K99/R00 grant) to serve as the principal investigator of a study of HIV-infected and uninfected pregnant women from India. The study aims to determine the association of maternal inflammation, diet and gut microbiome during pregnancy with adverse birth outcomes, including preterm birth. Dr. Shivakoti is also principal investigator of two Johns Hopkins Center for AIDS Research (CFAR) grants, including one examining the temporal dynamics of the gut microbiome during pregnancy among HIV-infected and uninfected women.

近期论文

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Shivakoti R, Gupte N, Yang W, Mwelase N, Kanyama C, Tang A, Pillay S, Samaneka W, Riviere C, Berendes S, Lama JR, Cardoso SW, Sugandhavesa P, Semba RD, Christian P, Campbell TB, Gupta A for the NWCS 319 and PEARLS Study Team. Pre-antiretroviral therapy serum selenium concentrations predict WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy. Nutrients. 2014;6(11):5061-78 Shivakoti R, Gupte N, Yang W, Mwelase N, Kanyama C, Pillay S, Samaneka W, Riviere C, Berendes S, LaRosa A, Cardoso SW, Sugandhavesa P, Bollinger RC, Currier JS, Tang AM, Semba RD, Christian P, Campbell TB, Gupta A for the NWCS 319 and PEARLS Study Team. Concurrent anemia and elevated CRP predicts HIV clinical treatment failure post-antiretroviral therapy initiation. Clinical Infectious Diseases. 2015;61(1):102-10 Shivakoti R, Christian P, Yang W, Gupte N, Mwelase N, Kanyama C, Pillay S, Samaneka W, Santos B, Poongulali S, Tripathy S, Riviere C, Berendes S, Lama JR, Cardoso SW, Sugandhavesa P, Tang AM, Semba RD, Campbell TB, Gupta A for the NWCS 319 and PEARLS Study Team. Prevalence and risk factors of micronutrient deficiencies pre- and post-antiretroviral therapy (ART) among a diverse multicountry cohort of HIV-infected adults. Clinical Nutrition. 2016;35(1):183-9 Shivakoti R, Gupta A, Ray J, Gupte N, Bhosale R, Uprety P, Patil S, Balasubramanian U, Mave V, Kinikar A, Bharadwaj R, Bollinger RC and Persaud D. Soluble CD14: an independent biomarker for risk to mother-to-child HIV-transmission in setting of pre- and post-exposure to antiretrovirals prophylaxis. Journal of Infectious Diseases. 2016;213(5):762-5 Shivakoti R, Yang WT, Berendes S, Mwelase N, Kanyama C, Pillay S, Samaneka W, Santos B, Poongulali S, Tripathy S, Riviere C, Lama JR, Cardoso SW, Sugandhavesa P, Balagopal A, Gupte N, Semba RD, Campbell TB, Bollinger RC, Gupta A for the NWCS 319 and PEARLS Study Team. Persistently Elevated CRP in first year of ART despite virologic suppression is associated with HIV disease progression in resource limited settings. Journal of Infectious Diseases. 2016;213(7):1074-8